Protein Alignment PRPF38B and CG1622

DIOPT Version :10

• Sequence 1: NP_060531.2
• Gene: PRPF38B / 55119
• HGNCID: 25512
• Length: 546
• Species: Homo sapiens
• Sequence 2: NP_572872.1
• Gene: CG1622 / 32282
• FlyBaseID: FBgn0030468
• Length: 398
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 211/484 - (43%)
• Similarity: 275/484 - (56%)
• Gaps: 110/484 - (22%)

Human    32 GGATKPAVSGKQGNVLPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHV 96
            ||..|   :|||.|.||.||||.:||||.:||.||.||.||||.|::||||||||||||::|.|:
  Fly    12 GGGKK---AGKQHNTLPFWGNESSMNLNALILANIQSSSYFKVHLFKLKTYHEVVDEIYYQVKHM 73

Human    97 EPWEKGSRKTAGQTGMCGGVRGVGTGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALG 161
            ||||:|||||:|||||||||||||.|||||||:||||||:||:|||||:.||:.||||.||||||
  Fly    74 EPWERGSRKTSGQTGMCGGVRGVGAGGIVSTAYCLLYKLYTLRLTRKQINGLLNHTDSAYIRALG 138

Human   162 FMYIRYTQPPTDLWDWFESFLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQ 226
            |||:||||||.||:||:|.:|.|||::|||||||.|:|||:|:..|:|||:||||||||||||:|
  Fly   139 FMYLRYTQPPGDLYDWYEDYLQDEEEIDVKAGGGQVLTIGQMVYQFMTKLDWFSTLFPRIPVPIQ 203

Human   227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSF 291
            |.|:::|:...|:         :.:..|           .||..||...:..      |.|::..
  Fly   204 KQIEKRIEQYCRE---------QGVTVH-----------QLSTGRSTAGTGG------GPGAAGQ 242

Human   292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356
            |.:.:...|                  ..::||   ...|...:..|||.:..:..:.|:...||
  Fly   243 DADYQDYPE------------------GGVERG---SGGRGGGQAGSRSNAYPQPNNYRNDYDER 286

Human   357 E-------KENERGRRRDRDY------DKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKD 408
            :       ....|||....||      .:....|||:||:|.|::                 :||
  Fly   287 DYYAAASGSSYGRGRGGYEDYPPAPLPPQMPYGERERERDRDRDK-----------------NKD 334

Human   409 DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
            ..|||     ||.:|||:        ||..||||:   ||||||:.:|.:|         :|.|.
  Fly   335 YDRHR-----SKHKKKHN--------HRQSSRSRS---RSRSRSRHRSERH---------ERKRD 374

Human   474 GSQGRTDSVEKSKKREHSPSKEKSRKRSR 502
            |.     ..|:|.|..|:...|:..:|.|
  Fly   375 GG-----GYERSSKSRHNEHYEERERRHR 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPF38B	NP_060531.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		3/7 (43%)
		PRP38	47..227	CDD:460901	135/179 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..546		67/287 (23%)
		U2AF_lg	463..>545	CDD:273727	10/40 (25%)
CG1622	NP_572872.1	PRP38	24..205	CDD:460901	136/180 (76%)