Protein Alignment ARHGEF10L and CG43658

DIOPT Version :10

• Sequence 1: NP_060595.3
• Gene: ARHGEF10L / 55160
• HGNCID: 25540
• Length: 1279
• Species: Homo sapiens
• Sequence 2: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Alignment Length: 1110
• Identity: 333/1110 - (30%)
• Similarity: 510/1110 - (45%)
• Gaps: 222/1110 - (20%)

Human   301 PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFR 365
            |.|.|.|.|||.||:.||||:.:||.||.|||.:|:|::.||:.||.|..|..|:..|...:|..
  Fly   965 PMLPPAPAGLSQQQLKRRHIVAAIVHSENSYVATLQRLVNDYKKPLEECSPPVLNPVKIATLFHC 1029

Human   366 VKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLT 430
            :.:|||.|.:|:|:|:..|..||..|||||.||::|.|..:|::||.::|||::||.:.|.....
  Fly  1030 LPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLLEIYSGFINNFSAAMELAKMEEKR 1094

Human   431 KPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELET 495
            |.|..:|.|.:|:.:.||::.:||||||:||||||||.|||:||.||:||.||:||||||::||.
  Fly  1095 KSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDLLKYTPQGHHDRMSLQLALSQLEL 1159

Human   496 LAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSG-----------QRQLLLCETLTETVYG 549
            |||.|||.||.|:|....:::...:|...:...|..|.           .|.||..:.:|...:.
  Fly  1160 LAELLNESKREAEQYQAFKEMLGHISGTFNARSLSLSSVSVSDSAGGHRPRYLLREDNVTHMEFN 1224

Human   550 DRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVE-- 612
            ..|.::|.|:||:.||||.::|.::..|.::..|..|         |...||...:..|::|:
  Fly  1225 QAGFIVKCKQRRLLLLNDKVICVSVAPKQSHDFGATE---------KLTFKWMFPVNDVEIVDNS 1280

Human   613 ------------------------VGQDGGTYDKDNVLIQHSGA---------KKASASGQAQNK 644
                                    .|.:|..| .::.|..|.|.         ..:|.:.|..|
  Fly  1281 TSATLSRILTAGLNRGGSLKSNGSSGANGSPY-ANSTLPGHGGGVSGFSGFGDPHSSPAAQLTN- 1343

Human   645 VYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSA 709
               |...|..|:..|..|..|:.:|..|:|:|.|:|:.||....::....:|..::.|:||:...
  Fly  1344 ---GADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYKELNANTTRNVLNLIQGSIQRKDEEMAWV 1405

Human   710 NKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGW--------- 765
            :.|.|:|:  |: .|||:..:|  .|.|..|..|..|:..|.||::.|...|.|.|
  Fly  1406 DSCCLQLI--GR-HKSGKEETF--TFQTQTPAVKKEWITELRLAQLALDPNNSPAWERGGSHPQP 1465

Human   766 --------------------------LCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVH 804
                                      |...|..:.|.....|:....:|.:.|:.         .
  Fly  1466 AHHHPHHHPLQHPHAGAGDPRQTQEQLQLQEAVQQKQSRKMPLFVKAMPVYKSQH---------Q 1521

Human   805 SPVNCPLLGFSAVSTSLPQG----------YLWVGGGQEGAGGQVEIFSLNRPSP----RTVKSF 855
            :.|.|... :|..:.:...|          |||: ...:|....:.:.: ..|..    |...:|
  Fly  1522 TEVRCGCY-YSIANDTKQSGNARRRHKQLNYLWM-CSSDGTSSHITVLA-QHPQQAGNLREAGAF 1583

Human   856 PL-AAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVD-TGTQCLVS 918
            .| ...|..:|::..| ::.:||||      |::.:...:.||.....||:||:.: ...:.|.|
  Fly  1584 DLFETQVSALEFVKGL-DQLKSRDE------PASLLGDLVWLGTDSRKILIYSARNPEQEEQLGS 1641

Human   919 CRSPG-LQPVLCLRHSPFH---LLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGP----VR 975
            ...|| :|.:|      :|   :...|...|:..:.|.:.|| |.|..|.   |:..|.    |.
  Fly  1642 YSVPGAVQRIL------YHFDAVYVALSGATVLIFRRGNDGV-WQLRDPQ---TIRLGDTDLVVP 1696

Human   976 TLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFH 1040
            :||.:...::||||.||.|:.|...:.|:|||........|..|..:|.|:|::..:.|.:.|:|
  Fly  1697 SLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGATQQVNLMAHSGIGLWISLKNSTMLCLYH 1761

Human  1041 TETLEHLQEINIATRTTFLLPGQKH-------LCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGI 1098
            |||.:|||:||||: :.....|:|.       :.||:|:.|:|||||||:.|:.|.:|:|||||:
  Fly  1762 TETFKHLQDINIAS-SVLRHDGKKEQPLNNSSVYVTALMACKGLLWVGTNVGIAVTIPLPRLEGV 1825

Human  1099 PKITGKGMVSLNGHCGPVAFL--------------AVATSILAP---DILRSDQEEAEGPRAEED 1146
            |.|:|...:|.:.|.||:.||              .|..:.|.|   |.|:....:|: |:.:|
  Fly  1826 PIISGGINMSCHAHFGPITFLLPLIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAIDAD-PKIQE- 1888

Human  1147 KPDGQ-------AHEPMPDSHVGRELT----RKKGILLQYRLRS--TAHLPGPLLSMREPAPADG 1198
            ..||.       |.|.|..|:.|.:.|    |...:..|..|..  ||.:...|        |:.
  Fly  1889 LDDGAVVLRRDLAKEEMSSSNPGADSTASSPRSSKLDKQNSLDQSFTAKIRASL--------ANS 1945

Human  1199 AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGS---SGRQ 1260
            .|....       ...|||:...::.|       :.:.:.|..||..|    .||.||   ||..
  Fly  1946 PAFHRK-------RFRDDPNRMSKTLP-------RGLGAAAAGSGAGG----ASAAGSGTASGNT 1992

Human  1261 APCGE 1265
            :..||
  Fly  1993 SQHGE 1997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF10L	NP_060595.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..197
		RhoGEF	317..501	CDD:238091	93/183 (51%)
		PH_19	526..681	CDD:465965	44/200 (22%)
		WD40_2	789..1279	CDD:465964	147/541 (27%)
		WD40 repeat	927..970	CDD:293791	11/45 (24%)
		WD40 repeat	978..1007	CDD:293791	11/28 (39%)
		WD40 repeat	1016..1046	CDD:293791	11/29 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1163		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1186..1208		3/21 (14%)
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	82/168 (49%)
		PH_19	1210..1376	CDD:465965	42/179 (23%)
		WD40_2	1551..>1846	CDD:465964	100/314 (32%)