Protein Alignment FBXW7 and fbxw7

DIOPT Version :10

• Sequence 1: NP_361014.1
• Gene: FBXW7 / 55294
• HGNCID: 16712
• Length: 707
• Species: Homo sapiens
• Sequence 2: XP_021329580.1
• Gene: fbxw7 / 564991
• ZFINID: ZDB-GENE-090313-79
• Length: 835
• Species: Danio rerio
• Alignment Length: 783
• Identity: 576/783 - (73%)
• Similarity: 613/783 - (78%)
• Gaps: 98/783 - (12%)

Human     1 MNQELLSVGS-------KRRRTGGSLRGNPSSS---QVDEEQMNRVVEEEQQQQLRQQEEEHTAR 55
            |||:|||.||       :|.|.|.:..||..|.   |...|..::|:||.:|::.:||..|....
Zfish    75 MNQDLLSGGSGSRAAQQQRPRPGTAGAGNSISGRTPQPQPEHPDQVLEEPEQEEAQQQRREPAEE 139

Human    56 NGEVVGVEPRPGGQNDSQQGQ----------LEENNNRFISVDEDSSGNQ--------------- 95
            ..|        ||....|.|.          :|:...|...|:.|..|.|
Zfish   140 EDE--------GGPERQQDGDEQPWPSGGEPMEDGEGRRSEVNGDEKGAQWLWEQEQRRRRRPHR 196

Human    96 ---EEQEEDEEH----------AGEQDEEDEE--------EEEMDQESDDFDQSDDSSREDEH-- 137
               ||.||:||:          ||.:.|||::        ||||||:||:|:.|::|.||:|.
Zfish   197 EEEEENEEEEENNNSGREGQVGAGLRSEEDDDRPEEDNEGEEEMDQDSDEFEHSEESEREEEEED 261

Human   138 ---------THTNSVTNSSSIVDLPVHQ--------LSSPFYTKTTKMKRKLDHGSEVRSFSLGK 185
                     .|:.|:..|.|..:....|        |.||     .:||||||||.|||||:.||
Zfish   262 GEEEEGEEGLHSPSLRTSVSDHNDNTDQSSGRQRQSLRSP-----NRMKRKLDHGPEVRSFTTGK 321

Human   186 KPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKL 250
            |||     .|.||    ...|.|||||||.|||..|||||||:||||||||||:.||||||||||
Zfish   322 KPC-----PSPTG----QQYPATFGDLRAVNGQVPQRRRITSIQPPTGLQEWLRTFQSWSGPEKL 377

Human   251 LALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILA 315
            |||||||||||||||||||||||||||||||||||:||||:||||||||||||||||||||||||
Zfish   378 LALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPRELALHVLSFLEPKDLLQAAQTCRYWRILA 442

Human   316 EDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPK-VLKGH 379
            ||||||:||||||||||||||||||||||||.|||||||||||||||||||||:||||| |||||
Zfish   443 EDNLLWKEKCKEEGIDEPLHIKRRKVIKPGFTHSPWKSAYIRQHRIDTNWRRGDLKSPKVVLKGH 507

Human   380 DDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLK 444
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   508 DDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLK 572

Human   445 VWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 509
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   573 VWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 637

Human   510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   638 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 702

Human   575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVIT 639
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Zfish   703 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPHKHQSAVTCLQFNKNFVIT 767

Human   640 SSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDV 704
            ||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   768 SSDDGTVKLWDLRTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDV 832

Human   705 DMK 707
            |||
Zfish   833 DMK 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW7	NP_361014.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..151		63/216 (29%)
		F-box_FBXW7	264..322	CDD:438905	55/57 (96%)
		WD40	311..692	CDD:441893	375/381 (98%)
		WD 1	378..418		39/39 (100%)
		WD40 repeat	384..419	CDD:293791	34/34 (100%)
		WD 2	420..456		35/35 (100%)
		WD40 repeat	425..459	CDD:293791	33/33 (100%)
		WD 3	459..498		38/38 (100%)
		WD40 repeat	464..498	CDD:293791	33/33 (100%)
		WD 4	500..536		35/35 (100%)
		WD40 repeat	505..538	CDD:293791	32/32 (100%)
		WD 5	539..578		38/38 (100%)
		WD40 repeat	544..578	CDD:293791	33/33 (100%)
		WD 6	580..618		37/37 (100%)
		WD40 repeat	586..618	CDD:293791	31/31 (100%)
		WD 7	622..659		35/36 (97%)
		WD40 repeat	627..649	CDD:293791	21/21 (100%)
fbxw7	XP_021329580.1	F-box_FBXW7	391..449	CDD:438905	55/57 (96%)
		WD40	503..778	CDD:238121	273/274 (100%)
		WD40 repeat	512..547	CDD:293791	34/34 (100%)
		WD40 repeat	553..587	CDD:293791	33/33 (100%)
		WD40 repeat	592..626	CDD:293791	33/33 (100%)
		WD40 repeat	633..666	CDD:293791	32/32 (100%)
		WD40 repeat	672..706	CDD:293791	33/33 (100%)
		WD40 repeat	714..746	CDD:293791	31/31 (100%)
		WD40 repeat	755..777	CDD:293791	21/21 (100%)