DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGEF10L and PsGEF

DIOPT Version :9

Sequence 1:NP_060595.3 Gene:ARHGEF10L / 55160 HGNCID:25540 Length:1279 Species:Homo sapiens
Sequence 2:NP_996333.4 Gene:PsGEF / 31224 FlyBaseID:FBgn0264598 Length:2777 Species:Drosophila melanogaster


Alignment Length:1521 Identity:264/1521 - (17%)
Similarity:444/1521 - (29%) Gaps:575/1521 - (37%)


- Green bases have known domain annotations that are detailed below.


Human     2 ASSNPPP-----QPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDT 61
            |.:.|||     ||            .::..:|...|.....|.|.::|                
  Fly   451 AQACPPPTSRHSQP------------KANAGQDQKQETEAAKDQDKQQD---------------- 487

Human    62 DPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALE 126
            |.|.....::.||...|.|...|:|     ||..|.                          ||.
  Fly   488 DSPAEMAAAVTVTPQKPVATGSGSG-----SNSAAM--------------------------ALN 521

Human   127 EDVI---YDDVPCESP---------------DAHQPGAERNLLYE--------DAHRAGAPRQAE 165
            ::||   .|.:..|.|               ..||..|:.||...        |.:......||:
  Fly   522 DEVISISIDSMGKEDPLLPQQPQQPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQ 586

Human   166 DLGWSSSEFESYSEDSG-----------EEAKPEV-------EVEPAKHRVSFQPKLSPDLTRLK 212
            ..|..||..::...::.           :...|..       .|...:.|..|  .::..|||.:
  Fly   587 ATGSQSSASKANESNANHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPF--TMTKRLTRTE 649

Human   213 E-------------RYARTKRDILALRVG-------------------GRDMQELKHKYDCKMT- 244
            |             |..:.:..:.|.|.|                   ..|:..|.......:| 
  Fly   650 ERGFGFSIVWTHPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTL 714

Human   245 QLMKAAKSG----TKDGLEKTRMAVMRKVSFLHRKDVLGDSEEED------------MGLLEVSV 293
            ::.:.:.:|    |...|.:..:.:..::.     ..:|...||.            |.|...:.
  Fly   715 EIFRRSGAGATTITSTDLGQNNVHISTRLG-----AAVGLGSEEHTLATTATGTTTVMSLQRTTS 774

Human   294 SDIKP-------PA-------------------PELGPMPEGLSPQQVVRRHILGSIVQSEGSYV 332
            :.|:|       ||                   |::....|.:.|....||..|..::..|.::.
  Fly   775 TRIQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISREQNFT 839

Human   333 ESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIA--LSSRVAEWDSTEKIGD 395
            .:|...:..:..||.|.: ..:|....:.:|..:.|:|      :||  :..::...|..::...
  Fly   840 AALHFGVDRFVQPLGERK-DLISPNDHRTLFQNIDELL------RIAEDILEQLCSSDQQDQEPQ 897

Human   396 LFVAS---FSK-SMVLDVYSDYVNNFTSA-MSIIKKACLTKPAFLEFLKRRQV--CSPDRVTLYG 453
            :..||   .|| :.:...|..|.|....| ..::.|:..|...|:.|:....|  ..|| :|:: 
  Fly   898 MNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAVPRKRPD-LTMF- 960

Human   454 LMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTK 518
             :.:|:|.|.:.:.|:|.:..|.   |.|        ||         |.|..:..:.|:|...:
  Fly   961 -IHRPLQHFREILKLMQLLAGNC---HVD--------TE---------EHKNFSTVINELQAAYR 1004

Human   519 SVSDRSSLNKLLTSGQRQLLL-----------CETLTETVYGDR-----------GQLIK----- 556
            .::..|.|.:.|..|:..|.|           |:..|..|.|.:           |:.:|     
  Fly  1005 EITVSSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPYWTL 1069

Human   557 -----------SKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQV 610
                       |::|.:|:..:.:..||:            :.|...:..|......|..|..::
  Fly  1070 LFSDIIVFAKVSRDRVLFITEEPIPIANV------------VDSCFHMRKKTTEFRLTVDPNGRL 1122

Human   611 VEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLIST 675
            .|  ...|....|.......||::.|        :.|..|.|  ||:.:.::| :..||.|:.:.
  Fly  1123 AE--SPTGYCAPDLTRTPKRGARRKS--------LILRAPSL--ELKAVWQNL-LQRQIFLVNAA 1174

Human   676 LHGT-----------------YQNLNMTVAQDWCLALQRL--MRVKEEE-----------IHSA- 709
            |..|                 ..::.:|.|....:.|..|  :.:|:::           :||| 
  Fly  1175 LGSTPLSSPLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQRTNNSHGHVHSAT 1239

Human   710 -------------------------------NKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSK 743
                                           .|||:.       :|:|.|.|        :.|..
  Fly  1240 GVATDRTADRSHGHNHGIHGGHVEQIELLIDEKCRIL-------NKTGTPKS--------SALHL 1289

Human   744 ISWV--------NRLHLAKIGLREEN-----QPGWLCPDEDKKSKAPFWCPILACCIPAFSSRAL 795
            .:|:        .:..||.|...:||     :......|.::..:..:|..      .....|..
  Fly  1290 ANWMKGQLDKQQQQARLAAIARSQENVSAEDEQLIFNSDSEQDERITYWTR------QQLEKRTK 1348

Human   796 SLQL----GALVHSP--VNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQV-EIFSLNRPSPRTVK 853
            .|.|    |.|...|  ....|.|...:|.|.... ::.....||....: :..|....|..||:
  Fly  1349 ELNLAKENGGLSARPNFGGKRLSGVEELSMSATSD-IYSTSEAEGVTSVISQSHSTTSDSQITVR 1412

Human   854 SFPLAAPVL--CMEYIPELEEEAESRDESPTVADP--------SATVHPTICLGLQDGSILLYSS 908
            |.|:....|  |...      ....:...|..|.|        |::....:|     .|:.:..|
  Fly  1413 SSPIVLDKLAVCRHC------HKNCQQSGPGGARPGGGGGVNNSSSTPVLLC-----NSLKVQHS 1466

Human   909 VDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGP 973
            ..:..:|   |:                |..|:...|..|.|:.|...           ..|.|.
  Fly  1467 QSSPNRC---CK----------------LSNGIAGATEMANPKNSNRT-----------GTGTGS 1501

Human   974 VRTLLS------LEDAVWASCGPRVT------VLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGV 1026
            |.::.|      |...|.||...|.|      |.:..|.:..||.....|::|.........:|.
  Fly  1502 VTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDSVGAMPNSSRSAGE 1566

Human  1027 WMAFSSGTSIRLFHTETLEHLQ-EINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLL 1090
            .....:|:.:|        ||. .:::::     ||             .|....|...|....|
  Fly  1567 GNPVITGSRLR--------HLDPPVSVSS-----LP-------------NGHCSAGVGGGSPKPL 1605

Human  1091 PVPR--------------------LEGIPKIT------------GKGMVSLNG------------ 1111
            |.||                    ::.|..||            |.|..|..|            
  Fly  1606 PPPRRTRVVAQMCQEPPRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPAKYA 1670

Human  1112 --HC--------------------------GP---------------VAFLAVATSILAPDILRS 1133
              ||                          .|               ::.:.:..:.|||.....
  Fly  1671 ACHCRCTPEDFTHAQLSPDKMEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQLAPAATLC 1735

Human  1134 DQEEAEGPRAEEDKPDGQAHEPMPDS 1159
            .||..  |:.|...|......|.|||
  Fly  1736 GQERI--PKEENSTPTIAVVPPTPDS 1759

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGEF10LNP_060595.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91 19/93 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 159..197 7/55 (13%)
RhoGEF 317..501 CDD:238091 41/192 (21%)
WD40 repeat 927..970 CDD:293791 6/42 (14%)
WD40 repeat 978..1007 CDD:293791 11/40 (28%)
WD40 repeat 1016..1046 CDD:293791 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1135..1163 9/25 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1186..1208
PsGEFNP_996333.4 DUF4799 <102..209 CDD:292674
C2 286..>381 CDD:278593
PDZ_signaling 644..716 CDD:238492 11/71 (15%)
RhoGEF 831..1000 CDD:295373 41/198 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3522
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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