DRSC/TRiP Functional Genomics Resources

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Protein Alignment PPP3CA and Pp1alpha-96A

DIOPT Version :10

Sequence 1:NP_000935.1 Gene:PPP3CA / 5530 HGNCID:9314 Length:521 Species:Homo sapiens
Sequence 2:NP_524484.1 Gene:Pp1alpha-96A / 42922 FlyBaseID:FBgn0003134 Length:327 Species:Drosophila melanogaster


Alignment Length:306 Identity:115/306 - (37%)
Similarity:176/306 - (57%) Gaps:33/306 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    52 KEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFL 116
            |..:|.||....:..:...|...:..||:::||:.:|||||||::||::|||.||.|..:.||||
  Fly    24 KNVQLSESEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFL 88

Human   117 GDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDA 181
            |||||||..|:|.:..|.|.||.|.:..|||||||||..:...:.|..|||.:|:.:::....|.
  Fly    89 GDYVDRGKQSLETICLLLAYKIKYAENFFLLRGNHECASINRIYGFYDECKRRYTIKLWKTFTDC 153

Human   182 FDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLED---FGNEK 243
            |:|||:||:::::..|.||||||::::::.||::.|..:.|..|.:||:|||||.:|   :|...
  Fly   154 FNCLPVAAIVDEKIFCCHGGLSPDLSSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTMGWGEND 218

Human   244 TQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSA 308
                      ||.|:.:....|.:|||.:....|.|||:..:.||..:.|.|      |:|:|||
  Fly   219 ----------RGVSFTFGAEVVGKFLQKHEFDLICRAHQVVEDGYEFFAKRQ------LVTLFSA 267

Human   309 PNYLDVYNNKAAVLKYENNVMNIRQFNCS--------PHPYWLPNF 346
            |||...::|..|::..::.:|      ||        ...:..|||
  Fly   268 PNYCGEFDNAGAMMSVDDTLM------CSFQILKPADKRRFVYPNF 307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PPP3CANP_000935.1 MPP_PP2B 41..345 CDD:277361 112/303 (37%)
Catalytic. /evidence=ECO:0000305 56..340 111/294 (38%)
SAPNY motif. /evidence=ECO:0000305|PubMed:26248042 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042 327..336 1/8 (13%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402 341..369 3/6 (50%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34 392..406
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 407..414
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402 465..487
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521
Pp1alpha-96ANP_524484.1 MPP_PP1_PPKL 6..296 CDD:277359 112/293 (38%)
Blue background indicates that the domain is not in the aligned region.

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