DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PPP2R1A and Pp2A-29B

DIOPT Version :9

Sequence 1:	NP_055040.2	Gene:	PPP2R1A / 5518	HGNCID:	9302	Length:	589	Species:	Homo sapiens
Sequence 2:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	439/585 - (75%)
Similarity:	499/585 - (85%)	Gaps:	2/585 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAADG--DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDED 63
            |||:|.  ||||||||||||||:||||||||||||||||||||||.|||||||:||||:||||||
  Fly     1 MAASDKSVDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDED 65

Human    64 EVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHF 128
            |||||||:|||.||:||||||:...|:|||||||||||||||||||||||.::.|||..|||.|.
  Fly    66 EVLLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHV 130

Human   129 VPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFA 193
            ||.::||..|||||||||||||||||||||:..||||||..||.||.|:|||||||||:||||||
  Fly   131 VPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFA 195

Human   194 KVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWR 258
            ||:|.:.:||::||.|..||.|:|||||||||||||:|||||||:|:|.||:|||||.|.|.|||
  Fly   196 KVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWR 260

Human   259 VRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIM 323
            ||||||:||.:||||||||||:.|||||||.|:||.|||||||.:.|||:||.||....:..:|:
  Fly   261 VRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIIL 325

Human   324 SQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNL 388
            |.|||.:::||||.|.|||||||||||||||:||...|:|.||||||.|||||||||||||||||
  Fly   326 SSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNL 390

Human   389 DCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVD 453
            ||||:||||:||||||||||||||||:|||||||||||||.||||||.||||:||..|||.||.|
  Fly   391 DCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLND 455

Human   454 HVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITT 518
            ||||||||||.|:|||||:||..||...|||.:|.||.:.|||||||.|||:|||:||||.||||
  Fly   456 HVYAIREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITT 520

Human   519 KHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 583
            |.:|||||.:|.||||||||||||:||||.|.|:.|.:.::|||.|:||..|.|||||:||.:|:
  Fly   521 KLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAI 585

Human 584 583
Fly 586 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPP2R1A	NP_055040.2	PP2A subunit B binding	8..399		299/390 (77%)
		HEAT repeat	13..37	CDD:293787	22/23 (96%)
		Polyoma small and medium T antigens Binding	47..321		202/273 (74%)
		HEAT repeat	51..78	CDD:293787	22/26 (85%)
		SV40 small T antigen binding	85..239		113/153 (74%)
		HEAT repeat	88..118	CDD:293787	24/29 (83%)
		HEAT repeat	127..152	CDD:293787	18/24 (75%)
		HEAT repeat	163..192	CDD:293787	22/28 (79%)
		HEAT	166..196	CDD:397231	23/29 (79%)
		HEAT	187..>462	CDD:224331	207/274 (76%)
		HEAT repeat	204..234	CDD:293787	21/29 (72%)
		HEAT repeat	245..269	CDD:293787	18/23 (78%)
		HEAT repeat	283..311	CDD:293787	20/27 (74%)
		HEAT repeat	325..355	CDD:293787	22/29 (76%)
		HEAT repeat	364..390	CDD:293787	23/25 (92%)
		PP2A subunit C binding	400..589		134/184 (73%)
		HEAT repeat	401..430	CDD:293787	27/28 (96%)
		HEAT repeat	442..468	CDD:293787	19/25 (76%)
		HEAT repeat	479..508	CDD:293787	17/28 (61%)
		HEAT repeat	518..544	CDD:293787	20/25 (80%)
		HEAT repeat	557..586	CDD:293787	15/27 (56%)
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	87/99 (88%)
		HEAT repeat	15..39	CDD:293787	22/23 (96%)
		HEAT repeat	53..80	CDD:293787	22/26 (85%)
		HEAT repeat	90..120	CDD:293787	24/29 (83%)
		HEAT repeat	129..154	CDD:293787	18/24 (75%)
		HEAT repeat	165..194	CDD:293787	22/28 (79%)
		HEAT_2	175..267	CDD:290374	68/91 (75%)
		HEAT_EZ	181..230	CDD:290247	35/48 (73%)
		HEAT repeat	206..232	CDD:293787	18/25 (72%)
		HEAT repeat	247..271	CDD:293787	18/23 (78%)
		HEAT repeat	285..313	CDD:293787	20/27 (74%)
		HEAT repeat	327..357	CDD:293787	22/29 (76%)
		HEAT repeat	366..392	CDD:293787	23/25 (92%)
		HEAT repeat	403..432	CDD:293787	27/28 (96%)
		HEAT repeat	444..470	CDD:293787	19/25 (76%)
		HEAT repeat	481..510	CDD:293787	17/28 (61%)
		HEAT repeat	520..546	CDD:293787	20/25 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1837
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68559
Inparanoid	1	1.050	862	1.000	Inparanoid score	I430
Isobase	1	0.950	-	0	Normalized mean entropy	S459
OMA	1	1.010	-	-		QHG54034
OrthoDB	1	1.010	-	-		D171719at33208
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		otm42005
orthoMCL	1	0.900	-	-		OOG6_101100
Panther	1	1.100	-	-	O	PTHR10648
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1
SonicParanoid	1	1.000	-	-		X1096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820