DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRBD1 and Srbd1

DIOPT Version :9

Sequence 1:	NP_060549.4	Gene:	SRBD1 / 55133	HGNCID:	25521	Length:	995	Species:	Homo sapiens
Sequence 2:	XP_011245030.1	Gene:	Srbd1 / 78586	MGIID:	1925836	Length:	995	Species:	Mus musculus

Alignment Length:	1009	Identity:	814/1009 - (80%)
Similarity:	891/1009 - (88%)	Gaps:	28/1009 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMP 65
            |.||.:|.|:|.::...|||.|.||||||.||||:||||.|||||||||:|:||..|.||.|:.|
Mouse     1 MPSLRKRVKIQAENAEPKDECSFFSELSSGSEEDNKEDSIWEPQKKVPRNRRQPASKGSKRKQGP 65

Human    66 RVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRT 130
            |.||::.|:.|.|:.|.|||||||.|||.|..||::.:||.|.:|||||..|||   :| ..|..
Mouse    66 RAKKSSQQVDDESKDVAVKEELNSPVAIVDADLEEKSHKLQTTKTLKTAAKKQK---KP-VPRAK 126

Human   131 KKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPV 195
            |:|||:||||:||.|||..::.||||||.. |..|||||::|.||||||.:|:|:||:.|||:|.
Mouse   127 KRLKVDEETSQASPLEGGGSNVETPSTSAC-GNVCKKEESEDSFTFGQSPVKRIRTESCPQGRPA 190

Human   196 KFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADS 260
            :.|...:..|||||||||:|||||||||||||||||||||||||||||||:|||||||||||||.
Mouse   191 RVPDGVSDIKEEVEMNWDVVQVLSERTNIEPWVCANIIRLFNDDNTIPFIVRYRKELINNLDADF 255

Human   261 LREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQ 325
            ||||:|||:|||.|||||||.|||||||||||||||:|:|||||||||||||||||.||||||||
Mouse   256 LREVRQTLDELRDVAKKVHSRIQKIKKEGKMSECLLQALLNCKTFEELEHVSAPYKMGSKGTKAQ 320

Human   326 RARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKDTLDFIRNL 390
            ||:||||||||..|||.||:|:|||||:|||||||.|.|||.|||||||||||||||||||||.|
Mouse   321 RAKQLGLEGAAWTLLENPGQLNLLSYIKPDVKGLSELNDIETGVQHILADMIAKDKDTLDFIRGL 385

Human   391 CQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTVKVNIS 455
            |:.|::|||||||||||||||||:||||.|||:||||||.||||||||||||||||:||||||||
Mouse   386 CKHRYICIQSSLAKVSSKKVNEKEVDKFQLYQNFSCNIRTIHHHQILAINRGENLKILTVKVNIS 450

Human   456 DGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMM 520
            ||||:||||||||||||||.||||||||||:|||:|||||||.|||||||||||||||||:||||
Mouse   451 DGVKNEFCRWCIQNRWRPRGFARPELMKILHNSLDDSFKRLIVPLLCREFRAKLTSDAEKQSVMM 515

Human   521 FGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLL 585
            ||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
Mouse   516 FGQNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLL 580

Human   586 LNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDP 650
            |:|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   581 LHFNCRTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDP 645

Human   651 NLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSE 715
            |||||||||||||||||||||.:||||||||||||||||||||||||||||||||||||||||||
Mouse   646 NLRSAVSIARRVQDPLAELVKFDPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSE 710

Human   716 VLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQ 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||.
Mouse   711 VLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFVRINQDYIRTFCSQH 775

Human   781 TETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMR------- 838
            |::|||.|..|:       |||||.||||:|  .:..|.|||||||||||||||||:.
Mouse   776 TDSSGQSQETAM-------VTNEKLGKKKNK--ADATLIPNPLDQTCIHPESYDIAVSKRDTNFW 831

Human   839 -------FLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFD 896
                   |||.||||:.|:||||||||||..|.|||:|:.|||||||||||||||||||||::||
Mouse   832 SLYILYWFLSFIGGTMCEIGKPEMQQKINVSLGKEGIEETAERLQTTVHTLQVIIDGLSQPKTFD 896

Human   897 FRTDFDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKK 961
            .||||||||||||||||||||:|||||||||||||||:||||||||:||||||.:|||||||||:
Mouse   897 IRTDFDKPDFKRSIVCLEDLQVGTVLTGKVENATLFGVFVDIGVGKAGLIPIRFITEAKLSKTKR 961

Human   962 RRSLGLGPGERVEVQVLNIDIPRSRITLDLIRVL 995
            ||||||||||:|||:|||:|||||||:|||:|||
Mouse   962 RRSLGLGPGEKVEVKVLNVDIPRSRISLDLLRVL 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..81		37/57 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..165		22/44 (50%)
		Tex	208..991	CDD:225094	691/796 (87%)
		Tex_N	219..414	CDD:286460	170/194 (88%)
		Tex_YqgF	538..663	CDD:293526	121/124 (98%)
		HHH_3	705..767	CDD:289597	61/61 (100%)
		S1_Tex	919..990	CDD:240190	61/70 (87%)
Srbd1	XP_011245030.1	TFIIF_alpha	<9..186	CDD:310411	106/181 (59%)
Srbd1	XP_011245030.1	Tex	205..992	CDD:225094	690/795 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83966878
Domainoid	1	1.000	318	1.000	Domainoid score	I15226
eggNOG	1	0.900	-	-		E1_COG2183
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	1604	1.000	Inparanoid score	I2601
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D56990at2759
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto114080
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4297
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300