DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAPBPL and DIP-eta

DIOPT Version :9

Sequence 1:	NP_060479.3	Gene:	TAPBPL / 55080	HGNCID:	30683	Length:	468	Species:	Homo sapiens
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	61/302 - (20%)
Similarity:	105/302 - (34%)	Gaps:	66/302 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    25 PAEGQWRAVD-----VVLDCFLAKDGAHRGALASSEDRARASLVLKQVPVLDDG--SLEDFTD-- 80
            |.:..|..||     .:.:..:.|:  .|..:|:||.:. .::.:|.:...|.|  ..:..||
  Fly    71 PYKVAWLRVDTQTILTIQNHVITKN--QRIGIANSEHKT-WTMRIKDIKESDKGWYMCQINTDPM 132

Human    81 -FQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMA 144
             .|.|.|....||       |::..|.:..::..:.|...:.|       ..|.:...|..|
  Fly   133 KSQMGYLDVVVPP-------DILDYPTSTDMVVREGSNVTLKC-------AATGSPEPTITW--- 180

Human   145 NMQVSG------GGPSISLVMKTPRVTKNEALWHPTLNLPLSPQGT-------VRTAVEF--QVM 194
             .:.||      .|..:..:..|..|..|....|....|.::..|.       :...|.|  .:.
  Fly   181 -RRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMIT 244

Human   195 TQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGA--TLEP 257
            .|.|.:..:.|...:|||.....|                 :.:..||..:|:.|..|.  :...
  Fly   245 VQNQLIGAVEGKGVTLDCESEAYP-----------------KSINYWTRERGEIVPPGGKYSANV 292

Human   258 AQLGMARDA-SLTLPGLTIQDEGTYICQITTSLYRAQQIIQL 298
            .::|..|:: .|.:..||..:.|:|.|....||......|:|
  Fly   293 TEIGGYRNSMRLHINPLTQAEFGSYRCVAKNSLGDTDGTIKL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAPBPL	NP_060479.3	IG_like	198..300	CDD:214653	23/104 (22%)
		Ig	204..300	CDD:299845	22/98 (22%)
		IgC_Tapasin_R	266..396	CDD:143248	10/34 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..468
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	17/72 (24%)
		IG_like	51..137	CDD:214653	15/68 (22%)
		IG_like	153..237	CDD:214653	14/94 (15%)
		Ig	161..224	CDD:299845	13/73 (18%)
		IG_like	252..335	CDD:214653	22/100 (22%)
		Ig	258..333	CDD:143165	19/91 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910