DRSC/TRiP Functional Genomics Resources

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Protein Alignment FANCL and fancl

DIOPT Version :10

Sequence 1:XP_011531241.1 Gene:FANCL / 55120 HGNCID:20748 Length:403 Species:Homo sapiens
Sequence 2:NP_998147.1 Gene:fancl / 406255 ZFINID:ZDB-GENE-040426-1045 Length:371 Species:Danio rerio


Alignment Length:387 Identity:212/387 - (54%)
Similarity:292/387 - (75%) Gaps:22/387 - (5%)


- Green bases have known domain annotations that are detailed below.


Human     8 LLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKNARLLCSWQLRTILSGYHRIVQQ 72
            |:|:.||::..|:.||:|:|||:...:||.:||.||.|.|:|.|:|.|.||::.:|.||..||:|
Zfish     5 LMRESPLIIALNKEKTLYDGFITVLEKDFRIRISLPPDHQMKRAKLHCCWQMKRLLHGYQHIVKQ 69

Human    73 RMQHSPDLMSFMMELKMLLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIK 137
            |:|||..||:|::||:.:||||||::....:. .|||:||.||.|:..||||||::.|..|.|::
Zfish    70 RLQHSTTLMAFILELRTVLEVALKSQPGCQSF-SPPQYYSQLITEMEILGWDKLLFIDAEFRTLQ 133

Human   138 LKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQVNSPQVTDQAKMDVKIAVLPSS 202
            |||||::||:|.||:|||:|||||:|::..|.|:|...:||.|                    |:
Zfish   134 LKAEDSAGRQHAITVKLKSKYPAEAPEFSADLPIPLVITWTSQ--------------------ST 178

Human   203 LISIYSQFLAAIESLKAFWDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTM 267
            |.:::||||..:|:|..||.|:|||||||||||||||.::.:.||||:||||||.:::|||||.|
Zfish   179 LANVHSQFLLNVEALSDFWSVLDEIDEKTWVLEPEKPTKADSTRRIAIGNNVSIKVQIDPRHPKM 243

Human   268 LPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFTMDCGICYA 332
            ||||..|||:|||.||..||:.|:|||:|:.:||||:||||||:||:....|||.|:::|||||:
Zfish   244 LPECCLLGAEHVVTPLRNKLNANMHLWNPDCTVLQNMKDVLEIEFPSPTTHEKSSFSVECGICYS 308

Human   333 YQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYCSK-VSKLLITSH 393
            |:|:..||||||::.:|||||||:|||||||||.||||||||:||||||||| ::..::|.:
Zfish   309 YRLESAIPDQVCNDPRCGQPFHQVCLYEWLRGLPTSRQSFNIVFGECPYCSKPITVKMVTGN 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FANCLXP_011531241.1 FANCL_d1 5..93 CDD:462888 41/84 (49%)
FANCL_d2 108..217 CDD:465900 48/108 (44%)
FANCL_d3 220..315 CDD:465901 65/94 (69%)
RING-CH-C4HC3_FANCL 326..383 CDD:438153 43/56 (77%)
fanclNP_998147.1 FANCL_d1 3..90 CDD:462888 41/84 (49%)
FANCL_d2 104..193 CDD:465900 48/108 (44%)
FANCL_d3 195..291 CDD:465901 65/95 (68%)
RING-CH-C4HC3_FANCL 302..359 CDD:438153 43/56 (77%)

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