Protein Alignment PPP3CA and Ppp3ca

DIOPT Version :10

• Sequence 1: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_032939.1
• Gene: Ppp3ca / 19055
• MGIID: 107164
• Length: 521
• Species: Mus musculus
• Alignment Length: 521
• Identity: 519/521 - (99%)
• Similarity: 520/521 - (99%)
• Gaps: 0/521 - (0%)

Human     1 MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRII 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRII 65

Human    66 TEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 TEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECV 130

Human   131 LYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQF 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 LYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQF 195

Human   196 LCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFY 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 LCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFY 260

Human   261 SYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYE 325
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 SYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYE 325

Human   326 NNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAA 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 NNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAA 390

Human   391 ARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEAD 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 ARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEAD 455

Human   456 EAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNI 520
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Mouse   456 EAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNI 520

Human   521 Q 521
            |
Mouse   521 Q 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	302/303 (100%)
		Catalytic. /evidence=ECO:0000305	56..340		282/283 (100%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406		13/13 (100%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414		6/6 (100%)
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487		21/21 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521		44/45 (98%)
Ppp3ca	NP_032939.1	MPP_PP2B	41..345	CDD:277361	302/303 (100%)
		Catalytic. /evidence=ECO:0000305	56..340		282/283 (100%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209	327..336		8/8 (100%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871	341..369		27/27 (100%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871	392..406		13/13 (100%)
		Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871	407..414		6/6 (100%)
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871	465..487		21/21 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521		44/45 (98%)