Protein Alignment AVPR1A and CCAP-R

DIOPT Version :10

• Sequence 1: XP_054228380.1
• Gene: AVPR1A / 552
• HGNCID: 895
• Length: 421
• Species: Homo sapiens
• Sequence 2: NP_001368957.1
• Gene: CCAP-R / 2768688
• FlyBaseID: FBgn0039396
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 413
• Identity: 122/413 - (29%)
• Similarity: 190/413 - (46%)
• Gaps: 62/413 - (15%)

Human    18 SSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEE----LAKLEIAVLAVTFAVAVLGNSSVLLA 78
            ::|...|.||..:||.:          |.:..|..    ....:.|||.:.|.|.|||||:||..
  Fly    93 AAPSHDLETGGNSTSSD----------PGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFV 147

Human    79 LHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAY 143
            :.....:.|||:.||:.|:||||.|....||..:.|.||..:|..:..|:.::..||...::|.|
  Fly   148 MFINKNRKSRMNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTY 212

Human   144 MLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWA 208
            :||.|:.|||.|:.||: ...:..:|:|.::|.||::|.:.|.|   :..:.|...:.....||.
  Fly   213 VLVAMSIDRYDAITHPM-NFSKSWKRARHLVAGAWLISALFSLP---ILVLYEEKLIQGHPQCWI 273

Human   209 TFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGA-----EQAGVA 268
            ....|...:.|::.::..:|..|.:|:..||..|...||           :||:     |:|
  Fly   274 ELGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIW-----------AKGSIFVPTERA--- 324

Human   269 FQKGFLLAPC--VSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENP 331
               ||..||.  .||...|.|||::|||||..||..:|:||:|:.|..:..|:..:. .:::...
  Fly   325 ---GFGAAPARRASSRGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIP-HSQTNIA 385

Human   332 TITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFP-------CCQNMKEKFNK----------- 378
            ..|....|..|||..||.||..||..:.: .:..||       ||::.:....:
  Fly   386 IATFIQSLAPLNSAANPLIYCLFSSQVFR-TLSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLH 449

Human   379 EDTDSMSRRQTFYSNNRSPTNST 401
            ...|||....|..:.:|..||.|
  Fly   450 NSCDSMRTLTTSLTVSRRSTNKT 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AVPR1A	XP_054228380.1	7tmA_V1aR	55..362	CDD:320507	102/313 (33%)
		TM helix 1	56..82	CDD:320507	12/25 (48%)
		TM helix 2	89..116	CDD:320507	12/26 (46%)
		TM helix 3	127..157	CDD:320507	12/29 (41%)
		TM helix 4	169..190	CDD:320507	8/20 (40%)
		TM helix 5	216..245	CDD:320507	7/28 (25%)
		TM helix 6	287..317	CDD:320507	15/29 (52%)
		TM helix 7	330..355	CDD:320507	9/24 (38%)
		V1R_C	375..421	CDD:430355	8/38 (21%)
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	102/314 (32%)
		TM helix 1	125..151	CDD:320325	12/25 (48%)
		TM helix 2	158..185	CDD:320325	12/26 (46%)
		TM helix 3	196..226	CDD:320325	12/29 (41%)
		TM helix 4	237..258	CDD:320325	8/23 (35%)
		TM helix 5	281..310	CDD:320325	7/28 (25%)
		TM helix 6	342..372	CDD:320325	15/29 (52%)
		TM helix 7	384..409	CDD:320325	9/24 (38%)