DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNF220 and RNF220

DIOPT Version :10

Sequence 1:NP_001363415.1 Gene:RNF220 / 55182 HGNCID:25552 Length:592 Species:Homo sapiens
Sequence 2:NP_651088.1 Gene:RNF220 / 42690 FlyBaseID:FBgn0039013 Length:398 Species:Drosophila melanogaster


Alignment Length:408 Identity:146/408 - (35%)
Similarity:201/408 - (49%) Gaps:72/408 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   223 ICPICQVLLRPSELQEHMEQELEQLAQLPSSKNSLLKDAMAPGTPKSLLLSASIKREGESPTASP 287
            |||.|.|.::.|::.:|.:.|:|:|.. |.|       |:.|.||.|            ..|||.
  Fly    25 ICPTCDVKIKRSQVADHCQVEMERLHN-PIS-------AVTPPTPTS------------GATASE 69

Human   288 HSSATDDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQV-------------------- 332
            .|.:...  ....:..|.||:.|||.|...|..|..........|                    
  Fly    70 ESGSVSG--GRQPWSVFQRVQRNRQARQRQRTRKRPASPAPPATVNPTVAAAPPPAAATPSVAAA 132

Human   333 ------CPLCNRPLAGSEQEMSRHVEHCL--SKREGSCMAEDDAVDIEHENNNRFEEYEWCGQKR 389
                  ||:||...  .:..:..||.|||  |:|.|....|..:.: :.|::..:|||||.||||
  Fly   133 ESSQPTCPVCNHNF--PQSNIQEHVNHCLRQSRRNGQANGERHSSE-DSEDSEEYEEYEWAGQKR 194

Human   390 IRATTLLEGGFRGSGF---IMCSGKE--NPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEP- 448
            ||.:||::||:...|.   |..:|.:  ..|.|.||:||.|||..||..||.|.||||...|:. 
  Fly   195 IRVSTLVQGGYSALGLGQRIKYNGSQQAQDDEDEDLNVDEDDTHIYGPTQYGEGDVIPLVNEDTE 259

Human   449 ---GEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMP-STSNGESSKQEAMQKTCKNSDIEKI 509
               .||.....:|..:.:...|.    |..|..|:::.| ||||.|:........|.:::   :.
  Fly   260 GNVSEADVTSYVRRLISSSDGPK----PNHSSEATEQEPASTSNVEAPPASEEPSTSRST---RS 317

Human   510 TEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKL 574
            |..:.....|:|||::|..|:| ::| :||||||:|.|..|..|:.|||||||:|||:||||:||
  Fly   318 TSQNQQQIIESLKAKLRLYEKQ-AQG-KYKCLICIDDYKNPAISVSCWHVHCEQCWLQTLGARKL 380

Human   575 CPQCNTITAPGDLRRIYL 592
            |||||:||.|.|||||||
  Fly   381 CPQCNSITTPKDLRRIYL 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNF220NP_001363415.1 RNF220 217..470 CDD:464946 86/283 (30%)
RING-HC_RNF220 538..589 CDD:438225 36/50 (72%)
RNF220NP_651088.1 RNF220 22..281 CDD:464946 88/292 (30%)
RING-HC_RNF220 344..395 CDD:438225 37/51 (73%)

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