DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF26B and CG14535

DIOPT Version :9

Sequence 1:	NP_060482.2	Gene:	KIF26B / 55083	HGNCID:	25484	Length:	2108	Species:	Homo sapiens
Sequence 2:	NP_001285726.1	Gene:	CG14535 / 34073	FlyBaseID:	FBgn0031955	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	1404	Identity:	353/1404 - (25%)
Similarity:	532/1404 - (37%)	Gaps:	441/1404 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   420 FSGILQTSPPPAPPCLLRAVNKVKDTPGLGKVKVMLRICSTLARDTSESSSFLKVDPRKKQITLY 484
            |.|.||.:|||.||.|:|.::. ::..|:||||||||:.............|:.:|.:|:|:||.
  Fly    15 FCGALQRAPPPMPPTLIRRLSS-RECYGVGKVKVMLRVADRDRNSGGTEPDFMALDKKKRQVTLT 78

Human   485 DPLT-CGGQNAFQKRGNQV-PPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGH 547
            ||.| |....|.|:|...| .|||||||.:|..:..|::|||..::|||.:|:.|:|||:...|:
  Fly    79 DPRTACPPPQAAQERAPMVAAPKMFAFDNLFTGEDKQSDVCASALSEVIPAVLEGSDGCLLAMGY 143

Human   548 AKLGKSYTMIGK------------DDSMQNLGIIPCAISWLFKLINERKEKTGARFSVRVSAVEV 600
            ...|::.|::|:            .....:||..||||:||:|.|.||::|:|||||||||||
  Fly   144 PATGQAQTVLGELGGGSGSGSASGSGVACSLGAAPCAIAWLYKGIQERRQKSGARFSVRVSAV-- 206

Human   601 WGKEENLRDLLSE--VATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAAIAS 663
             |......|.||:  :.:.:.:...|||:||.:|.:.|     .:||||||||:||.|||:|:|.
  Fly   207 -GVSATKPDALSQDLLISHAAESDDSPGIYLRDDFLGG-----PTELRAPTAERAALFLDSALAG 265

Human   664 R-------RSHQQDCDEDDHRNSHVFFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALSK 721
            |       .|....|...  ..|.:.||||:|||.:  |.|||::|||||||:||||.|.
  Fly   266 RLKSSGSTASGSSGCAAP--LESALIFTLHVYQYSL--SRKGGVAGGRSRLHIIDLGGCA----- 321

Human   722 NREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISAAVGSYA 786
            ||.||    |.||.:||::||:::|.:|.|:|:..|..||::.|..:.|...::||:... .||.
  Fly   322 NRNGG----LPLSGIGNILLAILSGQRHPPHKDHPLTPLLKDCLAPITCHVAIVAHVRPE-QSYQ 381

Human   787 ETLSTIQIASRVLRMKKKKTKY-------TSSSSGGESSCEEGRMRRPTQLRPFHTRATVDPDFP 844
            :.|||||||||:.|::::|.:.       .:...||..|.
  Fly   382 DALSTIQIASRIHRLRRRKHRVPMPLAVGLAQGLGGNGSS------------------------- 421

Human   845 IAHLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPAEAG 909
             |...:||   ||||.|.|||||:|||..|      ||.|.||.::|.:     |.||:| ....
  Fly   422 -AGSGADP---SSSEISADTVIYMGPNDDA------TDGEHPPVYLPSL-----TAGDNR-GVMS 470

Human   910 EAAAGKSERDCLKCNTFAELQERLDCIDGSEEPSSFPFEELPAQFGPEQASRGPRLSQAAGASPL 974
            :|..|                      .|.|:|.|            :.||..|.:.:.|.|
  Fly   471 KALKG----------------------SGLEKPPS------------KSASNSPMMMKKAMA--- 498

Human   975 SESDKEDNGSE-GQLTNREG------PELP--ASKMQRSHSPVPAAAPAHSPSPASPRSVPGSSS 1030
            :|..|:..||. |.|..:.|      |.:|  ..::|...||:|  .|.|..|..|....|..|.
  Fly   499 AEKAKKLPGSHTGSLKRQAGAGACSSPMIPHEQPQIQAMGSPIP--IPRHMVSKGSMVPSPKGSP 561

Human  1031 QHSASPLVQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLS------------KTSEYKPPS 1083
            ...|.|......|::....:....:::|       ||:..|.::            |..|.....
  Fly   562 MRRAHPGAALEQLEAGMRKITEEQWIDG-------PRVSRAKVAEARHLMREVNHVKQCETWVDG 619

Human  1084 SPSQRCKVYTQKGVLPSPAPLPPSSKDSGVASRESLLQPEVRTPPVGMSPQVLKKSMSAGSEGFP 1148
            ..||.|:..|...:     |....|:..|....::..:..:|......:.||.:.::||
  Fly   620 PKSQSCRSLTACNL-----PAAGGSQTQGYGFMDAHKKTMIRQWVENQTTQVFQSTVSA------ 673

Human  1149 ETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLDSGRPTSIISF 1213
                                                                   |..||::...
  Fly   674 -------------------------------------------------------SNSPTALHWK 683

Human  1214 NSDCSARALASGSRPV-SIISSISEDLECYSSTAPVSEVSITQFLPLPKMSLDEKAQDAGSRRSS 1277
            .|....::|....||. :...|:..:..|:.|            |||    ||....|
  Fly   684 LSQLKQKSLDLPDRPAFNPEPSLDLNQPCFES------------LPL----LDPAPPD------- 725

Human  1278 ISSWLSEMSAGSEGEQSCHSFIAQTCFGHGEAMAEPVASEFVSSLQNTAVVCREKPKASPDNL-- 1340
                      |.|.|.|..|.:....    ..:.:|:.|..:|.                |||
  Fly   726 ----------GDEDEDSGPSEVPPAL----PLLDDPLGSRDISQ----------------DNLHR 760

Human  1341 LILSEMGDDSFNKAAPIKGCKISTVSKAMVTISNTANLSSCEGYIPMKTNITVYPCIAMSPRNIQ 1405
            ::...:..:..::|.               .:::.|:.|    :.|.:.:|   .|      .:|
  Fly   761 MLSRHVSREQLHEAE---------------LVASRASSS----HHPSQRSI---DC------GLQ 797

Human  1406 EPEAPTATPKAGPTLAQSRESKENSAKKEMKFEDPWLKREEEVKKETAHP--------------- 1455
            ..|...|.     |:::.|:            .||           :|||
  Fly   798 VTEEEIAR-----TMSRDRD------------HDP-----------SAHPLSALSHCDNISFVSS 834

Human  1456 -NEEGMMRCETATGPSNAETRAEQEQDGKPSPGDRLSSSSGEVSASPVTDNFRRVVDG------- 1512
             |    |.||:.   |....||.|:.|......:..:|.......:|....||..:..
  Fly   835 FN----MACESF---SECGERARQQFDQLARLHEIFTSQLAMAEVTPSAALFRTDIGSVFSEPVY 892

Human  1513 ---------CEMALPGLATQSPVHPNKSVKSSSLPRAFQKASRQEEPDSLSYYCAAETNGVGAAS 1568
                     |......|....|..|:.|....|||                     ..||:...:
  Fly   893 HFNVGQSSVCSEPAYRLTPSPPKQPSHSPSQGSLP---------------------SLNGIMEIA 936

Human  1569 GTPPSKATLEGKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQH------------SASGS 1621
            |             ...:.:|.:|.|... |.::|.    :.|.:|||            :|.|.
  Fly   937 G-------------MDDYALLRQPDGASD-PNLQKG----EKRFTPQHDDICELDEKSMAAAVGK 983

Human  1622 GTS-----SPLNQ-----PAAFPAGLPDEPSGKTKDASSSSKLFSAKLEQLASRSNSLGRATVSH 1676
            |.|     ..||:     |.|..:.||..|...:.:|..|.  ..:......|:.:.:.|...|.
  Fly   984 GNSLEDAQHKLNEITNILPLAAQSRLPLLPLNTSSEAYDSG--HDSNSTPRTSKHSGISRRAESG 1046

Human  1677 YECLSLERAESLSSVSSRLHAGKDGTMPRAGRSLGRSAG 1715
            |..::..|....||.:|.:..|:...:..:|.....|||
  Fly  1047 YHSVATVRDSDESSFASGMSKGQRHRITVSGTGAVTSAG 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF26B	NP_060482.2	KISc	450..798	CDD:276812	154/370 (42%)
		KISc	451..798	CDD:214526	153/369 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..825		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..917		12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..1166		49/249 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1406..1504		20/113 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1653		32/155 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1685..1799		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1814..1974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..287
CG14535	NP_001285726.1	Motor_domain	44..394	CDD:277568	155/371 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2404
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002018
OrthoInspector	1	1.000	-	-		otm40255
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4619
SonicParanoid	1	1.000	-	-		X1937
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.900