Protein Alignment FGGY and Gk1

DIOPT Version :10

• Sequence 1: NP_001106882.1
• Gene: FGGY / 55277
• HGNCID: 25610
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_524655.1
• Gene: Gk1 / 43913
• FlyBaseID: FBgn0025592
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 128/593 - (21%)
• Similarity: 224/593 - (37%)
• Gaps: 178/593 - (30%)

Human    12 YVG-VDVGTGSVRAALVDQSGV--LLAFADQPIKNWEPQFNHHEQS--------SEDIWAACCVV 65
            :|| :|.||.|.| .::.::|.  ::.|....:::...:....||.        :|.|..||
  Fly    19 FVGAIDEGTTSAR-FIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGAC--- 79

Human    66 TKKVVQGIDLNQIRGLGF-DATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINET 129
            .|.|..|..:.:|..:|. :...|.||.|:        ..|....|.|:|||:|..|.|..:.||
  Fly    80 KKLVAVGGKVEEIITIGITNQRESTVVWDR--------NSGQPLVNAIIWLDNRTTSTVEELLET 136

Human   130 ---KHSVLQYV----GGVMSVEMQAPKLLWLKENLREI--CWDKAGHFFDLPD-FLSWKATG--- 181
               ....:.|:    |..:|......||.||::|:..:  ..:|....|...| :|.:..||
  Fly   137 IPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKD 201

Human   182 -------VTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFV-------ADNYSKIGNQVLPPGA 232
                   ||..|...|:...|..    ||.:..|..||...:       ::.|..|..
  Fly   202 CGVHKTDVTNASRTMLMNIETLQ----WDANLLKFFGLPKTILPEICSSSEFYGSIAQ------- 255

Human   233 SLGNGLTPEAARDLGLLPGIAVAASLIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSS 297
                          |:|.||.:.:.|.|..|.        :.|...:.:||...:     .|| .
  Fly   256 --------------GVLQGIGITSVLGDQQAA--------LVGQQCLAKGQAKAT-----YGT-G 292

Human   298 CHMGISKDPIFVPGVWGPYFSA-------MVPGFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKA 355
            |.:..:..|..|....|...:.       .|| |:..||..|:.|          |||
  Fly   293 CFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVP-FYALEGSVSIAG----------AAF------- 339

Human   356 TARCQSIYAYLNSHLDLIKKAQPVGFL------TVDLHVWPDFHGNRSPLADLTLKGMRTTGYLY 414
                    .:|..:::||:.:..:..:      ::|::..|.|:|..:|..:...:|:
  Fly   340 --------NWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGV------- 389

Human   415 IPALAALHSPSSLLSPQVTGLKLSQDLDDLAILYLATVQAIALGTRFIIEAMEAAGHS-----IS 474
                             :.|  ||::.....|: .||::|:....|.|:::|    |.     ::
  Fly   390 -----------------ICG--LSEETTSEHIV-RATLEAVCFQVRDILDSM----HKDCKIPLA 430

Human   475 TLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAVLGACASGDFASVQ---EAMAKMSK 536
            .|.:.||::.|.||:|:.:|:.|:.|:.::..|:..:|||:..      :.:|:   :..|.:||
  Fly   431 KLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAA------YKAVENRYQMEAPLSK 489

Human   537 VGKVVFPR 544
            .|    ||
  Fly   490 SG----PR 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGGY	NP_001106882.1	ASKHA_NBD_FGGY_D-RBK	11..568	CDD:466800	128/593 (22%)
Gk1	NP_524655.1	ASKHA_NBD_FGGY_GK1-3-like	18..519	CDD:466802	128/593 (22%)