Protein Alignment LRRC1 and scrib

DIOPT Version :10

• Sequence 1: NP_060684.4
• Gene: LRRC1 / 55227
• HGNCID: 14307
• Length: 524
• Species: Homo sapiens
• Sequence 2: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 286/505 - (56%)
• Similarity: 369/505 - (73%)
• Gaps: 17/505 - (3%)

Human     1 MFHCIPLWR-CNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKL 64
            ||.|||::: |||.||.:|||||||..|||||.||:|:||||.||||.:|:||:.||:|.:||||
  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65

Human    65 GLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQN 129
            |||||||.||||:|.||..|||||||||:||:||:.|...::|||||||.||:.:||..|.:|:|
  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130

Human   130 LTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIG 194
            ||.|.:||:||.:||.:.|:|..|.|||||||||.:||::::||.:|:.||||:|||.:||..:|
  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195

Human   195 ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
            .|..|.:||||.|||..||.|:|.|..|..|||||||||.||.|||||.|||||.::|||||.:|
  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260

Human   260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKL 324
            |||.||.:|:|||:|||||.:|.:.:|.||::.||:||||.|..||.|||::.||:|||.|||.|
  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325

Human   325 VSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSD 389
            ..||.|||.|.:|.|..:|||:|.::|.|:...|.||||||:||:||:||.||..|:|||:|||:
  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390

Human   390 NQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNERAVNR 454
            ||||||||||.|||..|||::|:|.||||       ||..|...| .:|.:|  .|.:.||..:|
  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQ-------QEYQPITPA-RDLESD--SEPFEEREPSR 445

Human   455 VSAIRFVEDEKDEEDNETRTLLRRATPHPGEL--KHMKKTVENLRNDMNA 502
             :.::|.|:...|::.   ..:|:.||||.:|  |..|..||..||:.:|
  Fly   446 -TVVKFSEEATQEKET---PFVRQNTPHPKDLKAKAQKLKVERSRNEEHA 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRRC1	NP_060684.4	LRR 1	11..34		16/22 (73%)
		PRK15370	<23..>125	CDD:185268	67/101 (66%)
		LRR 2	35..58		14/22 (64%)
		leucine-rich repeat	38..60	CDD:275380	14/21 (67%)
		LRR 3	60..81		16/20 (80%)
		leucine-rich repeat	61..83	CDD:275380	18/21 (86%)
		LRR 4	83..105		14/21 (67%)
		leucine-rich repeat	84..106	CDD:275380	14/21 (67%)
		leucine-rich repeat	107..129	CDD:275380	13/21 (62%)
		LRR 5	107..126		12/18 (67%)
		LRR 6	127..149		11/21 (52%)
		leucine-rich repeat	130..152	CDD:275380	11/21 (52%)
		LRR	133..424	CDD:443914	173/290 (60%)
		LRR 7	150..172		13/21 (62%)
		leucine-rich repeat	153..175	CDD:275380	14/21 (67%)
		LRR 8	173..196		12/22 (55%)
		leucine-rich repeat	176..198	CDD:275380	12/21 (57%)
		LRR 9	198..218		11/19 (58%)
		leucine-rich repeat	199..221	CDD:275380	13/21 (62%)
		LRR 10	219..242		16/22 (73%)
		leucine-rich repeat	222..244	CDD:275380	17/21 (81%)
		LRR 11	244..264		14/19 (74%)
		leucine-rich repeat	245..267	CDD:275380	15/21 (71%)
		LRR 12	265..288		12/22 (55%)
		LRR 13	290..310		11/19 (58%)
		leucine-rich repeat	291..313	CDD:275380	12/21 (57%)
		LRR 14	311..334		14/22 (64%)
		leucine-rich repeat	314..336	CDD:275380	14/21 (67%)
		LRR 15	336..356		8/19 (42%)
		LRR 16	357..380		15/22 (68%)
		leucine-rich repeat	360..381	CDD:275380	14/20 (70%)
		LRR 17	382..405		19/22 (86%)
scrib	NP_001163746.1	leucine-rich repeat	18..38	CDD:275380	14/19 (74%)
		LRR_8	37..95	CDD:404697	42/57 (74%)
		leucine-rich repeat	39..61	CDD:275380	14/21 (67%)
		leucine-rich repeat	62..84	CDD:275380	18/21 (86%)
		LRR	67..408	CDD:443914	207/340 (61%)
		leucine-rich repeat	85..107	CDD:275380	14/21 (67%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		leucine-rich repeat	131..153	CDD:275380	11/21 (52%)
		leucine-rich repeat	154..176	CDD:275380	14/21 (67%)
		leucine-rich repeat	177..199	CDD:275380	12/21 (57%)
		leucine-rich repeat	200..222	CDD:275380	13/21 (62%)
		leucine-rich repeat	223..245	CDD:275380	17/21 (81%)
		leucine-rich repeat	269..289	CDD:275380	11/19 (58%)
		leucine-rich repeat	292..314	CDD:275380	12/21 (57%)
		leucine-rich repeat	315..337	CDD:275380	14/21 (67%)
		leucine-rich repeat	361..382	CDD:275380	14/20 (70%)
		PDZ1_Scribble-like	730..816	CDD:467188
		PDZ2_Scribble-like	927..1019	CDD:467187
		PDZ3_Scribble-like	1238..1327	CDD:467186
		PDZ4_Scribble-like	1331..1428	CDD:467185