DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRBD1 and Srbd1

DIOPT Version :9

Sequence 1:	NP_060549.4	Gene:	SRBD1 / 55133	HGNCID:	25521	Length:	995	Species:	Homo sapiens
Sequence 2:	XP_006239770.1	Gene:	Srbd1 / 301665	RGDID:	1562788	Length:	983	Species:	Rattus norvegicus

Alignment Length:	996	Identity:	810/996 - (81%)
Similarity:	888/996 - (89%)	Gaps:	17/996 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMP 65
            |.||.:|.|:|.::...:||.||||||||.||||:||||.|||||||.|:|::|..|.||.|:.|
  Rat     4 MPSLRKRTKIQTENAEPRDECSSFSELSSGSEEDNKEDSIWEPQKKVLRNRRRPASKGSKRKQGP 68

Human    66 RVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRT 130
            ||||:|.|:.|.|:.|.|||||||.|||.:..||:...||.|..|||||..|||.|.  |..:
  Rat    69 RVKKSAQQVHDISKDVAVKEELNSPVAIVNANLEEENQKLHTTNTLKTAAKKQKNAG--HGAK-- 129

Human   131 KKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPV 195
            |:|||:|||::||..||..::.|.||||.. ...||| |::|.|||.||.||:||||:.|||:|.
  Rat   130 KRLKVDEETNQASPFEGGESNVEAPSTSED-RDMCKK-ESEDSFTFEQSPLKRIKTESCPQGRPA 192

Human   196 KFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADS 260
            :.| .|:..|||||||||:|||||||||||||:|||||||||||||||||:|||||||||||||.
  Rat   193 RVP-GASDIKEEVEMNWDIVQVLSERTNIEPWICANIIRLFNDDNTIPFIVRYRKELINNLDADF 256

Human   261 LREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQ 325
            ||||:|||:|||.|||||||.|||||||||||||||:|:|||||||||||||||||.||||||||
  Rat   257 LREVRQTLDELRDVAKKVHSRIQKIKKEGKMSECLLQALLNCKTFEELEHVSAPYKMGSKGTKAQ 321

Human   326 RARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKDTLDFIRNL 390
            ||:||||||||..|||.||:|:|.|||||||||||.|:|||.|||||||||||||||||||||:|
  Rat   322 RAKQLGLEGAAWTLLENPGQLNLPSYIRPDVKGLSELKDIETGVQHILADMIAKDKDTLDFIRDL 386

Human   391 CQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTVKVNIS 455
            |:.|::|||||||||||||||||:||||.|||:|||||||||||||||||||||||:||||||||
  Rat   387 CKHRYICIQSSLAKVSSKKVNEKEVDKFQLYQNFSCNIRNIHHHQILAINRGENLKILTVKVNIS 451

Human   456 DGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMM 520
            ||||:||||||||||||||.||||||||||:|||:|||||||.||||||.||||||||||:||||
  Rat   452 DGVKNEFCRWCIQNRWRPRGFARPELMKILHNSLDDSFKRLIVPLLCRELRAKLTSDAEKQSVMM 516

Human   521 FGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLL 585
            ||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
  Rat   517 FGQNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLL 581

Human   586 LNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDP 650
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   582 LNFNCNTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDP 646

Human   651 NLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSE 715
            |||||||||||||||||||||.:||||||||||||||||||||||||||||||||||||||||||
  Rat   647 NLRSAVSIARRVQDPLAELVKFDPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSE 711

Human   716 VLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCS-Q 779
            ||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||||||| |
  Rat   712 VLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFVRVNQDYIRTFCSGQ 776

Human   780 QTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSIG 844
            .|::|||.|..|:       ||.||.||||:|  .:|.|.|||||:|||||||||||:||||.||
  Rat   777 HTDSSGQSQEAAM-------VTKEKPGKKKNK--ADVALTPNPLDETCIHPESYDIAVRFLSFIG 832

Human   845 GTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRS 909
            |||||:|||||||||||.|.|||:||.|||||||.|||||||||||||::||.||||||||||||
  Rat   833 GTLYEIGKPEMQQKINSSLGKEGIEKTAERLQTTAHTLQVIIDGLSQPKTFDIRTDFDKPDFKRS 897

Human   910 IVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVE 974
            ||||.|||:||:||||||||||||:||||||||:||||||.:||||||||||||||||||||:||
  Rat   898 IVCLADLQVGTILTGKVENATLFGVFVDIGVGKAGLIPIRFITEAKLSKTKKRRSLGLGPGEKVE 962

Human   975 VQVLNIDIPRSRITLDLIRVL 995
            |:||::|||||||:|||:|||
  Rat   963 VKVLSVDIPRSRISLDLLRVL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..81		38/57 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..165		18/44 (41%)
		Tex	208..991	CDD:225094	691/783 (88%)
		Tex_N	219..414	CDD:286460	169/194 (87%)
		Tex_YqgF	538..663	CDD:293526	122/124 (98%)
		HHH_3	705..767	CDD:289597	61/61 (100%)
		S1_Tex	919..990	CDD:240190	60/70 (86%)
Srbd1	XP_006239770.1	Tex	206..980	CDD:225094	690/782 (88%)
		Tex_N	215..410	CDD:286460	169/194 (87%)
		Tex_YqgF	534..659	CDD:293526	122/124 (98%)
		HHH_3	701..763	CDD:289597	61/61 (100%)
		S1_Tex	907..978	CDD:240190	60/70 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83690340
Domainoid	1	1.000	317	1.000	Domainoid score	I14557
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	1581	1.000	Inparanoid score	I2456
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D12277at314146
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto130556
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.370