Protein Alignment ARHGEF10L and CG43102

DIOPT Version :9

• Sequence 1: NP_060595.3
• Gene: ARHGEF10L / 55160
• HGNCID: 25540
• Length: 1279
• Species: Homo sapiens
• Sequence 2: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Alignment Length: 1647
• Identity: 336/1647 - (20%)
• Similarity: 565/1647 - (34%)
• Gaps: 589/1647 - (35%)

Human     7 PPQP---------------AIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLA 56
            ||.|               |:...|||.:....|..|.|     |....:||.....|....:.:
  Fly  1084 PPIPHAACKISQTPSTLTTAVRSDLVPTISVSRSSEEGD-----ELAKIEDEPQVEVATTARNTS 1143

Human    57 PERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADA--AFSGARHSSWKR------KS 113
            .:|       |:......|.|             ::|.|...:  |.:..|||:.:|      ||
  Fly  1144 MDR-------HIREYSQDDLD-------------LANVDLRSSLEAIATPRHSTDERQRRHLDKS 1188

Human   114 SRR----IDRFTFPALEE--------DVI---YDDVPCESPDAHQPGAERNLLYEDAHRA----- 158
            ::|    ||...:.|..|        |:.   .:.:..|||:|:.|||.:  :|..:.::
  Fly  1189 TKRKGMYIDNADWQAPTEAPQRGLALDISVANLNAIKPESPEANTPGASQ--MYISSPQSSYSFE 1251

Human   159 --------GAPRQAEDLGWSS-----------SEFESYSEDSGEEAK------------PEVEVE 192
                    |:|      .|.|           |.|..:|.:..::|.            .:.|.:
  Fly  1252 LNTPELEKGSP------SWGSGGLVRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECD 1310

Human   193 PA-----KHRVSFQPKLSP---DLTRLKERYAR--------------------------TKRDIL 223
            .|     :.|::..|..|.   |..|..:|..|                          .:.|.|
  Fly  1311 RAIRERERERITSSPTPSSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRETDSL 1375

Human   224 ALR-------VGG-----RDMQELKHKYDCKMT-------------------------------Q 245
            .||       .||     |::.:..:....:.|                               |
  Fly  1376 HLRGSAPGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVPSHARAASTPSQLEHASKGISAATAQ 1440

Human   246 LMKAAKSGTKDGLEKTRMAVMRKVSFL------HRKDVLGDSEEE-------------------- 284
            :..:||:.::..|:.....:.|..|..      |.|.....|.|.
  Fly  1441 ISVSAKNLSQAELDDQVHHMKRAASEAPAPKSNHSKRSQSMSTERPSQHHHHHGHGHGHSHGHHH 1505

Human   285 ------DMGLLEVSVSD-------------------IKPPAPELGPMPEGLSPQQV--------- 315
                  |.|..:.:..:                   :||....|..:.:|.|...:
  Fly  1506 AGKRSLDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIA 1570

Human   316 -VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA-LSARKCQVVFFRVKEILHCHSMFQI 378
             .|.:::..|.::|.||||||:.::..|...|...|... :..|....:||.|.:||..|..|..
  Fly  1571 DTRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLS 1635

Human   379 ALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQV 443
            .|.||:.:||..:|:||.|:.:|||..||:||:.:|||...|.:.|:.....:|:|.:||:....
  Fly  1636 DLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAR 1700

Human   444 CSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLN-EQKRLA 507
            ....::||..|::||:|:||.:.||.|.::|:|...|||...||..|..:..:...:| :::.:.
  Fly  1701 EHKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIM 1765

Human   508 DQ------VAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLN 566
            :.      :.|::.:.:.::|       |.:.:||.||.:.::.    ..||..: |:|..||.|
  Fly  1766 ENGQREATLRELEGVIEGITD-------LIAPERQFLLFDLVSM----PSGQGAR-KDRGFFLFN 1818

Human   567 DMLVCANINFKPANHRGQLEISSLVPLGP--------KYVVKWNTALPQVQVVEVGQDGGTYDKD 623
            |:||..:|..:....|  ...||:.| |.        ||......:|..:::|:        .||
  Fly  1819 DLLVLTSIKKRSGTIR--KPNSSICP-GTVATTLDTNKYKFLTKISLDCLEIVK--------SKD 1872

Human   624 NVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVA 688
            ..:                       .|:..|::.|.:|...::|||.:..|:...:|.|. .|.
  Fly  1873 ENI-----------------------KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLE-DVI 1913

Human   689 QDWCLALQRLMRVKEEEIHSANKCRLRLLLP----------GKPDK------------------- 724
            ::....:||.:..::......|...|.:..|          .|.:|
  Fly  1914 RELHREVQRQLSERQTNDTQLNMLELTVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATL 1978

Human   725 SGRPISFMVVFITPNPLSKISWVNRLHLAKIGLR--------EENQPGWLC-------------- 767
            ...||.   .|:|..|:.|         .:.||:        .:|:..|:|
  Fly  1979 ERHPIP---EFLTSIPIRK---------TRAGLQFTCAAATLSDNRDVWVCNSDGYVGQVCIMSL 2031

Human   768 -PDEDKKS-----KAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYL 826
             |:.:..|     .|...|   ...:||:||.|                    |:.::|..|
  Fly  2032 HPEPNVTSCNGVCNARILC---VASVPAYSSAA--------------------SSRNSSSEQ--- 2070

Human   827 WVGGGQEGAGGQVEIFSLNRP---------------------------SPRTVKSFPLAAPVLCM 864
                 ..|:|||.|....:.|                           :|...|..|...||...
  Fly  2071 -----PAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKLTPTPTPVAGG 2130

Human   865 E----------------YIPELEEEAESRDESPTVA------------DPSATVH---------- 891
            |                .:...::|.|:...|..||            .|:.:.|
  Fly  2131 EPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQDSNPEEG 2195

Human   892 ----PTICLGLQDGSILLYSSVDT----GTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAA 948
                .|:.:|.:||.|.:|:|.|.    ..:..:...| .:..:|.|.:..|   ..|.:|.:..
  Fly  2196 ESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHS-AVYSILYLDNRVF---VSLANGDICV 2256

Human   949 YPRTSGGVLWDLESPPVCLTVG--PGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQD 1011
            |.| .|...|:..|.. ||::|  ..||..||::...:|.|....:.||:..||......:...|
  Fly  2257 YLR-DGATSWNTCSSH-CLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQISSD 2319

Human  1012 EAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG-----QKH----LC 1067
             :..:|:|..:.:.||::..:...|:.||:.|.:.:.|:|:|.....:|..     ::|    |.
  Fly  2320 -SKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHKAACLR 2383

Human  1068 VTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSL------NGHCGPVAFLA-VATSI 1125
            |||||.|:.|:|:||..||::.:|....|       ||.:::      :||.|.|.||. |.|:.
  Fly  2384 VTSLLCCKDLIWIGTSAGVLLTIPAQGYE-------KGAINIVPTGIPHGHTGHVRFLTFVETTG 2441

Human  1126 LAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSM 1190
            |        :..|.|.....|.....:.|           ..|:|
  Fly  2442 L--------EGAASGAGGGRDAGSSNSDE-----------YTKQG-------------------- 2467

Human  1191 REPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALG 1255
                     :::||:.                         :.|..:..|||||.||.:|.:: |
  Fly  2468 ---------SIKHSKS-------------------------KSETNNTLIISGGDGYEDFRNS-G 2497

Human  1256 SSGRQAPCGETDST--LLIWQV 1275
            ::......|..|||  |||||:
  Fly  2498 ANSLSEIAGREDSTNHLLIWQI 2519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF10L	NP_060595.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91		18/98 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..197		10/65 (15%)
		RhoGEF	317..501	CDD:238091	64/184 (35%)
		WD40 repeat	927..970	CDD:293791	12/42 (29%)
		WD40 repeat	978..1007	CDD:293791	7/28 (25%)
		WD40 repeat	1016..1046	CDD:293791	8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1163		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1186..1208		2/21 (10%)
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	63/181 (35%)
		PH-like	1750..>1889	CDD:302622	33/184 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850