DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF26B and Kif26b

DIOPT Version :9

Sequence 1:	NP_060482.2	Gene:	KIF26B / 55083	HGNCID:	25484	Length:	2108	Species:	Homo sapiens
Sequence 2:	NP_001155137.1	Gene:	Kif26b / 269152	MGIID:	2447076	Length:	2112	Species:	Mus musculus

Alignment Length:	2116	Identity:	1862/2116 - (87%)
Similarity:	1941/2116 - (91%)	Gaps:	12/2116 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNSVAGNKERLAVSTRGKKYGVNEVCSPTKPAAPFSPESWYRKAYEESRAGSRPTPEGAGSALGS 65
            ||||||||||||||||||||||||:||||||:||.||||||||||||||||||||||||||||||
Mouse     1 MNSVAGNKERLAVSTRGKKYGVNEMCSPTKPSAPCSPESWYRKAYEESRAGSRPTPEGAGSALGS 65

Human    66 SGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGGSPGFGTGSPGSGSGGGSSPGSDRGVWCE 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 SGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGGSPGFGTGSPGSGSGGGSSPGSDRGVWCE 130

Human   131 NCNARLVELKRQALRLLLPGPFPGKDPAFSAVIHDKLQVPNTIRKAWNDRDNRCDICATHLNQLK 195
            ||||||||||||||:||||||.|||||||||||||||||||||||:|||||||||||||||||||
Mouse   131 NCNARLVELKRQALKLLLPGPLPGKDPAFSAVIHDKLQVPNTIRKSWNDRDNRCDICATHLNQLK 195

Human   196 QEAIQMVLTLEQAAGSEHYDASPCSPPPLSNIPTLVGSRHVGGLQQPRDWAFVPAPCATSNYTGF 260
            ||||||||||||||||||||.|..||||:|:|||||||||:|||||||:|||||||.|||.|||.
Mouse   196 QEAIQMVLTLEQAAGSEHYDTSLGSPPPISSIPTLVGSRHMGGLQQPREWAFVPAPYATSTYTGL 260

Human   261 ANKHGSKPSSLGVSNGAEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGTWSLSRTN 325
            .|||..||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 VNKHSGKPNSLGVSNGAEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGTWSLSRTN 325

Human   326 GVTLYPYQISQLMTESSREGLTEAVLNRYNADKPSACSVPASQGSCVASETSTGTSVAASFFARA 390
            |||||||||||||||:.||||||:.|||||||||:|.||||.|||||||||||||||||||||||
Mouse   326 GVTLYPYQISQLMTETGREGLTESALNRYNADKPAASSVPAPQGSCVASETSTGTSVAASFFARA 390

Human   391 AQKLNLSSKKKKHRPSTSSAAEPPLFATSFSGILQTSPPPAPPCLLRAVNKVKDTPGLGKVKVML 455
            |||||||||||||||||.|.||.||||||||||||||||||||||||||||||||||:|||||||
Mouse   391 AQKLNLSSKKKKHRPSTPSVAEAPLFATSFSGILQTSPPPAPPCLLRAVNKVKDTPGMGKVKVML 455

Human   456 RICSTLARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKRGNQVPPKMFAFDAVFPQDASQA 520
            |||||.|||||||||||||||||||||||||||||||||||||.:||||||||||||||||||||
Mouse   456 RICSTSARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKRSSQVPPKMFAFDAVFPQDASQA 520

Human   521 EVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGKDDSMQNLGIIPCAISWLFKLINERKE 585
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   521 EVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLGIIPCAISWLFKLINERKE 585

Human   586 KTGARFSVRVSAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTA 650
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 KTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTA 650

Human   651 EKAAFFLDAAIASRRSHQQDCDEDDHRNSHVFFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSC 715
            ||||||||||||||||:|||||||||||||:.|||||||||||||||||||||||||||||||||
Mouse   651 EKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSC 715

Human   716 VKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISA 780
            ||||||||||||||||||||||||||||||||||||||||||.|||||||||:||||||||||||
Mouse   716 VKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLTMLLRESLGNVNCRTTMIAHISA 780

Human   781 AVGSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHTRATVDPDFPI 845
            |..|||||||||||||||||||||||||||||||||||||||||||||||||||.||.|||:||:
Mouse   781 AASSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHARAPVDPEFPL 845

Human   846 AHLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPAEAGE 910
            |.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.|
Mouse   846 APLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPGEAAE 910

Human   911 AAAGKSERDCLKCNTFAELQERLDCIDGSEEPSSFPFEELPAQFGPEQASRGPRLSQAAGASPLS 975
            |||.|||||||||||||||||||||||||||||.|||||||.|||||||.|...||||.|....|
Mouse   911 AAASKSERDCLKCNTFAELQERLDCIDGSEEPSKFPFEELPIQFGPEQAGRCAPLSQAVGPDTPS 975

Human   976 ESDKEDNGSE-GQLTNREGPELPASKMQRSHSPVPAAAPAHSPSPASPRSVPGSSSQHSASPLVQ 1039
            ||:||||||: ||||.|||.||||||.||:.||.|....:.|||||||||:||||||||.|.|.|
Mouse   976 ESEKEDNGSDNGQLTEREGTELPASKAQRNRSPAPTVTRSSSPSPASPRSIPGSSSQHSTSQLTQ 1040

Human  1040 SPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSPAPL 1104
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.
Mouse  1041 SPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSSAPP 1105

Human  1105 PPSSKDSGVASRESLLQPEVRTPPVGMSPQVLKKSMSAGSEGFPETPVDDEQQAATPSESKKEIL 1169
            |..|||||:.|.||||||:|||||||||||||||||||||||||.|.||.|.|...|::||||||
Mouse  1106 PSLSKDSGMVSSESLLQPDVRTPPVGMSPQVLKKSMSAGSEGFPGTLVDGEDQEGPPADSKKEIL 1170

Human  1170 STTMVTVQQPLELNGEDELVFTLVEELTISGVLDSGRPTSIISFNSDCSARALASGSRPVSIISS 1234
            |||||||||||||||||||||||||||||||||||||||||||||||||.:||||||||||||||
Mouse  1171 STTMVTVQQPLELNGEDELVFTLVEELTISGVLDSGRPTSIISFNSDCSVQALASGSRPVSIISS 1235

Human  1235 ISEDLECYSSTAPVSEVSITQFLPLPKMSLDEKAQDAGSRRSSISSWLSEMSAGSEGEQSCHSFI 1299
            ||||||||||.||||||||||||||||:.|||||:||||||||||||||||||||:|||||||||
Mouse  1236 ISEDLECYSSMAPVSEVSITQFLPLPKLGLDEKARDAGSRRSSISSWLSEMSAGSDGEQSCHSFI 1300

Human  1300 AQTCFGHGEAMAEPVASEFVSSLQNTAVVCREKPKASPDNLLILSEMGDDSFNKAAPIKGCKIST 1364
            ||||||||||||||.|||||||:|||||||||||:..|||||||||||::|.|||||||||||||
Mouse  1301 AQTCFGHGEAMAEPPASEFVSSIQNTAVVCREKPEVGPDNLLILSEMGEESGNKAAPIKGCKIST 1365

Human  1365 VSKAMVTISNTANLSSCEGYIPMKTNITVYPCIAMSPRNIQEPEAPTATPKAGPTLAQSRESKEN 1429
            |.||||||||||:||||||||||||||||||||||||||:||||:.|||||..|..:|::||||.
Mouse  1366 VGKAMVTISNTASLSSCEGYIPMKTNITVYPCIAMSPRNVQEPESSTATPKVSPKASQAQESKEP 1430

Human  1430 SAKKEMKFEDPWLKREEEVKKETAHPNEEGMMRCETATGPSNAETRAEQEQDGKPSPGDRLSSSS 1494
            |.::||||||||||||||||:|.|:.:||| ::||........|.::|||.||:||.|:||||||
Mouse  1431 STRREMKFEDPWLKREEEVKRENAYSSEEG-VKCEPLPSSLKTEGKSEQELDGRPSSGNRLSSSS 1494

Human  1495 GEVSASPVTDNFRRVVDGCEMALPGLATQSPVHPNKSVKSSSLPRAFQKASRQEEPDSLSYYCAA 1559
            .|.:|...|||.||||||||||||||..|||:|.|:::||||||||||||.|.||.||. |:|.|
Mouse  1495 SEAAAFQGTDNVRRVVDGCEMALPGLVAQSPLHVNRNLKSSSLPRAFQKADRHEELDSF-YHCLA 1558

Human  1560 ETNGVGAASGTPPSKATLEGKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHSASGSGTS 1624
            ::||..||||.|.||.|||.|||||||||||||||||||||||||||||||||||||....|.||
Mouse  1559 DSNGFSAASGIPSSKTTLERKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHGGGSSNTS 1623

Human  1625 SPLNQPAAFPAGLPDEPSGKTKDASSSSKLFSAKLEQLASRSNSLGRATVSHYECLSLERAESLS 1689
            |||||||.|.|..|||.:|||||.|||||||||||||||||||||||.|||||||||||||||||
Mouse  1624 SPLNQPATFLACFPDESNGKTKDVSSSSKLFSAKLEQLASRSNSLGRTTVSHYECLSLERAESLS 1688

Human  1690 SVSSRLHAGKDGTMPRAGRSLGRSAGTSPP------SSGASPKAGQSKISAVSRLLLASPRARGP 1748
            |||||:|||||.||||.|||||||.|.|||      |:||||||.||||||||:||||||::|..
Mouse  1689 SVSSRMHAGKDSTMPRTGRSLGRSTGASPPSCGITQSTGASPKASQSKISAVSKLLLASPKSRSS 1753

Human  1749 -SASTTKTLSFSTKSLPQAVGQGSSSPPGGKHTPWSTQSLSRNRSSGLASKLPLRAVSGRISELL 1812
             |.|||||||||||||||:|||.|:.||.|||..||||||||||.||||||||||||:|||||||
Mouse  1754 LSTSTTKTLSFSTKSLPQSVGQSSNLPPSGKHMSWSTQSLSRNRGSGLASKLPLRAVNGRISELL 1818

Human  1813 QGGAGARGLQLRAGPEAEARGGALAEDEPAAAHLLPSPYSKITPPRRPHRCSSGHGSDNSSVLSG 1877
            ||.||.|..||||  |||.|.||.:||:||||||||||||||||||:||||||||||||||||||
Mouse  1819 QGSAGPRSAQLRA--EAEERSGAPSEDKPAAAHLLPSPYSKITPPRKPHRCSSGHGSDNSSVLSG 1881

Human  1878 ELPPAMGKTALFYHSGGSSGYESVMRDSEATGSASSAQDSTSENSSSVGGRCRSLKTPKKRSNPG 1942
            |||||||||||||||||||||||:||||||||||||||||.|||||||||||||||..|||||.|
Mouse  1882 ELPPAMGKTALFYHSGGSSGYESMMRDSEATGSASSAQDSMSENSSSVGGRCRSLKNQKKRSNSG 1946

Human  1943 SQRRRLIPALSLDTSSPVRKPPNSTGVRWVDGPLRSSPRGLGEPFEIKVYEIDDVERLQRRRGGA 2007
            ||||||||||||||.|||||..:|||||||||||||:.|.|||||||||||||||||||||||..
Mouse  1947 SQRRRLIPALSLDTPSPVRKTASSTGVRWVDGPLRSTQRSLGEPFEIKVYEIDDVERLQRRRGAT 2011

Human  2008 SKEAMCFNAKLKILEHRQQRIAEVRAKYEWLMKELEATKQYLMLDPNKWLSEFDLEQVWELDSLE 2072
            |||.||||||||||||||||||||||||||||||||||||||||||||||.|||||||.:|||||
Mouse  2012 SKEVMCFNAKLKILEHRQQRIAEVRAKYEWLMKELEATKQYLMLDPNKWLREFDLEQVLQLDSLE 2076

Human  2073 YLEALECVTERLESRVNFCKAHLMMITCFDITSRRR 2108
            ||||||.|||||||||||||||||||||||||||||
Mouse  2077 YLEALEGVTERLESRVNFCKAHLMMITCFDITSRRR 2112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF26B	NP_060482.2	KISc	450..798	CDD:276812	335/347 (97%)
		KISc	451..798	CDD:214526	334/346 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..825		19/19 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..917		37/40 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..1166		182/229 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1406..1504		55/97 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1653		99/133 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1685..1799		92/120 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1814..1974		138/159 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124		119/122 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..287		20/23 (87%)
Kif26b	NP_001155137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124		119/122 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..286		19/22 (86%)
		KISc	450..798	CDD:276812	335/347 (97%)
		KISc	451..798	CDD:214526	334/346 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..859		48/53 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..917		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..1165		165/209 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1405..1501		56/96 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1649		63/79 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1734		34/46 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1748..1801		38/52 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1883		56/68 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1899..1971		62/71 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952524
Domainoid	1	1.000	2151	1.000	Domainoid score	I264
eggNOG	1	0.900	-	-		E2759_KOG4280
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18623
Inparanoid	1	1.050	3668	1.000	Inparanoid score	I344
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39328
OrthoDB	1	1.010	-	-		D17064at7742
OrthoFinder	1	1.000	-	-		FOG0002018
OrthoInspector	1	1.000	-	-		oto127422
orthoMCL	1	0.900	-	-		OOG6_107262
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4619
SonicParanoid	1	1.000	-	-		X1937
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300