Protein Alignment RHOT1 and Miro

DIOPT Version :10

• Sequence 1: XP_047292309.1
• Gene: RHOT1 / 55288
• HGNCID: 21168
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_651205.2
• Gene: Miro / 42845
• FlyBaseID: FBgn0039140
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 704
• Identity: 324/704 - (46%)
• Similarity: 448/704 - (63%)
• Gaps: 87/704 - (12%)

Human    44 ARVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANV 108
            |.|||||||:||||||:|||||||||||||||:||||:|||.|||:|..|||::.|..||::|:|
  Fly    20 AGVGKTSLILSLVSEEYPEEVPPRAEEITIPANVTPEQVPTSIVDFSAVEQSEDALAAEINKAHV 84

Human   109 ICIVYAVNNKHSIDKVTSRWIPLINER------------------TDKDS-RLPLILVGNKSDLV 154
            :||||||::..::|::||.|:||:..:                  |.::. |.|::|||||.||:
  Fly    85 VCIVYAVDDDDTLDRITSHWLPLVRAKCNPSLDGEGDAEAEAEGDTQREPIRKPIVLVGNKIDLI 149

Human   155 EYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKA 219
            |||:|:::|.||..|.|||:|||||||:|.||||:||||||||||||.|||..||:|:..||.|:
  Fly   150 EYSTMDSVLAIMEDYPEIESCVECSAKSLHNISEMFYYAQKAVLHPTSPLYMMEEQELTSACKKS 214

Human   220 LTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLF 284
            |.|||||.|.|.|..|||.|||.|||.||||||.||.|::||.|::|::.||:.:..:|||||||
  Fly   215 LVRIFKICDIDGDNLLNDYELNLFQRRCFNTPLQPQILDEVKAVIQKNVPDGIYNDAVTLKGFLF 279

Human   285 LHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDL 349
            ||.|||||||:||||.|||||||:|.|::..|||.|.|||||..:|||:|....||.:.|:::|.
  Fly   280 LHCLFIQRGRNETTWAVLRRFGYNDQLEMCQEYLRPPLKIPPGSSTELSHRGQQFLIAVFERYDR 344

Human   350 DRDCALSPDELKDLFKVFPYIPW--GPDVNNTVCTNE-RGWITYQGFLSQWTLTTYLDVQRCLEY 411
            |.|.||||:|.|.||...|..||  ..|:..:...|| .||:|..|:|.:|||.|.:||.:.:||
  Fly   345 DGDGALSPEEHKMLFSTCPAAPWSYSTDIRKSCPINETTGWVTLHGWLCRWTLMTLIDVVKTMEY 409

Human   412 LGYLGYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVLQALLGRNLMR 476
            |.|||::: .|.:||.:|:.|||:::|||.|:|:.|:|::|:|||.|..||:|:.:..|..::
  Fly   410 LAYLGFNV-HENDSQLAAIHVTRERRIDLAKRQSSRSVYKCHVIGPKGSGKTGMCRGFLVEDM-- 471

Human   477 QKKIREDHKS--YYAINTVYVYGQEKYLLLHDIS---ESEFLTEAEIICDVVCLVYDVSNPKSFE 536
            .|.|.::.|:  ...||:|.||||||:|:|.||.   ..:.|...|:.|||.|||||.|||:|||
  Fly   472 HKLIGKEFKTNVVNCINSVQVYGQEKHLILRDIDVRHALDPLQPQEVNCDVACLVYDSSNPRSFE 536

Human   537 YCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIF 601
            |.|||:.:::.:|:||.:||..|.|:.|.:|:|.:.|::||.|:|:.||..|:..|   ..|:::
  Fly   537 YVARIYIKYYAESKIPVMIVGTKCDMDERRQDYLMQPSEFCDKYKLLPPHLFSLKT---NKKELY 598

Human   602 VKLTTMAMYPEDHYRDRLSRDMGHTDRIENLRKIWVFLKTAFHARLRCMCTCNRCTFCICQNFLN 666
            .||.|||.:|                   ..:..|:..
  Fly   599 TKLATMAAFP-------------------RFQAAWILF--------------------------- 617

Human   667 SDLLQSVKNKIFTAVLNRHVTQADL--KSSTFWLRASFGATVFAVLGFAMYKAL 718
                  .|:::.....:.|:.|..|  :....||:|..|.....:|||.:.|.:
  Fly   618 ------YKHRLVQLWESAHLRQFGLMTEDPKLWLKAGLGVAAATMLGFIVLKTI 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT1	XP_047292309.1	Miro1	46..200	CDD:206680	101/172 (59%)
		EF_assoc_2	250..334	CDD:462444	53/83 (64%)
		EF_assoc_1	372..441	CDD:462443	30/71 (42%)
		Miro2	446..611	CDD:206679	72/169 (43%)
Miro	NP_651205.2	Miro1	10..195	CDD:206680	102/174 (59%)
		EF_assoc_2	245..329	CDD:462444	53/83 (64%)
		FRQ1	<333..>360	CDD:444056	13/26 (50%)
		EF_assoc_1	367..437	CDD:462443	29/70 (41%)
		Miro2	444..620	CDD:206679	74/232 (32%)