Protein Alignment RHOT1 and gem1

DIOPT Version :10

• Sequence 1: XP_047292309.1
• Gene: RHOT1 / 55288
• HGNCID: 21168
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_587725.1
• Gene: gem1 / 2538910
• PomBaseID: SPCC320.04C
• Length: 630
• Species: Schizosaccharomyces pombe
• Alignment Length: 582
• Identity: 199/582 - (34%)
• Similarity: 319/582 - (54%)
• Gaps: 31/582 - (5%)

Human    46 VGKTSLIMSLVSEEFPEEVPPRAEEITIPADV-TPERVPTHIVDYSEAEQSDEQLHQEISQANVI 109
            |||:|||.:|:.|:....:|.....|:||::. :.:.|...:||........|.|..||.:||||
pombe    14 VGKSSLISALIQEDNVTSIPKVFPIISIPSNPDSNDDVSLVLVDTQSDSNEREYLAAEIKKANVI 78

Human   110 CIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKS-DLVEYSSMETI----LPIMNQY 169
            |:||:.|  :|.::|:..|:|...   .....:|::|..||| ||..|..:.||    :|::|::
pombe    79 CLVYSDN--YSYERVSIFWLPYFR---SLGVNVPIVLCENKSEDLDNYQGLHTIEHEMIPLINEF 138

Human   170 TEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGT 234
            .|||.|:.|||....|::||||..:..|::|..||:..:|:.|:.|.|.||:|||.:.|::||..
pombe   139 KEIEACILCSALEKINVNELFYMCRACVIYPITPLWDAKERTMRKATIHALSRIFFLIDKNNDDL 203

Human   235 LNDAELNFFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTW 299
            |:..|||.....||:..|:.:...::.:.|::...:||.:..|||.|||..:.:.::.|:.|:||
pombe   204 LSVDELNSLSEKCFSKNLSIEDASEILSKVKEICPEGVYEGQLTLPGFLAYNRVQVENGKQESTW 268

Human   300 TVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLF 364
            .:||.|.|.|.|.|...||.|..::.|....||:...|.||...|.:.|.|.|.||:.:||..||
pombe   269 GILRAFHYTDSLSLDDSYLSPKFEVAPGQIVELSPKGYRFLVDLFYQFDRDNDGALNNEELSALF 333

Human   365 KVFPYIP--W-GPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTE-QES 425
            :..|.:|  | .....|:...||.|::||.|:|:||::.|..|.:..|.||.|||:.  |: :..
pombe   334 RHTPGLPEIWVSSQFPNSTVLNEHGYVTYNGWLAQWSMITLFDYKTTLAYLAYLGFD--TDGRGH 396

Human   426 QASAVTVTRDKKIDLQKKQTQ--RNVFRCNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYY 488
            ...|:.|.| |::...:|.::  ||||.|.|:|.|:|||:.:|.:.:..|..|.       ....
pombe   397 NTDALKVMR-KRVSQNRKVSKYDRNVFLCFVVGSKSCGKTALLSSFINNNTNRL-------TPNT 453

Human   489 AINTVYVYGQEKYLLLHDISES--EFLTEAEII--CDVVCLVYDVSNPKSFEYCARIFKQHFMDS 549
            .:|:|.....::||:|.:|.|:  :.|.|.:.:  ||::||:||.|||.||.:.|.:...:....
pombe   454 VVNSVEFQSTQRYLVLSEIGETDLDILAEPKSLEACDILCLLYDSSNPNSFSFIANLLNLYPDLQ 518

Human   550 RIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYP 611
            :|||:..|.|:||...:|.|.:.|.:|.::..:|.|...:.......||:.|::|...|.||
pombe   519 KIPCVFAATKADLDRQQQRYPVQPDEFTKQLGLPSPTHISTAAIWNTSKEFFIQLAESAQYP 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT1	XP_047292309.1	Miro1	46..200	CDD:206680	56/159 (35%)
		EF_assoc_2	250..334	CDD:462444	27/83 (33%)
		EF_assoc_1	372..441	CDD:462443	24/70 (34%)
		Miro2	446..611	CDD:206679	53/170 (31%)
gem1	NP_587725.1	Miro1	2..169	CDD:206680	56/159 (35%)
		EF_assoc_2	219..303	CDD:462444	27/83 (33%)
		EF-hand_5	309..332	CDD:433035	9/22 (41%)
		EF_assoc_1	343..412	CDD:462443	24/71 (34%)
		Miro2	418..595	CDD:206679	55/170 (32%)