Protein Alignment FANCL and Fancl

DIOPT Version :10

• Sequence 1: XP_011531241.1
• Gene: FANCL / 55120
• HGNCID: 20748
• Length: 403
• Species: Homo sapiens
• Sequence 2: NP_649974.1
• Gene: Fancl / 41231
• FlyBaseID: FBgn0037781
• Length: 381
• Species: Drosophila melanogaster
• Alignment Length: 386
• Identity: 90/386 - (23%)
• Similarity: 155/386 - (40%)
• Gaps: 65/386 - (16%)

Human    24 VYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELK 88
            :..|.:.::.....|::.||.               ...|.|:...||:.:::.   :.....||
  Fly    29 IIRGVLGSEDTWRRLKLYLPH---------------HPALHGFQLYVQESLEYK---LYTSANLK 75

Human    89 M----LLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKL---------VYADTCFSTIKLKA 140
            :    |||..|.:..::......|.....|..| |.:.:|.|         :..|...|.|:. :
  Fly    76 LQDDWLLEDFLDHLPKILPAQKAPTVPKELCRE-GNIYYDILALYKSNEYCLQVDEACSMIRF-S 138

Human   141 EDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQVNSPQVTDQAKMDVKIAVLPSSLIS 205
            |.....:|.:.||:.:.       ..:|..:|.|.|            ..:|..|.|   .:|..
  Fly   139 EFTDFEQHYLELKIPSL-------LLLDHSLPDCVS------------LGEMLTKSA---GNLEE 181

Human   206 IYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEV-DPRHPTMLP 269
            ..:.|...:|.|:.|:|...:|||...||:|.........|...|.:.|.:.:.: ||.......
  Fly   182 ALNLFRKLLEDLRPFYDNFMDIDELCHVLQPSPISSKHKTRLFPLKDRVYLKLTIADPFACIASM 246

Human   270 ECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEI-DFP------ARAILEKSDFTMDC 327
            ....:|....|..|...||..:..||.|.::.:||..:.:: .||      ...:.|:.:..:.|
  Fly   247 SLKIIGPTEEVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKLDEEDNEELRC 311

Human   328 GICYAYQLD-GTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYC-SKVS 386
            .||:||:|| |.:|...|||::|....|.:||.||.:.|:..:....:.||:||:| :|:|
  Fly   312 NICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLS 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FANCL	XP_011531241.1	FANCL_d1	5..93	CDD:462888	12/72 (17%)
		FANCL_d2	108..217	CDD:465900	23/117 (20%)
		FANCL_d3	220..315	CDD:465901	25/102 (25%)
		RING-CH-C4HC3_FANCL	326..383	CDD:438153	24/58 (41%)
Fancl	NP_649974.1	FANCL_d1	8..95	CDD:462888	14/83 (17%)
		DRWD-N_DmFANCL	108..186	CDD:467643	19/101 (19%)
		DRWD-C_DmFANCL	194..292	CDD:467647	24/97 (25%)
		FANCL_C	307..376	CDD:463350	26/66 (39%)