DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRBD1 and srbd1

DIOPT Version :9

Sequence 1:	NP_060549.4	Gene:	SRBD1 / 55133	HGNCID:	25521	Length:	995	Species:	Homo sapiens
Sequence 2:	XP_004914811.2	Gene:	srbd1 / 100497933	XenbaseID:	XB-GENE-6035351	Length:	992	Species:	Xenopus tropicalis

Alignment Length:	1018	Identity:	654/1018 - (64%)
Similarity:	788/1018 - (77%)	Gaps:	49/1018 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMP 65
            |:.||||||...|  |.|.:.|..|...|..:.|...:..|.|::|.|:::.|..|..:||::.|
Frog     1 MAGLPRRAKQNTQ--VSKQDLSFMSISESEDDGDSPHEDEWTPEQKAPKTKAQQKPSTAKPRKAP 63

Human    66 RVKKNAPQISDGSEVVVVKE---ELNSSVA----IADTALEDRKNKLDTVQTLKTAKTKQKCAAQ 123
            ..|..|...|:.:.....||   :|::::|    :..|..:::|       |.|....|:|....
Frog    64 AKKPTAKPKSEAAPRKPRKEKSTKLDTNIAQEGLLGQTIKQEKK-------TPKKTPVKKKMVQS 121

Human   124 PHTVRRTKKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKK------------EENDDDFTF 176
            |    ..:|:.::||....       ..|:.|||||:..||..|            ||..|||||
Frog   122 P----VPEKVPIKEERRSL-------GISDFPSTSTLPKGTSIKEEMLFKREEATDEEPPDDFTF 175

Human   177 GQSALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNT 241
            |:..|||:|..:...|:|||. .|:::.....||||:.|:||||:||:|||||:|:|:||:||||
Frog   176 GEPPLKKLKPSSDSFGKPVKH-MNSSAAHGGHEMNWNFVEVLSEKTNVEPWVCSNLIQLFHDDNT 239

Human   242 IPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFE 306
            ||||.|||||||||||||:||||||.|||||:||||.|:.|:|:|||||::..|..:||||::.:
Frog   240 IPFIARYRKELINNLDADALREVQQGLEELRSVAKKAHTLIEKLKKEGKLNSGLHTSMLNCRSAD 304

Human   307 ELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQH 371
            |:|||.|||||||||||||||:|||||.|||.|:|.|.:|:|.|||..:|:|||||||||:||||
Frog   305 EIEHVYAPYKTGSKGTKAQRAKQLGLETAARGLIETPAQLNLFSYINSNVEGLSTLQDIEMGVQH 369

Human   372 ILADMIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKV--NEKDVDKFLLYQHFSCNIRNIHHH 434
            |||||.||||||::.||:||::.:|.|.|:|||.:.|:.  |.||||||.||..|:|:|..||||
Frog   370 ILADMFAKDKDTVEHIRSLCKQNNVTIHSTLAKATGKEKEGNVKDVDKFHLYHDFTCSINRIHHH 434

Human   435 QILAINRGENLKVLTVKVNISDGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYP 499
            ||||||||||||:||||||:.|.|||.|||||:..||||:.||||||||||:||:.||:|||:||
Frog   435 QILAINRGENLKILTVKVNVPDRVKDAFCRWCVNERWRPKQFARPELMKILHNSVEDSYKRLLYP 499

Human   500 LLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHT 564
            |||||:|:||||||||||:||||||||||||.:||.|||:|||||||||||||||||||:|||||
Frog   500 LLCREYRSKLTSDAEKESIMMFGRNLRQLLLANPVRGRTIMGVDPGYKHGCKLAIISPTNQILHT 564

Human   565 DVVYLHC--GQGFREAEKIKTLLLNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIV 627
            ||||||.  |.|..||||||.|||||||.||.|||||||||||.||||||.:.:||||||||||.
Frog   565 DVVYLHTGHGHGIHEAEKIKRLLLNFNCCTVAIGNGTACRETERYFADLIQRRFFAPLDVVYCIA 629

Human   628 SEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLK 692
            :|||||||||||||.||||.|||||||||||||||||||||||||||||||||||||||||||||
Frog   630 NEAGASIYSVSPEAAKEMPDLDPNLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLK 694

Human   693 ATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPK 757
            |||||||||||||||||||||||.|||||||||:.||||||||||||||||.|||||.|||||||
Frog   695 ATLDSVVEECVSFVGVDINICSETLLRHIAGLNSARAKNIIEWREKNGPFITREQLKLVKGLGPK 759

Human   758 SFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNP 822
            |||||||||||||:|||:||..|  .:|..:|   |..|:...::.||||||.||:.||.|.|||
Frog   760 SFQQCAGFIRINQEYIRSFCRDQ--PTGNPRG---TDQANPSSSSSKQGKKKGKTSANVPLNPNP 819

Human   823 LDQTCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIID 887
            |||||||||||.|||||::.:||...:.|..:::.::|.|:::|.:|.:.::|.|||||||:|||
Frog   820 LDQTCIHPESYSIAMRFITLVGGNSNDTGTQKIKDQVNRFIQREAVESVGQKLNTTVHTLQLIID 884

Human   888 GLSQPESFDFRTDFDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVT 952
            ||.|||.||.||:|||.|||.:|||||||::||:||||||||||||:||||||||:||||||.:|
Frog   885 GLCQPEGFDIRTEFDKADFKTNIVCLEDLRVGTILTGKVENATLFGVFVDIGVGKAGLIPIRYIT 949

Human   953 EAKLSKTKKRRSLGLGPGERVEVQVLNIDIPRSRITLDLIRVL 995
            ||||...|:||||||||||||||:|:::|:.:|||:|||||||
Frog   950 EAKLPSQKRRRSLGLGPGERVEVKVMSVDVRQSRISLDLIRVL 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRBD1	NP_060549.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..81		15/57 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..165		11/44 (25%)
		Tex	208..991	CDD:225094	582/786 (74%)
		Tex_N	219..414	CDD:286460	134/196 (68%)
		Tex_YqgF	538..663	CDD:293526	106/126 (84%)
		HHH_3	705..767	CDD:289597	56/61 (92%)
		S1_Tex	919..990	CDD:240190	53/70 (76%)
srbd1	XP_004914811.2	PTZ00449	<25..>190	CDD:185628	49/182 (27%)
srbd1	XP_004914811.2	Tex	208..988	CDD:225094	581/784 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I10877
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9994
Inparanoid	1	1.050	1266	1.000	Inparanoid score	I2022
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D321814at33208
OrthoFinder	1	1.000	-	-		FOG0006115
OrthoInspector	1	1.000	-	-		oto149210
Panther	1	1.100	-	-	LDO	PTHR10724
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4297
SonicParanoid	1	1.000	-	-		X5053
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.190