Protein Alignment PLEKHG6 and CG42674

DIOPT Version :10

• Sequence 1: NP_001371533.1
• Gene: PLEKHG6 / 55200
• HGNCID: 25562
• Length: 806
• Species: Homo sapiens
• Sequence 2: NP_649182.4
• Gene: CG42674 / 40205
• FlyBaseID: FBgn0261556
• Length: 1661
• Species: Drosophila melanogaster
• Alignment Length: 826
• Identity: 209/826 - (25%)
• Similarity: 337/826 - (40%)
• Gaps: 183/826 - (22%)

Human    20 IETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHG 84
            :|:..|.|....:        ||     .:|:.||:...|  ||.|.   .|..|.....|:...
  Fly   895 VESLAGHHLCITE--------RG-----SNRKPLQKAASF--GSRQP---PPRLLPSVSTEETSE 941

Human    85 GHVGAGL-----------LHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSG 138
            ..|..|.           :.:|:..:|.:.      |::::..|:|:.|  |...::..:..:|.
  Fly   942 SGVAPGKQIKQRWSSIFGIKNPQQSQLCEL------LNSYAKNGVPQRP--DSMSFDHPDLVNSL 998

Human   139 LTIE---KSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLL 200
            ..::   ||||:.| ....||:.....|.|:|||:|||:.|:..|:.:|||..|.|..:|..|||
  Fly   999 AYLQYMHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEEGLL 1062

Human   201 MEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCL 265
            ::|....||.||.::...:..||...|.|.:..:..:.:||.....|.|||:|...|.||..||.
  Fly  1063 IDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCA 1127

Human   266 RVKQTMAYAREQQETNPLFHAFVQAGQEGANPEPHPPSLQWCEKHKRSGRQMLCDLLIKPHQRIT 330
            .......|.:|....|.||.::                |.|||..|...|..|.|::::|.||:|
  Fly  1128 EQSTCQFYCKELNHNNALFTSY----------------LAWCESQKMCNRLRLADIVVRPMQRLT 1176

Human   331 KYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPP 395
            ||.|||.|:.|...:....||::.|:.:||:|:..:|..:...:|.|.|.....||..|:|::..
  Fly  1177 KYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESYDVVDTN 1241

Human   396 SDEVEKNLRPFSTL-DLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK-- 457
            ::.::|.::..|.: ||.:||.|..:.|.|.|.:||..:.|:.. ||.||:.||.:|:|||.|
  Fly  1242 NEVLDKMIKQNSQMFDLCAPMRGCPAYHVRHLFMEGDHKFKDNL-GKSDVHCFLLTDLLLVCKTI 1305

Human   458 PQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQ 522
            .:|.....||||.|.:.::|:.| |...|:...::|.|||..::|..:.|   |:...|.:...:
  Fly  1306 AKRGLGALKVIRQPYLTDQLIVQ-LAPNNTLNCVYLNEFQVATTAFTLQC---TEAKNWYDALWR 1366

Human   523 AQAALQKLK-------------------------------------------------------- 531
            |:...|:||
  Fly  1367 AKTIYQRLKRGGGGGGSGSGTVGGGDSFRFGGSATSGGTADSLGVRKSPMNSSICSHVSSANNSH 1431

Human   532 --AEEYVQQKR-----ELLTLYRDQDRESPSTRPSTPSLEGSQSSAEG------------RTPEF 577
              :.|:...:.     |........:..|..|.....:|:|.|....|            .:...
  Fly  1432 SGSVEWNDSRNISVDFEKTNSVSSDEGSSIMTGNHGVNLKGKQQLISGLHKTKMGIIGQMGSKSA 1496

Human   578 STI-----------IPHLVVTEDTDEDAPLVP-DDTSDSGYGTLIPG-------TPTGSRSPLSR 623
            :|:           :|:|.:......:..||| ..||.||...|.|.       .|:.:|.||.|
  Fly  1497 NTLSVQPMNHLGQSLPNLNMHHSHTNNTLLVPGSTTSHSGNMLLSPSHRGISYPPPSPTRVPLRR 1561

Human   624 -------LRQRALRRDPRLTF-STLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDP 680
                   .:...||:...:|. :::....||..|.||.|     ||..:.|..:....|||.. .
  Fly  1562 GMAFSTSTKNPPLRKTRNITSQNSINWHQIPATPTPPSP-----RSQYQSPGVVCMQKSLPLL-L 1620

Human   681 PTWSEEEDGASERGNVVVETL-HRARLRGQLPSSPT--HADSAGES 723
            ||.::|..|.::....:.:.| |:|.|       ||  |..|:.|:
  Fly  1621 PTNTDEGQGPTQPPPPLQKQLSHQAPL-------PTTIHNQSSTET 1659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHG6	NP_001371533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		6/27 (22%)
		RhoGEF	165..367	CDD:459876	69/201 (34%)
		PH_PLEKHG5_G6	424..522	CDD:270064	34/99 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..693		42/186 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..746		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..806
CG42674	NP_649182.4	Ubl1_cv_Nsp3_N-like	830..908	CDD:475130	3/20 (15%)
		RhoGEF	1027..1213	CDD:459876	69/201 (34%)
		PH_PLEKHG5_G6	1271..1366	CDD:270064	34/99 (34%)