DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ODAD2 and cut15

DIOPT Version :9

Sequence 1:	XP_024303817.1	Gene:	ODAD2 / 55130	HGNCID:	25583	Length:	1107	Species:	Homo sapiens
Sequence 2:	NP_587868.1	Gene:	cut15 / 2539426	PomBaseID:	SPCC962.03c	Length:	542	Species:	Schizosaccharomyces pombe

Alignment Length:	754	Identity:	141/754 - (18%)
Similarity:	247/754 - (32%)	Gaps:	258/754 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   378 NYKGKGS--AKEIQEDKHTGKLEKPRPSVSHGRAQLLRKSAEKIEETVSDSSS---ESEEDEEPP 437
            ||||||:  |.|::..:.|.::|             :||  :|.||.::...:   ..|..||..
pombe    15 NYKGKGTFQADELRRRRETQQIE-------------IRK--QKREENLNKRRNLVDVQEPAEETI 64

Human   438 DHRQEASADLPSEYWQIQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINL 502
            ...|:...||..|. |:..|:|.|...:..|.:.|....|. :|::||
pombe    65 PLEQDKENDLELEL-QLPDLLKALYSDDIEAQIQATAKFRK-ALSKET----------------- 110

Human   503 LETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKR 567
                                 ||.| |.::|.|.:|..|..|...:..||..|:..:.|||
pombe   111 ---------------------NPPI-QKVIDAGVVPRFVEFLSHENNLLKFEASWALTNVA---- 149

Human   568 ARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAG 632
                                                               |.|......:.:|.
pombe   150 ---------------------------------------------------SGSSNQTHVVVEAN 163

Human   633 GIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAI 697
            .:|:...||.:|.:::....|..|                       .|:..::...::|    :
pombe   164 AVPVFVSLLSSSEQDVREQAVWAL-----------------------GNIAGDSPMCRDH----V 201

Human   698 YQCAEDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLV 762
            .||             |.|:|   |||..::..||:.:..:.|..|..........::.:|..::
pombe   202 LQC-------------GVLEP---LLNIIESNRRLSMLRNSTWTLSNMCRGKNPQPDWNSISQVI 250

Human   763 GLLT----DQPEEVLVNVVGA---LGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKA 820
            .:|:    ...|:|||:.:.|   |.:...|:...:|  ..|..:.||.||:..:..:.....::
pombe   251 PVLSKLIYTLDEDVLVDALWAISYLSDGANEKIQAII--DAGIPRRLVELLMHPSAQVQTPALRS 313

Human   821 VGACAVEPESMMWGLTLSSRLKYSGMMRGHCSLKLLGSSDPPNFVFFRSRKLRNRIIDRLDGVRL 885
            ||                               .::...|           ::.::|.....:..
pombe   314 VG-------------------------------NIVTGDD-----------VQTQVIINCGALSA 336

Human   886 LWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELI---VNLLKSDNKEVLASVCAA 947
            |.|||.:|...|:..|.|.    |.|..........:|....:|   ::||.:.:.::....|.|
pombe   337 LLSLLSSPRDGVRKEACWT----ISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWA 397

Human   948 ITNI----AKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAV 1008
            |:|.    |:..:.:..:.:.|.:..|..|....:||:.....:.|       .|.:..||
pombe   398 ISNATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGI-------ENILRVGE---- 451

Human  1009 APLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHE-----NGAV--KATQ------REDDEDE 1060
              |.|....:..|::     |:|  .|||.....:||     |..:  ||..      .|:||.|
pombe   452 --LDRANNPDKINLY-----AVY--VEDAGGMDLIHECQNSSNSEIYQKAYNIIEKFFGEEDEIE 507

Human  1061 DLYDDPLPLNLLLDMVGSPDQDLQEAAAGCISNIRRLAL 1099
            :|..:.:...........|..|.|.:|    :|...:|:
pombe   508 ELEPETVGDTFTFGTTQEPAGDFQFSA----TNAEDMAM 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ODAD2	XP_024303817.1	PLN03200	<449..684	CDD:331927	36/234 (15%)
		armadillo repeat	454..479	CDD:293788	6/24 (25%)
		armadillo repeat	489..521	CDD:293788	0/31 (0%)
		armadillo repeat	528..564	CDD:293788	11/35 (31%)
		armadillo repeat	571..617	CDD:293788	0/45 (0%)
		PLN03200	<625..>823	CDD:331927	37/204 (18%)
		armadillo repeat	627..659	CDD:293788	7/31 (23%)
		armadillo repeat	665..702	CDD:293788	4/36 (11%)
		armadillo repeat	710..741	CDD:293788	8/30 (27%)
		armadillo repeat	749..785	CDD:293788	8/42 (19%)
		armadillo repeat	876..908	CDD:293788	9/31 (29%)
		HEAT_2	885..990	CDD:316194	24/111 (22%)
		armadillo repeat	926..951	CDD:293788	6/27 (22%)
		armadillo repeat	958..995	CDD:293788	6/36 (17%)
		armadillo repeat	999..1030	CDD:293788	5/30 (17%)
cut15	NP_587868.1	SRP1	3..531	CDD:227396	137/737 (19%)
		IBB	8..99	CDD:280005	27/99 (27%)
		armadillo repeat	73..106	CDD:293788	10/34 (29%)
		ARM	115..235	CDD:237987	35/217 (16%)
		armadillo repeat	116..148	CDD:293788	8/31 (26%)
		armadillo repeat	156..192	CDD:293788	8/58 (14%)
		armadillo repeat	198..233	CDD:293788	13/54 (24%)
		ARM	199..319	CDD:237987	30/172 (17%)
		armadillo repeat	250..275	CDD:293788	6/24 (25%)
		armadillo repeat	283..361	CDD:293788	20/125 (16%)
		ARM	344..446	CDD:237987	21/112 (19%)
		armadillo repeat	367..400	CDD:293788	7/32 (22%)
		armadillo repeat	412..446	CDD:293788	6/40 (15%)
		Arm_3	462..>501	CDD:292804	11/45 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910