DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRBD1 and ZK973.1

DIOPT Version :9

Sequence 1:	NP_060549.4	Gene:	SRBD1 / 55133	HGNCID:	25521	Length:	995	Species:	Homo sapiens
Sequence 2:	NP_491362.1	Gene:	ZK973.1 / 172040	WormBaseID:	WBGene00022830	Length:	745	Species:	Caenorhabditis elegans

Alignment Length:	827	Identity:	238/827 - (28%)
Similarity:	385/827 - (46%)	Gaps:	148/827 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   195 VKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDAD 259
            ::||......||..|:|....|              .::.||.:.....:|.|||.::...|..:
Worm    13 LQFPIEYFIHKEVHELNSTQAQ--------------RLVSLFKNGCETAYIARYRGDVHGYLAPE 63

Human   260 SLREVQQTLEELRAVAKKVHSTIQKI--KKEGKMSECLL-KAMLNCKTFEELEHVSAPYKTGSKG 321
            .:|:..:...:.:.:..||.|.|..:  |..|...:.:: :....|:.|:|:..:|..|.||::.
Worm    64 KIRKAMEAYVDAKNLNNKVSSAISTVTAKVAGAQEKIIVTERFKRCEEFDEVTDISKEYSTGTRK 128

Human   322 TKAQRARQLGLEGAARALLEKPGEL----SLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKD 382
            |||..||.||||..|:::|:  |..    ||||      .||.|::|:|..::..|||:|.:|::
Worm   129 TKANIARALGLEPPAQSILD--GNFVDFKSLLS------NGLKTVKDVEEHLKICLADLINRDEE 185

Human   383 ------TLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDK---FLLYQHF---SCNIRNIHHHQ 435
                  .:|.::..|:     :.:.|::.:.|  |.||::|   ...|::|   ..|..:|..|.
Worm   186 VRKVSANIDILKKECR-----VSAKLSREAEK--NRKDLEKRGIIEKYKNFIGEKWNAEDIRDHT 243

Human   436 ILAINRGENLKVLTVKVNISDGVKDEFCRWCIQNRWRPRSFARPELMKILY--------NSLNDS 492
            :.|:|:|.:..::|               |.|:..:....:..|...|.:|        .:|..|
Worm   244 VSALNKGFDEGIIT---------------WKIECEFNDAKYIHPFSRKSVYFGMKNFYQEALAYS 293

Human   493 FKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISP 557
            .|....|.:.|:....|...|:..|:::||.|:.|||....:..:.::.:||| :...|.|.:.|
Worm   294 IKNYFIPRIERKMANHLKDKAKDRSIVLFGENVDQLLSQEGIRDKFVIALDPG-RSKIKTAFLKP 357

Human   558 TSQILHTDVVYLHCGQGFREAEKIKTLLLNFNCST------VVIGNGTACRETEAYFADLIMKNY 616
            |.:::......::   |.|.......||..::..|      ..|||||....|:...:|:|..|.
Worm   358 TGEVVDMSSFSIY---GTRFDGGGVDLLKKWSQQTERKDIVFAIGNGTNTYNTQIAVSDMINSNV 419

Human   617 F-APLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLR--SAVSIARRVQDPLAELVKIEPKHIG 678
            | ..::|.||||.|.|||.||.:|.|.:|. |.:..:.  |||||.||:.||::|.|||||:|:|
Worm   420 FPKEINVSYCIVPEHGASKYSCTPSAIEEF-GENAEITEISAVSIGRRLIDPMSEYVKIEPQHLG 483

Human   679 VGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFI 743
            .|.||..|....|..:|.:||.:.|||.|||:|..|:.||:.|.|||...||.|:::||:||.|.
Worm   484 KGQYQLSVDPKKLNESLLNVVRDRVSFNGVDLNTASKNLLQRINGLNEKTAKEIVQYREQNGRFR 548

Human   744 NREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKK 808
            :|.:||:|||:|..:|||||||:                        .|:...|.|....|:..|
Worm   549 SRAELKEVKGIGALTFQQCAGFL------------------------TVSRPDDAEDGPPKKKFK 589

Human   809 KSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAE 873
            ||.|:    .:.||.|:|.:||:.|    |...|:.|.| .|...::..:|.||    .:.::..
Worm   590 KSSTS----KEWNPFDETIVHPDDY----RTGESLLGKL-NVSIEDITGRIKSF----SISRLTA 641

Human   874 RLQTTVHTLQVIIDGLSQPESFDFRTDF-DKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVD 937
            .....::.||          :...:|.. ..|..:..:..:.||..|...||.|.|.|.||:|:|
Worm   642 EEAKVLNLLQ----------NLTLKTKMKPPPPLRTKVGQIRDLAEGQRFTGTVSNKTDFGVFID 696

Human   938 IGVGKSGL--------------IP-IRNVTEAKLSKTKKRRSLGLGP 969
            ||||:.||              :| :.:..|..:.|.::...:.|.|
Worm   697 IGVGQDGLAHISHFKDGHYSLMLPSVNDSVEVVIDKIREDGKISLSP 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..165
		Tex	208..991	CDD:225094	234/814 (29%)
		Tex_N	219..414	CDD:286460	52/207 (25%)
		Tex_YqgF	538..663	CDD:293526	44/133 (33%)
		HHH_3	705..767	CDD:289597	34/61 (56%)
		S1_Tex	919..990	CDD:240190	21/66 (32%)
ZK973.1	NP_491362.1	Tex	27..742	CDD:225094	232/810 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161464992
Domainoid	1	1.000	75	1.000	Domainoid score	I6429
eggNOG	1	0.900	-	-		E1_COG2183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2079
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62824
OrthoDB	1	1.010	-	-		D321814at33208
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto22274
orthoMCL	1	0.900	-	-		OOG6_104871
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4297
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800