DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIGN and figl-1

DIOPT Version :9

Sequence 1:	XP_011509691.1	Gene:	FIGN / 55137	HGNCID:	13285	Length:	785	Species:	Homo sapiens
Sequence 2:	NP_504197.1	Gene:	figl-1 / 178829	WormBaseID:	WBGene00017981	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	479	Identity:	158/479 - (32%)
Similarity:	252/479 - (52%)	Gaps:	61/479 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   313 PT----TVPGYTYQGHGLT----PIAPSALTNSSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRS 369
            ||    |.|.:..|.|..|    .:|.:.....:.:..|.:|   |.|..:.:.|.:::....:.
Worm   161 PTNARRTDPNFIRQMHENTLKGIEVASNPHFKKTRAPTKNRA---AIQNTLGTLYPSFTTAAGQD 222

Human   370 TQSPMYRMPDNSISNTNRGNGFDRSAETSSLAFKPTKQLMSSEQQRKFSSQSSRALTPPSYSTAK 434
            .|:..:::|            .||.:.:.|:                    .|.|..||:....
Worm   223 PQNSKFQVP------------LDRQSSSQSI--------------------GSLAGIPPARRAP- 254

Human   435 NSLGSRSSESFGKYTSPVMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVT 499
             .:..|.|....:....:.:|.|.:..::       .||||        :..||:.|.::|.|:.
Worm   255 -DIPKRCSNPLIRKAMGMDTEGGGKDEKM-------SGLRA--------EPTLKHFDENIISLIE 303

Human   500 NEIITQGPPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRC 564
            :||::....:.|.|:|||:..|..::|.|:.|..|.|.|:|:.|.|:.:|||||.|||||::|||
Worm   304 SEIMSVNNEIGWADVAGLEGAKKALREIVVLPFKRPDVFTGIRAPPKGVLLFGPPGTGKTMIGRC 368

Human   565 IASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVNEEHSPVS 629
            :|||..||||.|:.|.|.:||:||.||::.|.|.|||.:.|||||:.:||.||||:...||....
Worm   369 VASQCKATFFNISASSLTSKWVGEGEKLVRALFSVARLKLPSVIFIDEIDSLLSSRSESEHESSR 433

Human   630 RMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLSQ 694
            |::||||:|||.|.|:.:::::|:.||::|:|:||:.||.|.|||.|.||:..:|.||:..||..
Worm   434 RIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEAARRRFQKRLYIALPEPESRTQIVQNLLVG 498

Human   695 HNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLHAMPATDLSAIMPSQLRPVTYQDFENAF 759
            ..:.:.:.....:.:.|:|:||.|:..||.||.:||:..: ..|:..|....:|.||..||..|.
Worm   499 TRHDITNHNLERIRELTDGYSGADMRQLCTEAAMGPIRDI-GDDIETIDKDDIRAVTVMDFAEAA 562

Human   760 CKIQPSISQKELDMYVEWNKMFGC 783
            ..::|::...:||.|..|:|.|||
Worm   563 RVVRPTVDDSQLDAYAAWDKKFGC 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIGN	XP_011509691.1	AAA	545..680	CDD:214640	73/134 (54%)
		AAA	548..678	CDD:278434	71/129 (55%)
		Vps4_C	<749..782	CDD:286426	11/32 (34%)
figl-1	NP_504197.1	P-loop_NTPase	315..>371	CDD:304359	28/55 (51%)
		AAA	348..484	CDD:214640	73/135 (54%)
		AAA	352..480	CDD:278434	70/127 (55%)
		Vps4_C	<545..585	CDD:286426	13/39 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161469316
Domainoid	1	1.000	45	1.000	Domainoid score	I9076
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	372	1.000	Inparanoid score	I1372
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15365
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23074
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900