DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAPBPL and side-V

DIOPT Version :9

Sequence 1:	NP_060479.3	Gene:	TAPBPL / 55080	HGNCID:	30683	Length:	468	Species:	Homo sapiens
Sequence 2:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	85/429 - (19%)
Similarity:	128/429 - (29%)	Gaps:	174/429 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    10 LLCLALSGAAETKPHPAEGQWRAVDVVLDCF-LAKDGAHRGALASSEDRARASLVL--------K 65
            |.||:..|.    |.|....||...::.|.| :..||:.|..|.....:.:..|.:        .
  Fly   185 LTCLSSGGV----PPPRVSWWREHALIDDSFQVLPDGSVRNVLRLKNIQRKDLLTMYTCQASNGH 245

Human    66 QVPVLDDGSLEDFT------DFQG-------GTL---------AQDDPPIIFEASVDLVQ----- 103
            .||.|....:.|..      ..||       ||.         |:..|.||:..:..:|:
  Fly   246 VVPALTKKVILDMNLPPLSLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSS 310

Human   104 --------------IPQAEALLHADCSGKEVTCEIS------RYFLQMTETTVKTAAWFMANMQV 148
                          ||..|.      :.::|.|.||      ...|....|||.|..
  Fly   311 TSSDGNTTISELMLIPVPED------NERQVVCSISLNAGITSQQLHEGHTTVMTTL-------- 361

Human   149 SGGGPSISLVMKTPRVTKNEALWH-PTLNL----PLSPQGTVRTAVEFQVMTQTQSLSFLLGSSA 208
              |.....|.:|..||..   :.| |.:||    ||.|.                  :.|.|:..
  Fly   362 --GNGHTGLYLKDSRVLN---VTHAPIVNLNLGAPLDPD------------------NLLKGTDV 403

Human   209 SLDCGFSMAPGLDLISVEW----RLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLT 269
            .|:|.....|.  :..|||    :..|..||.::.:.|                         |.
  Fly   404 YLECDVKANPA--ITRVEWYHSDKQLHSSRGIIISNQT-------------------------LV 441

Human   270 LPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVT 334
            |.|::....|.|.|:.:            |:|.|..     :||..|     |:.  ||
  Fly   442 LQGISKSSHGQYFCRAS------------NLQGSVS-----SNEVYL-----DVK--YP------ 476

Human   335 WTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEP 373
                       .|..:..:.:|.::..|.:|:..:.|.|
  Fly   477 -----------PVCKSESTIIRAALKQTINITCEVDANP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAPBPL	NP_060479.3	IG_like	198..300	CDD:214653	18/105 (17%)
		Ig	204..300	CDD:299845	17/99 (17%)
		IgC_Tapasin_R	266..396	CDD:143248	21/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..468
side-V	NP_611765.2	Ig	42..153	CDD:299845
		IG_like	42..152	CDD:214653
		IGc2	179..245	CDD:197706	15/63 (24%)
		IG_like	179..245	CDD:214653	15/63 (24%)
		Ig	<282..348	CDD:299845	12/71 (17%)
		IGc2	400..459	CDD:197706	17/97 (18%)
		FN3	719..798	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910