DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TAPBPL and side-II

DIOPT Version :9

Sequence 1:	NP_060479.3	Gene:	TAPBPL / 55080	HGNCID:	30683	Length:	468	Species:	Homo sapiens
Sequence 2:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	83/410 - (20%)
Similarity:	122/410 - (29%)	Gaps:	161/410 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    83 GGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVT--CEISRYFLQMTE--TTVKTAAWFM 143
            ||..::|..  :....:|.|:             ||.|:  |.|       ||  ..|....||.
  Fly    43 GGISSKDSH--VKTKDIDAVE-------------GKSVSLPCPI-------TEPLDNVYMVLWFR 85

Human   144 ANMQVSGGGPSISLVMK------------TPRVTKNEALWH-----PTLNLPLSPQGTVRTAVEF 191
            .|    .|.|..|..::            .|.|..:.|.:|     .||.:....||..|..|:|
  Fly    86 DN----AGIPLYSFDVRDKESREQPRHWSAPEVFGSRAKFHFDSQPATLEIKRHDQGIYRCRVDF 146

Human   192 QVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLE 256
            :. :||||..|.|        ...:.|...:|...|     || ||             .|..|.
  Fly   147 RT-SQTQSFRFNL--------SVIILPEQPIIMDRW-----GR-QL-------------NGTQLG 183

Human   257 PAQLGMARDASLT---------------LPGLTIQDE------------------------GTYI 282
            |.|.|  .|..:|               :.||.:.::                        ..:.
  Fly   184 PKQEG--DDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEHNSGDVIENRLLWPSVQRNDLNSVFT 246

Human   283 CQITTSLYRAQQIIQLNIQA-SPKVRLSLANEALLPTLI------------------CDIAGYYP 328
            ||            .||.|. .||.:..:.:..|.|.::                  |:.:|..|
  Fly   247 CQ------------ALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRP 299

Human   329 LDVVVTW--TREELGGSPAQVSGASFSSLRQSVAGTYSISSSLT--AEPGSAGATYTCQVTHISL 389
             :.::||  .:.:|..:...:|..|..|....|..|.....|:|  ||..:....|.
  Fly   300 -NAIITWYKGKRQLRRTKDDISKNSTRSELSFVPTTDDDGKSITCRAENPNVNGLYL-------- 355

Human   390 EEPLGASTQVVPPERRTALG 409
             |.:.....|.||.....||
  Fly   356 -ETMWKLNVVYPPLVTLRLG 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TAPBPL	NP_060479.3	IG_like	198..300	CDD:214653	23/140 (16%)
		Ig	204..300	CDD:299845	20/134 (15%)
		IgC_Tapasin_R	266..396	CDD:143248	29/191 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..468
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	33/137 (24%)
		Ig	57..160	CDD:299845	33/135 (24%)
		Ig	188..251	CDD:299845	7/76 (9%)
		Ig	289..363	CDD:299845	17/83 (20%)
		IG_like	289..351	CDD:214653	15/62 (24%)
		Ig_2	376..460	CDD:290606
		IG_like	383..454	CDD:214653
		Ig	470..548	CDD:299845
		IG_like	481..557	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910