Protein Alignment RNF220 and rnf220a

DIOPT Version :10

• Sequence 1: NP_001363415.1
• Gene: RNF220 / 55182
• HGNCID: 25552
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001430222.1
• Gene: rnf220a / 561654
• ZFINID: ZDB-GENE-060929-1006
• Length: 695
• Species: Danio rerio
• Alignment Length: 700
• Identity: 489/700 - (69%)
• Similarity: 533/700 - (76%)
• Gaps: 113/700 - (16%)

Human     1 MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHIPFTNG 65
            |||||||||||:||||||||||||||||||||||||||||||||||||||||||:||||:||.||
Zfish     1 MDLHRAAFKMESSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVEKDVHLPFNNG 65

Human    66 SYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFAS-TEDR 129
            ||||||||||||.||..|.||||||||||||.|||||||||:|||||||||||||||||| .|||
Zfish    66 SYTFASMYHRQGAVPPGFPNRDFPPSLLHLHHQFAPPNLDCSPISMLNHSGVGAFRPFASPPEDR 130

Human   130 E----SYQSAFTPAKRLKNCHDTE-SPHLRFSDADGKEYDF-GTQLPSSSPGSLK-VDDTGKKIF 187
            :    .||||||||||||.|.:.| |||||:|||:|||||| |.|:|||||.:|| |:|.|||||
Zfish   131 DGAGGGYQSAFTPAKRLKGCLEAEASPHLRYSDAEGKEYDFGGAQIPSSSPSALKAVEDAGKKIF 195

Human   188 AVSGLISDREASSSPEDRNDRCKKKAAALFDSQAPICPICQVLLRPSELQEHMEQELEQLAQLPS 252
            |||||:||||.|||||||.:||||| .:|:||||||||||||||||.|||||||||:|:|..:..
Zfish   196 AVSGLLSDRETSSSPEDRIERCKKK-VSLYDSQAPICPICQVLLRPGELQEHMEQEMERLTHMHI 259

Human   253 SKNSLLKDA-MAPGTPKSLLLSASIKREGESPTASPHSSATDDLHHSDRYQTFLRVRANRQTRLN 316
            |||...||. :|||||||||||..||||||||..||.||  |:.|||||||||||||||||||||
Zfish   260 SKNPSHKDINVAPGTPKSLLLSVHIKREGESPVVSPLSS--DEAHHSDRYQTFLRVRANRQTRLN 322

Human   317 -----------------------------------ARIGKMKRRKQDEGQVCPLCNRPLAGSEQE 346
                                               ||||||||||.::|||||||:.||||:|:|
Zfish   323 VDDLCWCRRYAKESFKSPPIPVPRGVPLAPCCLRHARIGKMKRRKPEDGQVCPLCSAPLAGTEEE 387

Human   347 MSRHVEHCLSKREGSCMAEDDAVDIEHENNNRFEEYEWCGQKRIRATTLLEGGFRGSGFIMCSGK 411
            ||||||.||.||||:  .|:|:.|:|.||..||||||||||||:||||||||||||:||.|||.|
Zfish   388 MSRHVEQCLFKREGA--TEEDSADVEGENGTRFEEYEWCGQKRVRATTLLEGGFRGTGFAMCSTK 450

Human   412 ENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFS 476
            |:.||||||||||||||||||.||||||:|||:||:.|||||||||||||||||.||.|||||||
Zfish   451 ESHDSDADLDVDGDDTLEYGKAQYTEADIIPCSGEDQGEAKEREALRGAVLNGGVPSNRITPEFS 515

Human   477 KWASDEMPSTSNGESSKQE-------AMQKTCKNSDIEKITEDSAVTTFEALKARVRELERQLSR 534
            |||||||||||||||||||       :.|:|||||:||||||||..||.||||||:||||:|:.|
Zfish   516 KWASDEMPSTSNGESSKQEPSSSSSSSTQRTCKNSEIEKITEDSTATTLEALKARIRELEKQILR 580

Human   535 GDRYKCLICM------------------------------------------------------- 544
            ||||||||||
Zfish   581 GDRYKCLICMRKPTQTGADGKIQAAERHGSAEALQLGVYCLYRGYVTGCSTATAGSSGIKKLLPL 645

Human   545 --DSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL 592
              |||:||||||||||||||||||||||.|||||||||||:||||||:||
Zfish   646 RRDSYTMPLTSIQCWHVHCEECWLRTLGNKKLCPQCNTITSPGDLRRVYL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF220	NP_001363415.1	RNF220	217..470	CDD:464946	197/288 (68%)
		RING-HC_RNF220	538..589	CDD:438225	47/107 (44%)
rnf220a	NP_001430222.1	None