Protein Alignment SETD5 and upSET

DIOPT Version :10

• Sequence 1: XP_047304422.1
• Gene: SETD5 / 55209
• HGNCID: 25566
• Length: 1500
• Species: Homo sapiens
• Sequence 2: NP_648681.1
• Gene: upSET / 39551
• FlyBaseID: FBgn0036398
• Length: 3146
• Species: Drosophila melanogaster
• Alignment Length: 2275
• Identity: 412/2275 - (18%)
• Similarity: 667/2275 - (29%)
• Gaps: 942/2275 - (41%)

Human    37 ASPAVNEKSVYSTHNYGTTQRHGCRGLPYADH---NYGAPPPPTPPASPPVQTIIPRSDLNGLPS 98
            |:..|.:...:|....|.|. .|.:|.|.|..   :|.........|.....:.|..|...||.|
  Fly   769 AAQQVQQPQQWSLGGIGVTV-SGSQGTPTAVGGYCSYFGQQIARSQADDDAHSAISSSSRMGLAS 832

Human    99 PVEERCGDSPNSEGETVP---------TWCPCGLS-QDGFLLNCDKC------------------ 135
                 ....|..|.||.|         |.|.|.|: .||:::.||||
  Fly   833 -----TDIDPGEETETAPEAEAEDDSVTRCICELTHDDGYMICCDKCSAWQHVDCMGIDRQNIPE 892

Human   136 ---------RGMSRGKVIRLHRRKQ---------------------DNISGGDSSATESWDEELS 170
                     |.:.:.:...|.|:|:                     ..:|||..|.. ...|||
  Fly   893 EYMCELCQPRAVDKARARALQRQKRKEHMLLVATQAANGAAAVAAGTTLSGGLGSGL-PMSEEL- 955

Human   171 PSTVLYTATQH-----------TPTSITLTVRRTKP--------KKRKKSPEKGRAAPKTKKIKA 216
                     ||           |.|.::...::||.        ||.||| ..|....|......
  Fly   956 ---------QHRLASGLNGGFATGTGMSKKSKKTKENSGSTSTLKKTKKS-AVGMGGEKNASGSG 1010

Human   217 FREGSRKSLRMKNSPSEAQNLDENTTEGWEN-----------RIRLWTDQYEEAFTNQYSADVQN 270
            ...||......|:|..::::..:.::.|..:           .:|.|.:.||.|.||.||.:
  Fly  1011 TPTGSSGKTSKKSSKRKSKSGGDGSSGGGSSPALTAAEKHAANLRQWIENYEYAVTNHYSPE--- 1072

Human   271 ALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQ-LGRVTRVQKH--------RKILR 326
             |...||:.::   :|::|.:|..||   |..:...|.||. .|...::::.        .|:|.
  Fly  1073 -LRARLHAIQK---QPSLLQSIQNTE---NKALRQIQQQLSTAGSAEQLEQRAQLIPYAGAKVLI 1130

Human   327 AARDLALDTLIIEYRGKVMLRQQFE-----VN--------------GHFFKKPYPFVLFY----- 367
            ::.||:....|.|.|||.||..||.     ||              .|  |.|..||.||
  Fly  1131 SSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPSNYLNSFKAH--KTPGQFVFFYQLPGV 1193

Human   368 ---------------------SKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLC 411
                                 |...|.|:|||.||:||||||:||||.||||::|....|.:||.
  Fly  1194 EAPMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGNDARFVRRSCRPNAELQHYFEKGTLHLY 1258

Human   412 IYAVSAITKDAEVTI--------AFDYEYSNCNY----KVDCACHKG------------------ 446
            |.|::.|....|:||        |.:.:.|:...    ...|||..|
  Fly  1259 IVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPTSTRCACDMGSDCLFALPLAVQQQLQAP 1323

Human   447 ----------------------------------------------------------------- 446
                                                                             
  Fly  1324 PTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGATVAAGASVLPNSRNRSTSSSGESSQMG 1388

Human   447 -----------------------------------------NRNC-------------------- 450
                                                     |.:|
  Fly  1389 LNSPQLGQLNLGFKTSVTATSLTAPVPGVHCNNSGGSSSSSNNSCSVSMSSVLHDSGICTSSSSP 1453

Human   451 --------PIQKRNPNATELP-------------------------LLPPPPSLPTIGAETRRRK 482
                    |.|.::|...:.|                         .||.|...|.:..:..:..
  Fly  1454 SVSIPSPTPTQMQSPTLQQHPQQIPQQQLSLLQRSPTQQHQQQILAALPTPMLTPMLSPQLPKPA 1518

Human   483 ARRKELEMEQQNEAS--EENNDQQSQEVPEKVTVSSDHEE------VDNPEE-------KPE--- 529
            .::..:.:.|..:.|  ::...|||||....:..::..::      |..|::       ||:
  Fly  1519 QQQAHVVLPQSQQTSLLQQQQSQQSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALV 1583

Human   530 ---------EEKEEVIDDQENLAHSRRTREDR---------------------KVEAIMHAFENL 564
                     ::::..:..|:.....:...|.|                     ||.|:....:..
  Fly  1584 AQQQHVVGAQQQQHFLQQQQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQ 1648

Human   565 EKRKKRRDQP------------LEQSNS----------------------DVEITTTTSETPVGE 595
            ::::....||            |:|..|                      .:.|:|.....|...
  Fly  1649 QQQQNTHQQPHNQQAVQQQSNQLQQQQSQQPNYPQSPQRQQKPQPVQHQPQIVISTGAQAIPATM 1713

Human   596 ETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRS------------------------------- 629
            .||..:|....:..:||..|..:.||..|..:::
  Fly  1714 PTKLSSPTKSAAPVISNNNITVSAQSSVVGGKKTPAKHPQQQQQQQQQPVTPVSAATAPAATPSS 1778

Human   630 --SQAGDIAAEKLVPKPPPAKPSRPRPK-SR-----------ISRYRTSSAQRLK--RQKQANAQ 678
              |:..|::|.. ...|....|::.:|| ||           |.:.....|:..|  ||.....:
  Fly  1779 SESKEDDVSASS-TTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEARGKKDTRQSSGGKR 1842

Human   679 QAELSQAALEEGGSNSLV-----TPTEAGS----------------------------------- 703
            ||..|.|:..:..|::.:     |||...|
  Fly  1843 QASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQRRNKKKRKVSRSLNNNTNGLGSGGGSNNK 1907

Human   704 ------LDSSGENRPLTGS-----------------------------------DPTVVSITGSH 727
                  ::|.||:..||.|                                   :|....::.||
  Fly  1908 RRKSIVVESDGESHALTNSESEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSH 1972

Human   728 ---------------------------------VNRAASKYP----KTKKYLVTEWLNDKAEKQE 755
                                             .:.|..|||    ||||.|::.|. .:||:|.
  Fly  1973 SLPATPASVSSACLLIEAAMGPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWF-QQAEQQH 2036

Human   756 CP-----VECPL--------RITTDP---TVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPE 804
            ..     |:..:        ::...|   ::.|..|..:...||.....|.           :|.
  Fly  2037 ASGLDSLVQAAMSEINGEREQLQRQPQGESLPAPALLKVEQFIHQAESTTA-----------VPA 2090

Human   805 RRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSP 869
            |.:.. ||....||.||||::||:.|         :.|....|.||...|.:::........:||
  Fly  2091 REQLH-LPLQNNSSVKKRWLRQAISE---------ETTPVDELQQSQNQSVTATPSPQPVPTVSP 2145

Human   870 LKKW------KSRYLMEQNVTKLLRPLS--PVTPPPPNSGSKS---PQLATPGSSHPGEEECRNG 923
            |...      |.|.::..|.|.:....:  .|...|.:...::   .:|.....:|..|::  :.
  Fly  2146 LANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAEENVAMTELKVEIENHHQEQD--DD 2208

Human   924 YSLMFSPVTSL----------------TTASRCNTPL-----------QFENISSPESSPAHRPE 961
            ..::.||....                |:|:..:..:           :||.:...:.....:.|
  Fly  2209 VDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVEREESQACDKFEEMVKVKREEEEQRE 2273

Human   962 SLSPELCHRKDLDLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPSLGPTSE------------- 1013
            ....:|..|::.:..||       ......|.|.|   :.....|.:.|:.|
  Fly  2274 KEIKQLQERQEHEQPKV-------EPAPVEPKLEN---TVAKAEPKVEPSQEIVSKKEPTKVEPK 2328

Human  1014 ------------TGFPSRSGDGHQTLVRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGD 1066
                        |..|:.:.....||:..|..||:|...|.....|....|:.:.:....  |..
  Fly  2329 PGESLLRSTATVTATPTAATIAATTLLDVSKVAFKTRPPLKLEDEPQKKKPKLESILPAP--VAT 2391

Human  1067 RKPLHLDGGYCSPAEGFSSRYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPPQR---------- 1121
            ..|:.:      |....:|......:.:.:..||:      ....||:.:|..:.
  Fly  2392 VPPVSV------PPIPAASNATTSAVTNTAAASLT------TTTAPSSTKNLTEHDIQERLLSFH 2444

Human  1122 -KKVSLLEYRKRKQEA---------KENSAGGGGDSAQSKS------------------------ 1152
             ..:|.|:.|.:|..|         |.||:.||..:...||
  Fly  2445 AANISYLQSRNKKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKS 2509

Human  1153 -----KSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFS-------PS-----------HSS 1194
                 :.|.....|::.:.||.....|      ||.|..|.|       ||           |::
  Fly  2510 KDKEKQKAAVNVNSTSQIVDTKKKTTQ------PSKPDSKSSIAPVLVPPSLPVATANGKTKHTA 2568

Human  1195 MSHLE-----------------------AVSPSDSRGTSSSHCRPQENISSRWMVPTSVERLREG 1236
            .::::                       .|:||...||..|..:.|.|.......|.|
  Fly  2569 YNNVDQQQQQQMRRRTMSMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNS------- 2626

Human  1237 GSIPKVLRSSVRV-AQKG----EPSPTWESNIT------------EKDSDPADGEGPETLSSALS 1284
                ::|.||:.: :.||    ..:||..|..|            .:::.||.| ||.:|::|::
  Fly  2627 ----QILSSSILLNSSKGLGLPLAAPTVVSVPTAVQQQQHRKENNHQEATPASG-GPMSLAAAIA 2686

Human  1285 KG-ATVYSPSRYSYQLLQCDSPRTESQSLL--------------QQSSSPFRGHPTQSPGYSYRT 1334
            .| ....|..|.|    .|.|  .:.|:|:              ::.....:.|..|......|.
  Fly  2687 SGKLNAISRRRES----MCGS--RQQQALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKERE 2745

Human  1335 TALRPGN--------PPSHGSSESSLSSTSYSSPA-------HPVSTDSLAPF-------TGTPG 1377
            ......|        .|:|.::..: :|...|:||       .||:|...||.       |.:|.
  Fly  2746 KDKEKDNKQKTNHIQKPAHPTTVPA-NSMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPI 2809

Human  1378 YFSSQPHSGNSTGSNLPRRSCPSSAAS--------PTLQGPSDSPTSDSVSQSST-----GTLSS 1429
            :. :||...|          |.:..||        ..||.|| :|||..:..::|     ..|.|
  Fly  2810 HV-TQPLVNN----------CSTKVASLPFYNTIYGKLQDPS-TPTSSPIPVTNTMPSLAEYLES 2862

Human  1430 TSFPQNSRSSL-PSDLRTIS-LPSAGQSAVYQASRVS----AVSNSQHYPHRGSGGVHQYRLQPL 1488
            |.....:.|:: |..:..:: |.||...|....|.:.    |.:..:.|....|   |..||.|:
  Fly  2863 TKSKTTALSAVKPIGIAAVTPLSSAITPAKVAPSSLEMPPPATTPLKLYTRTAS---HDPRLNPM 2924

Human  1489  1488
              Fly  2925  2924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETD5	XP_047304422.1	SET_SETD5	305..454	CDD:380958	67/366 (18%)
		COG5644	<473..>693	CDD:227931	52/348 (15%)
		ser_rich_anae_1	<1134..>1213	CDD:468206	26/157 (17%)
		PLN02217	<1360..1467	CDD:215130	34/139 (24%)
upSET	NP_648681.1	PHD_MLL5	856..899	CDD:277025	9/42 (21%)
		SET_SETD5-like	1112..1276	CDD:380927	54/165 (33%)