Protein Alignment PPP3CA and CanA1

DIOPT Version :10

• Sequence 1: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_524600.3
• Gene: CanA1 / 43670
• FlyBaseID: FBgn0010015
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 374/538 - (69%)
• Similarity: 436/538 - (81%)
• Gaps: 42/538 - (7%)

Human    13 TTDRVVKAVPFPPSHRLTAKEVFDN--DGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQE 75
            |.:|:|..||.||:|:||..||:|:  .|||..|.|:.|.:.|||:||:||||||||||::||:|
  Fly    51 TRERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREE 115

Human    76 KNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILY 140
            ||::|::||:|||||||||||||:|||||||.||.||||||||||||||||||||||||:|||.|
  Fly   116 KNMIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITY 180

Human   141 PKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPE 205
            |.||.|||||||||||||||||||||.|||||.:|||||:||||||||||:||||||:|||||||
  Fly   181 PTTLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPE 245

Human   206 INTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQ 270
            |.|||||:.|:||:||||||||||:||||||||||||||.|.|:||:|||||||:||.|.|||||
  Fly   246 IFTLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQ 310

Human   271 HNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 335
            .||||||:|||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
  Fly   311 KNNLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFN 375

Human   336 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--GSEED---------------- 382
            ||||||||||||||||||||||||||||||||:|||||||||  |.:::
  Fly   376 CSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANA 440

Human   383 ----------GFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVL 437
                      ....:.:|.|||:|||||||||||:||||:|||||||||.||||||||.||.|.|
  Fly   441 SNNNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGAL 505

Human   438 SGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAM--PSDANLNSIN 500
            |||:.:|:          ||::|.:....|.||.||||||.:||||||||..:  .|.:::.::.
  Fly   506 SGGRDSLK----------EALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVT 560

Human   501 KALTSETNGTDSNGSNSS 518
            ::.:|.:|..::|.:.||
  Fly   561 RSSSSSSNNNNNNSNTSS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	255/303 (84%)
		Catalytic. /evidence=ECO:0000305	56..340		243/283 (86%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414		4/6 (67%)
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521		17/46 (37%)
CanA1	NP_524600.3	MPP_PP2B	81..385	CDD:277361	255/303 (84%)