Protein Alignment FGGY and Gk2

DIOPT Version :10

• Sequence 1: NP_001106882.1
• Gene: FGGY / 55277
• HGNCID: 25610
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_647655.1
• Gene: Gk2 / 38221
• FlyBaseID: FBgn0035266
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 129/582 - (22%)
• Similarity: 209/582 - (35%)
• Gaps: 188/582 - (32%)

Human    46 PQFNHHEQSSEDIWAACCVVTKKVVQGIDLNQIRGLGFDATCSLVVLDKQFHPLPVNQE------ 104
            ||...:||...::.|:   :.|...:.|  .|:...||.|: .:|.:.      ..||.
  Fly    68 PQDGWYEQDPLEMMAS---INKCAEEAI--KQLPEQGFSAS-DIVTVG------ITNQRETTIVW 120

Human   105 ----GDSHRNVIMWLDHRAVSQVNRI-------NETKHSVLQYVGGVMSVEMQAPKLLWLKENLR 158
                |....|.::|.|.|..:.|.:|       |..:.|    .|..:|....|.|:.||::|:.
  Fly   121 DAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHFRSS----TGLPISTYFSALKIRWLRDNVP 181

Human   159 EI--------CWDKAGHFFDLPDFLSWKATG-------VTARSLCSLVCKWTYSAEKGWDDSFWK 208
            |:        |  |||   .:..::.|..|.       ||..|...|:...|    :.||....|
  Fly   182 EVRQAIRERRC--KAG---TVDSWIVWNLTNGALHITDVTNASRTLLMNLET----QAWDPVLLK 237

Human   209 MIGLEDFV-------ADNYSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAASLIDAHAGGL 266
            ..|:.:.:       ::.:.||.::..|                   |.|:.::
  Fly   238 TFGIREEMLPTIHSCSEIFGKITSERSP-------------------LRGMTLS----------- 272

Human   267 GVIG---ADVRGHGLICEGQ---PVTSRLAVICGTSSCHMGISKDPIF--------VPGVWGPYF 317
            |::|   |.:.|...:..||   ...|...::|.|..       .|:|        |....||
  Fly   273 GIMGNQQASLLGQMCVKPGQTKNTYRSGCFLLCNTGD-------KPVFSRHGLLTTVAYKLGP-- 328

Human   318 SAMVPGFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQSIYAYLNSHLDLIKKAQPVGFL 382
              ..|..:..||..||.         |||                                :.:|
  Fly   329 --QAPTIYAIEGAVSVA---------GHA--------------------------------LSWL 350

Human   383 TVDLHVWPDFHGNRSPLADLTLKGMRTTGYLY-IPALAALHSPSSLLSPQVTGLKLSQDLDDLAI 446
            ...:.:.||     |..|:...:.:.|:|.:| :||...|::|....:.:...:.|:|......|
  Fly   351 QNKVRILPD-----SRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHI 410

Human   447 LYLATVQAIALGTRFIIEAM-EAAGHSISTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVL 510
            : .|.:::|...||.|:|.| :..|:.|:.|...|.|:.|.|.:|:.||..||||..||.::|..
  Fly   411 V-RAALESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTA 474

Human   511 VGAAVLGACASGDFASVQEAMAKMSKVGKVVFPRLQDKKYYDK-KYQVFLKL---VEHQKEY 568
            .|||:..|.|.|              |....|.  .:|:||:. .|..||..   ||.::.|
  Fly   475 FGAAMCAAQADG--------------VNLCQFE--PEKRYYENVHYDTFLATTTDVERKERY 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGGY	NP_001106882.1	ASKHA_NBD_FGGY_D-RBK	11..568	CDD:466800	128/580 (22%)
Gk2	NP_647655.1	glycerol_kin	31..533	CDD:273549	129/582 (22%)