Protein Alignment FBXW7 and sel-10

DIOPT Version :10

• Sequence 1: NP_361014.1
• Gene: FBXW7 / 55294
• HGNCID: 16712
• Length: 707
• Species: Homo sapiens
• Sequence 2: NP_506421.1
• Gene: sel-10 / 179878
• WormBaseID: WBGene00004767
• Length: 587
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 269/638 - (42%)
• Similarity: 366/638 - (57%)
• Gaps: 106/638 - (16%)

Human   106 GEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKR 170
            |....||:|    ....:|.:.:|:.   :|.:::|..::|.:     ..:|||     :..::.
 Worm    12 GSMTPEDQE----PVTDNDMEYNDNG---EESSYSNGSSSSYN-----ADKLSS-----SRPLQH 59

Human   171 KLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQ 235
            |||                            .||:|:...||...                  ::
 Worm    60 KLD----------------------------LSASPSRNNDLNPR------------------VE 78

Human   236 EWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 300
            ..:.:|:..|..|::.|...|:.....|.::.:..:|||.|||||:|.||.||.:.:|..|...|
 Worm    79 HLIALFKDLSSAEQMDAFTRLLQESNMTNIRQLRAIIEPHFQRDFLSCLPVELGMKILHNLTGYD 143

Human   301 LLQAAQTCRYWRILAEDNLLWREKCKEE----------------------GIDEPLHI------- 336
            ||:.||..:.|::::|.:.:|:....||                      |:..|.||
 Worm   144 LLKVAQVSKNWKLISEIDKIWKSLGVEEFKHHPDPTDRVTGAWQGTAIAAGVTIPDHIQPCDLNV 208

Human   337 -KRRKVIKPG--FIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGS 398
             :..|:.|.|  |..:..||.|:|..:|:.||....:....||:||:||||||:|...:.:|:||
 Worm   209 HRFLKLQKFGDIFERAADKSRYLRADKIEKNWNANPIMGSAVLRGHEDHVITCMQIHDDVLVTGS 273

Human   399 DDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NIIISGSTDRTLKVWNAETGECIHTLYGHT 461
            ||||||||....|:.:.||||||||||:||:..  ..|:|||||||:|||:...|..:|||.|||
 Worm   274 DDNTLKVWCIDKGEVMYTLVGHTGGVWTSQISQCGRYIVSGSTDRTVKVWSTVDGSLLHTLQGHT 338

Human   462 STVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 526
            ||||||.:....:|:||||.||||||:|:|:.|..|.||.|||||||:||..||||.|||.||:|
 Worm   339 STVRCMAMAGSILVTGSRDTTLRVWDVESGRHLATLHGHHAAVRCVQFDGTTVVSGGYDFTVKIW 403

Human   527 DPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDV---ETGNCIHTLTGHQSLTSG 586
            :..|..|:.||.||.||||||.|:...  |.||||||||||||.   |...|:..|.||.|||||
 Worm   404 NAHTGRCIRTLTGHNNRVYSLLFESERSIVCSGSLDTSIRVWDFTRPEGQECVALLQGHTSLTSG 468

Human   587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWD 650
            |:|:.|||||.||||.|::|||..|.|:..|.|   |:||:|.|| |.:|.|.||||||||||||
 Worm   469 MQLRGNILVSCNADSHVRVWDIHEGTCVHMLSG---HRSAITSLQWFGRNMVATSSDDGTVKLWD 530

Human   651 LKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFD 703
            ::.|..||:||||:|||:||.:||:.:::|.|.|||||||.|||||:::||||
 Worm   531 IERGALIRDLVTLDSGGNGGCIWRLCSTSTMLACAVGSRNNTEETKVILLDFD 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW7	NP_361014.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..151		9/44 (20%)
		F-box_FBXW7	264..322	CDD:438905	22/57 (39%)
		WD40	311..692	CDD:441893	214/420 (51%)
		WD 1	378..418		22/39 (56%)
		WD40 repeat	384..419	CDD:293791	18/34 (53%)
		WD 2	420..456		20/37 (54%)
		WD40 repeat	425..459	CDD:293791	18/35 (51%)
		WD 3	459..498		23/38 (61%)
		WD40 repeat	464..498	CDD:293791	18/33 (55%)
		WD 4	500..536		22/35 (63%)
		WD40 repeat	505..538	CDD:293791	19/32 (59%)
		WD 5	539..578		24/43 (56%)
		WD40 repeat	544..578	CDD:293791	20/38 (53%)
		WD 6	580..618		23/37 (62%)
		WD40 repeat	586..618	CDD:293791	18/31 (58%)
		WD 7	622..659		23/37 (62%)
		WD40 repeat	627..649	CDD:293791	15/22 (68%)
sel-10	NP_506421.1	F-box_SF	107..165	CDD:459239	22/57 (39%)
		WD40	248..530	CDD:238121	169/284 (60%)
		WD40 repeat	259..294	CDD:293791	18/34 (53%)
		WD40 repeat	300..336	CDD:293791	18/35 (51%)
		WD40 repeat	341..375	CDD:293791	18/33 (55%)
		WD40 repeat	382..415	CDD:293791	19/32 (59%)
		WD40 repeat	421..460	CDD:293791	20/38 (53%)
		WD40 repeat	468..500	CDD:293791	18/31 (58%)
		WD40	495..>572	CDD:475233	47/79 (59%)
		WD40 repeat	506..529	CDD:293791	15/22 (68%)