Protein Alignment PLEKHG6 and cyst

DIOPT Version :10

• Sequence 1: NP_001371533.1
• Gene: PLEKHG6 / 55200
• HGNCID: 25562
• Length: 806
• Species: Homo sapiens
• Sequence 2: NP_001260588.1
• Gene: cyst / 35237
• FlyBaseID: FBgn0032796
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 875
• Identity: 174/875 - (19%)
• Similarity: 309/875 - (35%)
• Gaps: 239/875 - (27%)

Human    67 RGLSPMRLRDPEPEKRH--GGHVGA-----GLLHSPKLKELTKAHELEVRL-------------- 110
            ||....|.:.|:.:.:.  ||.:.|     ..:...::||    |.||.::
  Fly   318 RGSIFFRKKKPKAKTKSLVGGQLSACDVCGAAITLAQIKE----HHLECKVKKMGGGQDYYDGPD 378

Human   111 -HTFSMFGMPRLPPEDR---------------RHWEIGEGGDSGLTIEK--SWRELVPGHKEMSQ 157
             .|||       .|||:               ...::|.....|:.:::  ||...||  :|:.:
  Fly   379 ASTFS-------NPEDQPLIRSDLQFLNEAPIEAQDLGADPVLGIVLKEHDSWTPNVP--RELLK 434

Human   158 EL----CHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRT 218
            .|    ..:||.::|.:.||..:.:.|.:|                 .:|..|:|..:.||| ..
  Fly   435 TLKDLQIKRQEHIYEFIMTEKHHCQTLIVM-----------------QKVFVESLERHFPSL-NL 481

Human   219 HRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPL 283
            :..|      |.|::.         ..|.:.||.           .||:||     |||...:.:
  Fly   482 NSMF------PRLQQL---------TDLHTCFLR-----------QLRLKQ-----REQHMVDSI 515

Human   284 ------FHAFVQA-------GQEGANPE----------PHPPSLQW---CEKHKRSGRQMLCDLL 322
                  |.:..||       |:..||..          ..|...:|   |.::....::.:.:.:
  Fly   516 ADILLDFFSLEQAQCLRLAYGEFCANHRSALDQFKLCLTEPSFAEWYKHCLQNPLLKKKGIPECI 580

Human   323 IKPHQRITKYPLLLHAVLKRSPEARAQ-EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRI 386
            :...||:||||||:..:||.:.:.:.: :.|...:..|:|.|..::..|.:.|.:|      :::
  Fly   581 LFVTQRLTKYPLLIEPLLKSARDNKLETDKLQHALNLVKSLLVDVDACVAEKELRE------RQL 639

Human   387 GPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSD 451
            ..|..::..|..:.|| :||...:     |||  |..|:|..:|...:.:||.....|.:.:.:|
  Fly   640 EIYGRVDAKSFAIYKN-KPFRKTE-----LGV--ESRRRLKFDGLATLMQGRAKTQLVLVVVLTD 696

Human   452 VLLVTKPQRKADKAKVIRPP-----LMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPT 511
            .|.........:|.....|.     :.|:||:.:......|..:..::..........:...:|.
  Fly   697 CLCFLSENSGHNKYSFFTPEHKAGVVPLQKLLIREKAGTESRGIYIISSNPDFPEMYELKVQTPK 761

Human   512 DRAQWLEKTQQAQ--------AALQKLKAEEYVQ---QKRELLTLYRDQDRESPSTRPSTPSLE- 564
            |:..|::..:||.        ...:.|.|||.::   .|||.:...|.:|.|..........|:
  Fly   762 DKNTWIQTIRQAVLDCPATDIIEAEDLTAEEKLRIGVNKRETIEKMRQKDIEQALLLEEKLMLQF 826

Human   565 ---------------GSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSD-SGYGTLIPGT 613
                           .|..||......|.:....:....||.|....|.:...| |...:.|...
  Fly   827 NLLKEQQPFGDVAGTNSSCSAANFLAAFGSYKDLVSADCDTAELWRRVLNTVQDISQLASTIYSA 891

Human   614 PTGSRSP--LSRL--RQRALRRDPRL-----TFSTLELRDIPLRPH---PPDPQAPQRRSAPELP 666
            .||...|  ||.:  :|......|.|     ||:..:.:...|...   .|..|..:.:..|:
  Fly   892 ATGQPVPRTLSSVGEKQSEQYASPTLPKRAETFAGFDEKRGKLASKLVLTPRLQELEEKREPK-- 954

Human   667 EGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRAR---------------LRGQL------ 710
                .|.|...|.|          .|....|::..|..:               |:.||
  Fly   955 ----SGSSSVSEQP----------LENNYAVLQVTHHLQTLLCVISQQMTTINNLQLQLALYRES 1005

Human   711 --PSSPTHADSAGE--SPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAE 771
              .|:.||.|...|  :..:...||:......||.....|..|||:.:  ::::::.:::    |
  Fly  1006 PRSSAYTHKDQLEELRNLQDKQQEEKTAWQRQLKQQQEELAEMRAQQL--QLQKQIKAEQ----E 1064

Human   772 EPRDSRPRKLTRAQLQRMRGPHIIQLDTPL 801
            :.|..|.:...:.:|...:| .::...|||
  Fly  1065 DVRQQREQLYKKMELLSSQG-LLLSPSTPL 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHG6	NP_001371533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..91		7/30 (23%)
		RhoGEF	165..367	CDD:459876	47/228 (21%)
		PH_PLEKHG5_G6	424..522	CDD:270064	17/102 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..693		33/176 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..746		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..806		8/38 (21%)
cyst	NP_001260588.1	RhoGEF	447..627	CDD:214619	47/228 (21%)
		PH_ARHGEF2_18_like	671..774	CDD:275432	17/102 (17%)
		SMC_prok_B	935..>1073	CDD:274008	29/159 (18%)