Protein Alignment PNPO and CG31473

DIOPT Version :9

• Sequence 1: NP_060599.1
• Gene: PNPO / 55163
• HGNCID: 30260
• Length: 261
• Species: Homo sapiens
• Sequence 2: NP_731188.1
• Gene: CG31473 / 318753
• FlyBaseID: FBgn0051473
• Length: 257
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 78/279 - (27%)
• Similarity: 114/279 - (40%)
• Gaps: 61/279 - (21%)

Human     2 TCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDRE--AFEETHLTSLDPVKQFAA 64
            |.|..|   :.||.|:.....:|             :.|..|..|  .:||.|:.       |..
  Fly    12 TLWSAG---SLGRFAQHMSNAAH-------------QVSCIGSEEQRVYEEPHVI-------FQN 53

Human    65 WFEEA-VQCPDIGEANAMCLATCTRDGKPSARMLLLKGFGKDGFRFFTNFESRKGKELDSNPFAS 128
            |...| .:.|.: .....|:||..:.|:|..|:..::.....|..|||...||:..|:.:||..|
  Fly    54 WLMAAQKEAPQV-RPRLACMATVDKSGEPVTRLTSIEEVNSHGITFFTTLGSRQAGEISANPHVS 117

Human   129 LVFYWEPLNRQVRVEGPVKKLPEEEAECYFHSRPKSSQIG-------AVVSHQSSVIPDREYLRK 186
            |.|.|.||.|.||:.|...:|.||:....|...|:..|:.       |....||.    ..:..:
  Fly   118 LHFNWAPLMRSVRIAGSAHQLTEEQVRDQFRRFPRHVQMSITHGPRYAAAEWQSR----SGFFAR 178

Human   187 KNEELEQLY--QDQEVPKPKSWGGYVLYPQVMEFWQ------GQTNRLHDRIVFRRGLPTGDSPL 243
            ..:.|....  |.:|:|.|.:||||:|.|.:.||..      |:|     |:.|||.|   :.|.
  Fly   179 IGQRLNTWLGKQPEEIPMPHNWGGYILTPSLYEFGMLSGEKAGRT-----RVRFRRCL---EMPR 235

Human   244 GPMTHRG-----EEDWLYE 257
            |  |..|     .:||:|:
  Fly   236 G--TRVGHVQAERQDWVYD 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPO	NP_060599.1	Pyridoxal 5'-phosphate binding. /evidence=ECO:0000250|UniProtKB:P0AFI7	42..45		1/2 (50%)
		pdxH	57..261	CDD:273138	65/222 (29%)
		Pyridoxal 5'-phosphate binding. /evidence=ECO:0000250|UniProtKB:P0AFI7	225..227		0/1 (0%)
CG31473	NP_731188.1	PRK05679	40..229	CDD:235555	59/205 (29%)
		Pyridox_oxidase	66..142	CDD:279568	27/75 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1192
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1337072at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10851
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.900