Protein Alignment PLEKHG6 and RhoGEF2

DIOPT Version :10

• Sequence 1: NP_001371533.1
• Gene: PLEKHG6 / 55200
• HGNCID: 25562
• Length: 806
• Species: Homo sapiens
• Sequence 2: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Alignment Length: 769
• Identity: 164/769 - (21%)
• Similarity: 264/769 - (34%)
• Gaps: 178/769 - (23%)

Human    22 TYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRL-RDPEPE---KR 82
            ||.|...:|..|..|.        ..||........|.|.|..|   :.||.| ::..|.   ::
  Fly  1411 TYVGSSNSSLSSAGGS--------ESPSTSMEHFAAPGAAGGVQ---VPPMGLNQNQHPHLLIQQ 1464

Human    83 H-----------GGHVG-AGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGG 135
            |           .|..| ||...:.........|.|.|...|        |..||..  ::.|..
  Fly  1465 HAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWT--------LESEDED--DVNEAD 1519

Human   136 DSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLL 200
            .|.:...:....|....|:       :||.:.|:..||..:||.||::..|.   .|.|...|||
  Fly  1520 WSSMVAAEVLAALTDAEKK-------RQEIINEIYQTERNHVRTLKLLDRLF---FLPLYESGLL 1574

Human   201 MEVSAETLFGNVPSLI---RTHRSFWDEVLGPTLEE---TRASGQPL-DPIGLQSGFL--TFGQR 256
            .:.....||  .|:|:   ..|.:|...:....:|.   ....|..| |....|||.:  .|.
  Fly  1575 SQDHLLLLF--PPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA-- 1635

Human   257 FHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQAGQEGANPEPHPPSLQWCEKHKRSGRQMLCDL 321
                .|:|.|.:..:...:|::..:.:....                |:..|.||...|..|.||
  Fly  1636 ----AQFCARQQIALEALKEKRNKDEMLQKL----------------LKKSESHKACRRLELKDL 1680

Human   322 LIKPHQRITKYPLLLHAVLKRS----PEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAA 381
            |....||:||||||...:.|.:    ||...: ||:...:|:.:..|..:|..|:..|:...|..
  Fly  1681 LPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQN 1745

Human   382 AAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYL 446
            ..:::          |....:...|..||||        :|  .|:.:|.:.:|  :...:.::.
  Fly  1746 IQRKL----------DRSSYDKEEFKKLDLT--------QH--HLIHDGNLTIK--KNPSVQLHG 1788

Human   447 FLFSDVLLVTKPQRKADKAKVIRPPLML-------------EKLVCQPLRDPNSFLLIHLTEFQC 498
            .||.:::::...|......|.:..||.:             :.|:.|...|.|||.||.:.
  Fly  1789 LLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMK---- 1849

Human   499 VSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSL 563
            .|..|.:..||.::...|.:......|...|.:::               ....:..|..|.|:|
  Fly  1850 TSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSK---------------NASSNHDTSISDPAL 1899

Human   564 EGSQSSAEGRTPEFST-IIPHLVVTE--DTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLR 625
            .....|....:.|.|| .:..|..|.  .|...||::|..|.     |..|.|...:.|.|:.::
  Fly  1900 AAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATV-----TPAPATNNSNVSSLTGVQ 1959

Human   626 QRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGA 690
            .|..:||...:.|..:..:.| :|.....:..:..|.....|.|.|..:              ..
  Fly  1960 LRNPQRDATASESDADYVNTP-KPRSSQNEVNRTMSIRSTGEPIQKYSA--------------NG 2009

Human   691 SERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHT 744
            :|..:|.:.                |:.|..||....|..||......:..|::
  Fly  2010 TEANDVTLR----------------HSQSTRESVRPGSTGEERNSTYGMVGGNS 2047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHG6	NP_001371533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		9/43 (21%)
		RhoGEF	165..367	CDD:459876	55/215 (26%)
		PH_PLEKHG5_G6	424..522	CDD:270064	22/110 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..693		30/150 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..746		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..806
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282
		RGS_GEF_like	934..1055	CDD:188710
		C1_ARHGEF-like	1150..1202	CDD:410382
		RhoGEF	1539..1731	CDD:238091	57/218 (26%)
		PH_16	1756..1876	CDD:436083	28/135 (21%)