Protein Alignment WRAP53 and Wrap53

DIOPT Version :10

• Sequence 1: NP_060551.2
• Gene: WRAP53 / 55135
• HGNCID: 25522
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_659073.1
• Gene: Wrap53 / 216853
• MGIID: 2384933
• Length: 532
• Species: Mus musculus
• Alignment Length: 543
• Identity: 424/543 - (78%)
• Similarity: 452/543 - (83%)
• Gaps: 18/543 - (3%)

Human     1 MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAGSAVSQ 65
            |||.|.:.||||..|.|..|||.   |..||..||.|.|.:|||....|.|:|:.||||...|||
Mouse     1 MKTSEERLLAPDSLPPDLAPAPV---PQGSPAEKNTDFEPVPPPCGGDDQPQLATDPVASLVVSQ 62

Human    66 ELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANGPELGSGKAME 130
            ||::||    |.|||.||.:.|||||.||||::||:.|||.         ||.|.|||.||:|.|
Mouse    63 ELQQGD----SVPLEVEFNTSSELSPGIEEQDVSEHASLPG---------EETNLPELESGEATE 114

Human   131 DTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRI 195
            ..|.|.|..|||||.|.|||||:||:||||||||||:.|||||||||||||||||||||||:|||
Mouse   115 GVSEERAEVDEGDTFWTYSFSQVPRYLSGSWSEFSTRSENFLKGCKWAPDGSCILTNSADNVLRI 179

Human   196 YNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAF 260
            ||||||||.|.|||:|||||||||||||||||||||||||||.||||||||||||||||||||||
Mouse   180 YNLPPELYSEQEQVDYAEMVPVLRMVEGDTIYDYCWYSLMSSTQPDTSYVASSSRENPIHIWDAF 244

Human   261 TGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQS 325
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Mouse   245 TGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQS 309

Human   326 GIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDA 390
            ||||||||||:|||||||||||::|||||||||||||||||||||||||||||||.|||||||||
Mouse   310 GIISCIAFSPSQPLYACGSYGRTIGLYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDA 374

Human   391 ELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGP-GNDGKPEPV 454
            |||||||||.|:.||||.|||||||||||||||:|||||||:|||.|||||..|. .:|.|.|||
Mouse   375 ELLCWDLRQPGHLLWSLSREVTTNQRIYFDLDPSGQFLVSGNTSGVVSVWDISGALSDDSKLEPV 439

Human   455 LSFLPQKDCTNGVSLHPSLPLLATASGQRVFPEPTESGDEGE-ELGLPLLSTRHVHLECRLQLWW 518
            ::|||||||||||||||:|||||||||||||||||.|||||| ||.|||||..|.|.||:|||||
Mouse   440 VTFLPQKDCTNGVSLHPTLPLLATASGQRVFPEPTNSGDEGELELELPLLSLCHAHPECQLQLWW 504

Human   519 CGGAPDSSIPDDHQGEKGQGGTE 541
            |||.||.|.|.|.|.||||..||
Mouse   505 CGGGPDPSSPVDDQDEKGQRRTE 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WRAP53	NP_060551.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..142		71/140 (51%)
		WD 1. /evidence=ECO:0000255	167..206		34/38 (89%)
		WD40 repeat	175..223	CDD:293791	43/47 (91%)
		WD40	<177..481	CDD:441893	276/304 (91%)
		WD 2. /evidence=ECO:0000255	222..267		43/44 (98%)
		WD40 repeat	227..273	CDD:293791	44/45 (98%)
		WD 3. /evidence=ECO:0000255	272..313		39/40 (98%)
		WD40 repeat	280..319	CDD:293791	37/38 (97%)
		WD 4. /evidence=ECO:0000255	323..364		37/40 (93%)
		WD40 repeat	329..364	CDD:293791	31/34 (91%)
		WD 5. /evidence=ECO:0000255	365..405		35/39 (90%)
		WD40 repeat	370..410	CDD:293791	34/39 (87%)
		WD 6. /evidence=ECO:0000255	411..450		30/39 (77%)
		WD40 repeat	418..456	CDD:293791	27/38 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..548		10/16 (63%)
Wrap53	NP_659073.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		26/54 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..122		26/50 (52%)
		WD 1. /evidence=ECO:0000255	151..190		34/38 (89%)
		WD40 repeat	159..204	CDD:293791	40/44 (91%)
		WD40	<161..466	CDD:441893	276/304 (91%)
		WD 2. /evidence=ECO:0000255	206..251		43/44 (98%)
		WD40 repeat	211..257	CDD:293791	44/45 (98%)
		WD 3. /evidence=ECO:0000255	256..297		39/40 (98%)
		WD40 repeat	264..303	CDD:293791	37/38 (97%)
		WD 4. /evidence=ECO:0000255	307..348		37/40 (93%)
		WD40 repeat	313..348	CDD:293791	31/34 (91%)
		WD 5. /evidence=ECO:0000255	349..389		35/39 (90%)
		WD40 repeat	354..394	CDD:293791	34/39 (87%)
		WD 6. /evidence=ECO:0000255	395..434		29/38 (76%)
		WD40 repeat	402..442	CDD:293791	27/39 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..532		11/18 (61%)