DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRBD1 and CG31156

DIOPT Version :9

Sequence 1:	NP_060549.4	Gene:	SRBD1 / 55133	HGNCID:	25521	Length:	995	Species:	Homo sapiens
Sequence 2:	NP_651070.3	Gene:	CG31156 / 42669	FlyBaseID:	FBgn0051156	Length:	948	Species:	Drosophila melanogaster

Alignment Length:	999	Identity:	343/999 - (34%)
Similarity:	532/999 - (53%)	Gaps:	130/999 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    60 KPKRMPRVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKL----DTVQTLKTAK----T 116
            :|:|....||...:|||..      ||:|.: |..|...|:.|:::    ...||:.|.:    |
  Fly     4 RPRRAASTKKIVIEISDSD------EEVNLT-ADDDYRPEETKSRIIDRAADAQTVVTKRQRFPT 61

Human   117 KQKCAAQPHTVRRTK--KLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDD------- 172
            .:|.||:....::.:  |.|.:|......| ..||...:|||||....|....|.|.:
  Fly    62 SKKTAAEGPAPKKKRGDKEKADENACPNEN-NPESVVQDTPSTSNQRNGAVGTEHNSEAPAPKRK 125

Human   173 ----DFTFGQSALKKIKTETYPQ----------GQPVKFPANANSTKE--------EVEMNWDMV 215
                |    :..||....||.|:          .||....|:::..|.        |....|::.
  Fly   126 RARKD----KEDLKTAANETNPEKGDVVPSTAVTQPNDIVASSSHNKSSTGRSSFWERRKVWNID 186

Human   216 QVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHS 280
            ::|:|..:|:|....||::||.|:||||||.|||::|::::..|.||:::.|..|:..:.|:..:
  Fly   187 ELLAETESIQPQAARNIVKLFEDENTIPFICRYRRDLVDHIAPDRLRDIRNTYTEIVDLRKRAEN 251

Human   281 TIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALL--EKP 343
            .|.|:::|..|:..:.:.::..|:.||||.:.||||..||||.|:||:.|||:..|..||  ..|
  Fly   252 IIGKLQRENIMTPEIREELMCAKSNEELEFLYAPYKPASKGTLAERAKALGLQVYADCLLYGSAP 316

Human   344 GELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKDTLDFIRNLCQKRHVCIQ--------- 399
             :::|...:....:.|:|...:..|:..|:...|:|:.:.|:.||.|.....|.::
  Fly   317 -KVNLSEIVDRRNEALATEALVMSGICQIIIHNISKNTNVLEEIRRLQNVHRVFLKCSKTKEAKS 380

Human   400 ---SSLAKVSSKKVNEKDVD------KFLLYQHFSCNIRNIHHHQILAINRGENLKVLTVKVNIS 455
               ||.:|.||.|.:.::.|      ||..|.:|..:::.|..:|:|||||||..|.|:||:..:
  Fly   381 SKSSSSSKASSSKGSNQNADKKLDSSKFENYFNFQGDVKTIKPYQMLAINRGEKHKWLSVKIETN 445

Human   456 DGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMM 520
            |.:|.:..|: |.:::..:....|...::...||.:.:.:.:.||:||:.||.|.....|.::.:
  Fly   446 DYLKRDLMRY-ITDQYMNQGLQYPLRREVFTKSLEECYAKKLQPLMCRQIRAALKEKGTKAAIDV 509

Human   521 FGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREA--EKIKT 583
            |.:||:||||.||:.|..::|:|||:.:|||||:||.|:.:|:|.|:|.|.....:.|  :|:..
  Fly   510 FAKNLKQLLLISPLKGERILGIDPGFINGCKLALISETADVLYTGVIYPHGAMSNKRAAEQKLVQ 574

Human   584 LLLNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGL 648
            ||.:.||..:.:||||||||||.:...:..........:.|.||:|.||||||.|..|.||.|.:
  Fly   575 LLSDHNCKIIGLGNGTACRETEHWLTGMFHAGVLDSRIIRYSIVNENGASIYSCSNVAAKEFPKM 639

Human   649 DPNLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINIC 713
            |.|.|||||||||:.|||:|.|||||:|:|||||||||.:.:|.|:|:.||.||||:||||:|..
  Fly   640 DTNERSAVSIARRLNDPLSEYVKIEPRHLGVGMYQHDVPEKILTASLNDVVSECVSYVGVDLNTA 704

Human   714 SEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCS 778
            |..:|:|||||:..:|:.|||.|.:.|||..|:.|..|:.:|.|||.|||||:||
  Fly   705 SLSVLKHIAGLSEKKAEKIIEHRTQKGPFKTRKDLLSVRSIGEKSFVQCAGFVRI---------- 759

Human   779 QQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSI 843
            :.....||:|                                ||||.|.:|||||::....:...
  Fly   760 EPRSVGGQLQ--------------------------------NPLDCTWVHPESYNVVESIVGEC 792

Human   844 GGTLYEVGKPEMQQKINSFLEKE-GMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDK-PDF 906
            ...|.:|||......|..|...: .:::||::.:..:..|:.::..|.:....|:|.|.|| |.|
  Fly   793 DLKLSDVGKAAFIASIKQFASSQPNLDRIAKQHKLPMERLEFLLVALQRELLQDYRADLDKRPLF 857

Human   907 KRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGE 971
            |:.:..|:||.:|.|:||.|.|.|.||.|||:||.::|||...|:..::||           .|:
  Fly   858 KQGLTRLDDLSMGEVVTGAVTNVTQFGAFVDVGVERNGLIHNSNMNNSQLS-----------VGD 911

Human   972 RVEVQVLNIDIPRSRITLDLIRVL 995
            |:...|:.:|:.|.::.|.|..:|
  Fly   912 RIVASVVKVDLKRRQLELRLENML 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..81		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..165		14/46 (30%)
		Tex	208..991	CDD:225094	295/806 (37%)
		Tex_N	219..414	CDD:286460	69/208 (33%)
		Tex_YqgF	538..663	CDD:293526	59/126 (47%)
		HHH_3	705..767	CDD:289597	32/61 (52%)
		S1_Tex	919..990	CDD:240190	25/70 (36%)
CG31156	NP_651070.3	Tex	184..931	CDD:225094	294/801 (37%)
		Tex_N	190..362	CDD:286460	61/172 (35%)
		Tex_YqgF	527..653	CDD:293526	58/125 (46%)
		HHH_3	697..758	CDD:289597	32/60 (53%)
		S1_like	870..930	CDD:299122	25/70 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156860
Domainoid	1	1.000	113	1.000	Domainoid score	I6186
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1297
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D321814at33208
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto88473
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4297
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800