Protein Alignment AVPR1A and AkhR

DIOPT Version :10

• Sequence 1: XP_054228380.1
• Gene: AVPR1A / 552
• HGNCID: 895
• Length: 421
• Species: Homo sapiens
• Sequence 2: NP_995639.1
• Gene: AkhR / 33942
• FlyBaseID: FBgn0025595
• Length: 455
• Species: Drosophila melanogaster
• Alignment Length: 356
• Identity: 103/356 - (28%)
• Similarity: 173/356 - (48%)
• Gaps: 55/356 - (15%)

Human    55 KLEIAVLAVTFAVAVLGNSSVL-LALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITY 118
            :|.|.|.::.|.::.:|||:|| |...|..|...|:.:.:.||::|||.|....:..::.|..|.
  Fly    39 RLSITVYSILFVISTIGNSTVLYLLTKRRLRGPLRIDIMLMHLAIADLMVTLLLMPMEIVWAWTV 103

Human   119 RFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV 183
            ::...|.:||::...:|||::.|:|::|.::.|||.|:..|||   :...|.|:|:|.||:.|.|
  Fly   104 QWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYFAILKPLK---RSYNRGRIMLACAWLGSVV 165

Human   184 LSTPQYFVFSMIEVNNVTKARDC--WATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNI 246
            .|.||.|:|.:.|...||....|  :.:|...:..:.|.......::..|:::...|||.|...|
  Fly   166 CSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSDFDEKLYQAASMCSMYAFPLIMFIYCYGAIYLEI 230

Human   247 WCNVRGKTASRQSKGAEQAGVA--FQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAP 309
            :         |:|:...:..:|  |::        |:...:||||.||:|||..||..:|:||.|
  Fly   231 Y---------RKSQRVLKDVIAERFRR--------SNDDVLSRAKKRTLKMTITIVIVFIICWTP 278

Human   310 FFIIQMWSVWDPMSVWTESE-----NPTI-TITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPC 368
            ::.|.||       .|.:..     ||.: ....:..|.|||.||.:|..:
  Fly   279 YYTISMW-------YWLDKHSAGKINPLLRKALFIFASTNSCMNPLVYGLY-------------- 322

Human   369 CQNMKEKFNKEDTDSMSRRQTFYSNNRSPTN 399
              |::.:.| .:..|::.|.|..||....:|
  Fly   323 --NIRGRMN-NNNPSVNNRHTSLSNRLDSSN 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AVPR1A	XP_054228380.1	7tmA_V1aR	55..362	CDD:320507	95/317 (30%)
		TM helix 1	56..82	CDD:320507	10/26 (38%)
		TM helix 2	89..116	CDD:320507	7/26 (27%)
		TM helix 3	127..157	CDD:320507	12/29 (41%)
		TM helix 4	169..190	CDD:320507	11/20 (55%)
		TM helix 5	216..245	CDD:320507	6/28 (21%)
		TM helix 6	287..317	CDD:320507	16/29 (55%)
		TM helix 7	330..355	CDD:320507	9/25 (36%)
		V1R_C	375..421	CDD:430355	7/25 (28%)
AkhR	NP_995639.1	7tmA_AKHR	39..328	CDD:320504	96/331 (29%)
		TM helix 1	40..66	CDD:320504	10/25 (40%)
		TM helix 2	74..101	CDD:320504	7/26 (27%)
		TM helix 3	112..142	CDD:320504	12/29 (41%)
		TM helix 4	151..172	CDD:320504	11/20 (55%)
		TM helix 5	200..229	CDD:320504	6/28 (21%)
		TM helix 6	256..286	CDD:320504	17/36 (47%)
		TM helix 7	298..323	CDD:320504	8/40 (20%)