Protein Alignment PPP3CA and Ppp3ca

DIOPT Version :10

• Sequence 1: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Sequence 2: XP_063137376.1
• Gene: Ppp3ca / 24674
• RGDID: 3382
• Length: 585
• Species: Rattus norvegicus
• Alignment Length: 585
• Identity: 518/585 - (88%)
• Similarity: 520/585 - (88%)
• Gaps: 64/585 - (10%)

Human     1 MSEPKAIDPKLSTTDRVVK---------------------------------------------- 19
            |||||||||||||||||||
  Rat     1 MSEPKAIDPKLSTTDRVVKGKRSAAAARGAPSAAGDRPPLPRPGCPSPASAGDLLGSPARGDPLL 65

Human    20 ------------------AVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIIT 66
                              :||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 RRALPPHRPPGPNGGFYLSVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIIT 130

Human    67 EGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVL 131
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 EGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVL 195

Human   132 YLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFL 196
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 YLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFL 260

Human   197 CVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYS 261
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 CVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYS 325

Human   262 YPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYEN 326
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 YPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYEN 390

Human   327 NVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAA 391
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 NVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAA 455

Human   392 RKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADE 456
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 RKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADE 520

Human   457 AIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ 521
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
  Rat   521 AIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ 585

Human   522  521
              Rat   586  585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	302/303 (100%)
		Catalytic. /evidence=ECO:0000305	56..340		282/283 (100%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406		13/13 (100%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414		6/6 (100%)
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487		21/21 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521		44/45 (98%)
Ppp3ca	XP_063137376.1	None