Protein Alignment RHOT1 and miro-1

DIOPT Version :10

• Sequence 1: XP_047292309.1
• Gene: RHOT1 / 55288
• HGNCID: 21168
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_500620.1
• Gene: miro-1 / 177238
• WormBaseID: WBGene00019544
• Length: 625
• Species: Caenorhabditis elegans
• Alignment Length: 680
• Identity: 272/680 - (40%)
• Similarity: 397/680 - (58%)
• Gaps: 83/680 - (12%)

Human    47 GKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICI 111
            |||||:|||:.:|:.:.||.|.:.:.||||||||.|.|.|||.|..|:.:..:..||.||||||:
 Worm    21 GKTSLVMSLLEDEWVDAVPRRLDRVLIPADVTPENVTTSIVDLSIKEEDENWIVSEIRQANVICV 85

Human   112 VYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCV 176
            ||:|.::.::|.:.::|:|||.:...:....|:||||||||... ::.:.|||||...||:||||
 Worm    86 VYSVTDESTVDGIQTKWLPLIRQSFGEYHETPVILVGNKSDGTA-NNTDKILPIMEANTEVETCV 149

Human   177 ECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELN 241
            ||||:.:||:||:||||||||::||.|||..:.|::.....|||.|:|||.|:||||.|:|.|||
 Worm   150 ECSARTMKNVSEIFYYAQKAVIYPTRPLYDADTKQLTDRARKALIRVFKICDRDNDGYLSDTELN 214

Human   242 FFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTWTVLRRFG 306
            .||::||..||...||||||..|.....||||:..|.|.|||:||.|||:||||||||.|||:||
 Worm   215 DFQKLCFGIPLTSTALEDVKRAVSDGCPDGVANDSLMLAGFLYLHLLFIERGRHETTWAVLRKFG 279

Human   307 YDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKVFPYIP 371
            |:..|.|:.:||:|.:.||..|:|||:.....|:.:.|:|:|.|:|..|||.||::||.|.|...
 Worm   280 YETSLKLSEDYLYPRITIPVGCSTELSPEGVQFVSALFEKYDEDKDGCLSPSELQNLFSVCPVPV 344

Human   372 WGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQA----SAVTV 432
            ...|....:.||:|||:||.|:::.|.:||.:::.:..|.|.|||:.:......:|    .::.|
 Worm   345 ITKDNILALETNQRGWLTYNGYMAYWNMTTLINLTQTFEQLAYLGFPVGRSGPGRAGNTLDSIRV 409

Human   433 TRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYG 497
            ||::|.||:...|.|.||:|.|:|.|:.||:..:|:|.||.:....:|...| |.:.||.|.|..
 Worm   410 TRERKKDLENHGTDRKVFQCLVVGAKDAGKTVFMQSLAGRGMADVAQIGRRH-SPFVINRVRVKE 473

Human   498 QEKYLLLHDI---SESEFLTEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAK 559
            :.|||||.::   |..:.|...|...|||..:||:|||.||.:||.:::::|..::.||:::|.|
 Worm   474 ESKYLLLREVDVLSPQDALGSGETSADVVAFLYDISNPDSFAFCATVYQKYFYRTKTPCVMIATK 538

Human   560 SDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPEDHYRDRLSRDMG 624
            .:..||.|.:.:.|.:|||:.::|.|..|:.......|..||.:|..||:||
 Worm   539 VEREEVDQRWEVPPEEFCRQFELPKPIKFSTGNIGQSSSPIFEQLAMMAVYP------------- 590

Human   625 HTDRIENLRKIWVFLKTAFHARLRCMCTCNRCTFCICQNFLN-SDLLQSVKNKIFTAVLNRHVTQ 688
                  :||:::                           :|| |:||..:
 Worm   591 ------HLRRVF---------------------------YLNDSNLLSKI--------------- 607

Human   689 ADLKSSTFWLRASFGATVFAVLGFAMYKAL 718
                        :|||.:.|:.||.:.|.|
 Worm   608 ------------TFGAAIVALAGFLVLKNL 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOT1	XP_047292309.1	Miro1	46..200	CDD:206680	79/152 (52%)
		EF_assoc_2	250..334	CDD:462444	48/83 (58%)
		EF_assoc_1	372..441	CDD:462443	23/72 (32%)
		Miro2	446..611	CDD:206679	61/167 (37%)
miro-1	NP_500620.1	Miro1	9..173	CDD:206680	79/152 (52%)
		EF-hand_7	190..>235	CDD:463900	28/44 (64%)
		EF_assoc_2	224..307	CDD:462444	48/82 (59%)
		FRQ1	<311..370	CDD:444056	24/58 (41%)
		EF_assoc_1	352..418	CDD:462443	22/65 (34%)
		Miro2	423..592	CDD:206679	63/188 (34%)