Protein Alignment SRBD1 and SPT6

DIOPT Version :9

• Sequence 1: NP_060549.4
• Gene: SRBD1 / 55133
• HGNCID: 25521
• Length: 995
• Species: Homo sapiens
• Sequence 2: NP_011631.1
• Gene: SPT6 / 853011
• SGDID: S000003348
• Length: 1451
• Species: Saccharomyces cerevisiae
• Alignment Length: 1117
• Identity: 207/1117 - (18%)
• Similarity: 389/1117 - (34%)
• Gaps: 355/1117 - (31%)

Human    19 DEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISDGSEVVVV 83
            ||...|.|....|:|||:.......:||:.|.:....|.:.......::.:......||.:.
Yeast   194 DELDDFIEDDEFSDEDDETRQRRIQEKKLLREQSIKQPTQITGLSSDKIDEMYDIFGDGHDY--- 255

Human    84 KEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRTKKLKVE-------EETSK 141
                       |.|||....:|:.......|: :::...:...::.||| |:.       |:..|
Yeast   256 -----------DWALEIENEELENGNDNNEAE-EEEIDEETGAIKSTKK-KISLQDIYDLEDLKK 307

Human   142 ASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPVKFP----ANAN 202
            ....||:                                :|..||:...:.|.::..    .|.:
Yeast   308 NLMTEGD--------------------------------MKIRKTDIPERYQELRAGITDYGNMS 340

Human   203 STKEEVEMNWDMVQVLSERTNIE------------PWVCANIIRLFNDDN-TIPFIIRYRKELIN 254
            |..:|:|.||     ::|:.:::            .....|.|:....:| .:|||..||:..|:
Yeast   341 SEDQELERNW-----IAEKISVDKNFDANYDLTEFKEAIGNAIKFITKENLEVPFIYAYRRNYIS 400

Human   255 NLDADSLREVQQTLEELRAVAKKVHSTIQK---------------------IKKEGKMSECLLKA 298
            :.:.|.....:..|.::.::..:.||.:.|                     .|.:...|...|.:
Yeast   401 SREKDGFLLTEDDLWDIVSLDIEFHSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNTASIAELNS 465

Human   299 MLNCKTFEELEH--------VSAPYKTGSKGTK------------AQRARQLGLEGAARALLEKP 343
            :.:...:.|.::        ::...|||.|..|            .|....:|:..      |..
Yeast   466 LQDIYDYLEFKYANEINEMFINHTGKTGKKHLKNSSYEKFKASPLYQAVSDIGISA------EDV 524

Human   344 GE-LSLLSYIRPDV-----KGLSTLQ--------DIEI----------GVQHILADMIAKDKDTL 384
            || :|....|.|.|     |.:..::        |:::          .||...:..::|:....
Yeast   525 GENISSQHQIHPPVDHPSSKPVEVIESILNANSGDLQVFTSNTKLAIDTVQKYYSLELSKNTKIR 589

Human   385 DFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQ--HFSCNIRNIHHHQ----ILAINRGE 443
            :.:|:...|.:      ||.|......:|::.|..||:  .::.|...:|..:    .|.:...|
Yeast   590 EKVRSDFSKYY------LADVVLTAKGKKEIQKGSLYEDIKYAINRTPMHFRRDPDVFLKMVEAE 648

Human   444 NLKVLTVKVNISD----------------GVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDS 492
            :|.:|:||:::|.                ...|....|   |.:|          |:.:|...|.
Yeast   649 SLNLLSVKLHMSSQAQYIEHLFQIALETTNTSDIAIEW---NNFR----------KLAFNQAMDK 700

Human   493 FKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLMGV-DPGYKHGCKLAIIS 556
                |:..:.:|.:..||.:.:|    :..:.:|...:|.......:..| ||      |:
Yeast   701 ----IFQDISQEVKDNLTKNCQK----LVAKTVRHKFMTKLDQAPFIPNVRDP------KI---- 747

Human   557 PTSQILHTDVVYLHCGQGFREAEKIKTLLLN--------------------------------FN 589
                   ..::.|.||||...|:.|..:.:|                                .:
Yeast   748 -------PKILSLTCGQGRFGADAIIAVYVNRKGDFIRDYKIVDNPFDKTNPEKFEDTLDNIIQS 805

Human   590 CSTVVIGNGTACRETEAYFADL--------IMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMP 646
            |....||......:|:.::..|        |:.:....:.::|  |.:..|..|..|..|.:|.|
Yeast   806 CQPNAIGINGPNPKTQKFYKRLQEVLHKKQIVDSRGHTIPIIY--VEDEVAIRYQNSERAAQEFP 868

Human   647 GLDPNLRSAVSIARRVQDPL---AELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGV 708
            ...|.::..:::||.:..||   |.|...|.:.:.:..:|:.:|...|...|::...:.|:.|.|
Yeast   869 NKPPLVKYCIALARYMHSPLLEYANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVSV 933

Human   709 DINICSE-----VLLRHIAGLNANRAKNIIEWREK-NGPFINREQLKKVKGLGPKSFQQCAGFIR 767
            ::|..::     ..|::|:|....:|.:.::..:: |.|.:.|:||.....|....|...|||:.
Yeast   934 EVNKATDNNYYASALKYISGFGKRKAIDFLQSLQRLNEPLLARQQLITHNILHKTIFMNSAGFLY 998

Human   768 INQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPES 832
            |:                               .|||:.|.:.       |:.:.||.|.||||.
Yeast   999 IS-------------------------------WNEKRQKYED-------LEHDQLDSTRIHPED 1025

Human   833 YDIAMRFLSSIGGTLYE---VGKPEMQQKINSF-------------LEKEGMEKIAERLQ----- 876
            |.:|.:..:.  ...|:   :.:.|.|..::.|             ||...:|..||.|:
Yeast  1026 YHLATKVAAD--ALEYDPDTIAEKEEQGTMSEFIELLREDPDRRAKLESLNLESYAEELEKNTGL 1088

Human   877 ---TTVHTLQV-IIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVD 937
               ..::|:.: ::||..     :.|.||..         |:..:|...|||:.|. |.|
Yeast  1089 RKLNNLNTIVLELLDGFE-----ELRNDFHP---------LQGDEIFQSLTGESEK-TFF----- 1133

Human   938 IGVGKSGLIPIR 949
                |..:||:|
Yeast  1134 ----KGSIIPVR 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..81		12/57 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..165		8/51 (16%)
		Tex	208..991	CDD:225094	172/917 (19%)
		Tex_N	219..414	CDD:286460	43/272 (16%)
		Tex_YqgF	538..663	CDD:293526	29/165 (18%)
		HHH_3	705..767	CDD:289597	17/67 (25%)
		S1_Tex	919..990	CDD:240190	10/31 (32%)
SPT6	NP_011631.1	SPT6_acidic	28..128	CDD:405337
		Tex	346..1277	CDD:225094	172/917 (19%)
		SH2_2	1232..1436	CDD:405338

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900