Protein Alignment RHOT1 and rhot1a

DIOPT Version :10

• Sequence 1: XP_047292309.1
• Gene: RHOT1 / 55288
• HGNCID: 21168
• Length: 722
• Species: Homo sapiens
• Sequence 2: XP_009297700.1
• Gene: rhot1a / 327143
• ZFINID: ZDB-GENE-030131-5354
• Length: 709
• Species: Danio rerio
• Alignment Length: 728
• Identity: 549/728 - (75%)
• Similarity: 609/728 - (83%)
• Gaps: 82/728 - (11%)

Human    45 RVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVI 109
            :||||||||||||||||:|||||||||||||||||||||||||||||||||||||:|||::||||
Zfish    14 KVGKTSLIMSLVSEEFPDEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLYQEITKANVI 78

Human   110 CIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIET 174
            ||||:||||.||:||||.||||||||||||||:|||||||||||||:|||||||||||||:||||
Zfish    79 CIVYSVNNKKSIEKVTSHWIPLINERTDKDSRVPLILVGNKSDLVEHSSMETILPIMNQYSEIET 143

Human   175 CVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAE 239
            |||||||||||||||||||||||||||||||.||||||||:|||||||||||||.||||.|||.|
Zfish   144 CVECSAKNLKNISELFYYAQKAVLHPTGPLYSPEEKEMKPSCIKALTRIFKISDLDNDGILNDNE 208

Human   240 LNFFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTWTVLRR 304
            ||||||.|||.||||||||||||||||:::|||.|:|||||||||||||||||||||||||||||
Zfish   209 LNFFQRTCFNIPLAPQALEDVKNVVRKNMTDGVKDNGLTLKGFLFLHTLFIQRGRHETTWTVLRR 273

Human   305 FGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKVFPY 369
            |||||||:||.||||||.||||||||||||:|||||||.|||||.||||||||||||||||||||
Zfish   274 FGYDDDLELTQEYLFPLFKIPPDCTTELNHNAYLFLQSVFDKHDKDRDCALSPDELKDLFKVFPY 338

Human   370 IPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAVTVTR 434
            :||||||||||||||:|||||||:||||||||||||||||||||||||||:.||||||:|:||||
Zfish   339 MPWGPDVNNTVCTNEQGWITYQGYLSQWTLTTYLDVQRCLEYLGYLGYSIIQEQESQAAAITVTR 403

Human   435 DKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYGQE 499
            :|:||||||||||:||||||:|.:.|||||.|||.|||||:|||:|||||||||||:|.||||||
Zfish   404 NKRIDLQKKQTQRSVFRCNVLGARGCGKSGFLQAFLGRNLVRQKRIREDHKSYYAISTTYVYGQE 468

Human   500 KYLLLHDI-SESEFLTEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLH 563
            ||||||:: .:.|||:||::.|||||||||:|||:||||||:::|:|||||:.||:|:|||||||
Zfish   469 KYLLLHEVLPDVEFLSEADLACDVVCLVYDISNPRSFEYCAKVYKKHFMDSKTPCVIIAAKSDLH 533

Human   564 EVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPEDHYRDRLSRDMGHTDR 628
            |.:|.||:||.|||||||:.|||.|||||.:|||||::.|||||||||
Zfish   534 EARQYYSLSPLDFCRKHKLHPPQLFTCNTTEAPSKDLYTKLTTMAMYP----------------- 581

Human   629 IENLRKIWVFLKTAFHARLRCMCTCNRCTFCICQNFLNSDLLQSVKNKIFTAVL----------- 682
                           ||:|||||.|||||:|||.|.|||:|::|||.|..:|||
Zfish   582 ---------------HAKLRCMCGCNRCTYCICHNLLNSELVRSVKAKFSSAVLNRLRPFIQDLG 631

Human   683 --------------------------------------NRHVTQADLKSSTFWLRASFGATVFAV 709
                                                  |||:||||||:||||||||.|||||||
Zfish   632 TFLLADEESSLTHQVHAVSFVEDSVFMESSVDPFVPACNRHMTQADLKNSTFWLRASVGATVFAV 696

Human   710 LGFAMYKALLKQR 722
            |||||||||||||
Zfish   697 LGFAMYKALLKQR 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT1	XP_047292309.1	Miro1	46..200	CDD:206680	142/153 (93%)
		EF_assoc_2	250..334	CDD:462444	74/83 (89%)
		EF_assoc_1	372..441	CDD:462443	60/68 (88%)
		Miro2	446..611	CDD:206679	121/165 (73%)
rhot1a	XP_009297700.1	Miro1	3..169	CDD:206680	142/154 (92%)
		EF_assoc_2	220..303	CDD:462444	74/82 (90%)
		EF-hand_6	308..336	CDD:463869	25/27 (93%)
		EF_assoc_1	341..410	CDD:462443	60/68 (88%)
		Miro2	415..582	CDD:206679	123/198 (62%)