Protein Alignment PSPC1 and nonA-l

DIOPT Version :10

• Sequence 1: NP_001035879.1
• Gene: PSPC1 / 55269
• HGNCID: 20320
• Length: 523
• Species: Homo sapiens
• Sequence 2: NP_536740.1
• Gene: nonA-l / 42026
• FlyBaseID: FBgn0015520
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 391
• Identity: 152/391 - (38%)
• Similarity: 233/391 - (59%)
• Gaps: 27/391 - (6%)

Human    62 GFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLES 126
            |.|.::.....|.:..:..|.||:||||.:|.|::|.:.:|:.|||..::|.|.::.|.|:||:.
  Fly   245 GPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDY 309

Human   127 RTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDD 191
            ...||.||..|||::.|.|.||:|||.: |.:.|.||:..||||||.|:|..|||:|:||:.|||
  Fly   310 YQNAEKAKRALDGSLRKGRVLRVRFAPN-AIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDD 373

Human   192 RGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEK-LMQKTQQY 255
            ||:.||:|.||||.|..|...|..|.:..|.||.:.||.:|||||..:|.||||:| |.:|:.::
  Fly   374 RGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEF 438

Human   256 HKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLM 320
            ..||...||||...:||.||.||||.|.::.|.:::.:.|.::..::||||:||.||:|.:..|:
  Fly   439 RHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELL 503

Human   321 RQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYME 385
            ||:|.:|        ||.|:.::...:::.:..||.|:||||.: ||.|.:|.|.:|..:....|
  Fly   504 RQELKKR--------ELDNERMKLEWEMREKQAEEIRKREEEYM-HRYQNQLLRHEEDMRARQQE 559

Human   386 N----REQEMRMGDMGPRGAINMGDAFSPAPAGNQ---GPPPMMGMNMNNRATIPGPPMGPGPAM 443
            |    :.:::.|       .::..:.|..:.:|.:   .|..:.|.|.|| :|:.||. ||..:.
  Fly   560 NDLLMQAKKLNM-------ILDQQEGFGGSNSGFEHFDSPFEVFGNNSNN-STMAGPG-GPDNSD 615

Human   444 G 444
            |
  Fly   616 G 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSPC1	NP_001035879.1	RRM1_PSP1	81..151	CDD:409999	31/69 (45%)
		Sufficient for paraspeckles localization. /evidence=ECO:0000269|PubMed:16148043	125..358		102/233 (44%)
		RRM2_PSP1	157..236	CDD:410002	41/78 (53%)
		NOPS_PSPC1	227..320	CDD:240584	41/93 (44%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269|PubMed:16148043	231..358		49/127 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..523
nonA-l	NP_536740.1	PRK12678	3..>219	CDD:237171
		Med15	<90..>191	CDD:312941
		RRM1_p54nrb_like	264..334	CDD:409769	31/69 (45%)
		RRM2_p54nrb_like	339..418	CDD:409770	41/78 (53%)
		NOPS_NONA_like	409..508	CDD:240580	44/98 (45%)
		APG6_N	<477..555	CDD:465452	31/86 (36%)