Protein Alignment PPP3CA and flw

DIOPT Version :10

• Sequence 1: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_727418.1
• Gene: flw / 44289
• FlyBaseID: FBgn0000711
• Length: 461
• Species: Drosophila melanogaster
• Alignment Length: 334
• Identity: 120/334 - (35%)
• Similarity: 184/334 - (55%)
• Gaps: 42/334 - (12%)

Human    24 PPSHRLTAKEVFDND----GKPRVDILKAHLM----------------KEGRLEESVALRIITEG 68
            |||..:.:.   |.|    ..||.:..|:.|.                |:.::.|:....:..:.
  Fly   111 PPSETMISA---DGDQITVHHPREEPKKSRLKLRDFFVAEFVRSCRTGKQVQMTEAEVRGLCLKS 172

Human    69 ASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL 133
            ..|..|:..||:::||:.:|||||||:.||::|||.||.|....|||||||||||..|:|.:..|
  Fly   173 REIFLQQPILLELEAPLIICGDIHGQYTDLLRLFEYGGFPPAANYLFLGDYVDRGKQSLETICLL 237

Human   134 WALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCV 198
            .|.||.||:..|||||||||..:...:.|..|||.:|:.:::....|.|:|||:||:::::..|.
  Fly   238 LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKIFCC 302

Human   199 HGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYP 263
            ||||||::..::.||:|.|..:.|..|.:||:|||||      :|..:.:..|. ||.|:.:...
  Fly   303 HGGLSPDLQGMEQIRRLMRPTDVPDTGLLCDLLWSDP------DKDVQGWGEND-RGVSFTFGVD 360

Human   264 AVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNV 328
            .|.:||..:.|..|.|||:..:.||..:.:.|      |:|:||||||...::|...::..::.:
  Fly   361 VVSKFLNRHELDLICRAHQVVEDGYEFFARRQ------LVTLFSAPNYCGEFDNAGGMMTVDDTL 419

Human   329 MNIRQFNCS 337
            |      ||
  Fly   420 M------CS 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	115/313 (37%)
		Catalytic. /evidence=ECO:0000305	56..340		110/282 (39%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336		1/8 (13%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521
flw	NP_727418.1	MPP_PP1_PPKL	149..428	CDD:277359	111/293 (38%)