Protein Alignment PPP1R3C and Gbs-70E

DIOPT Version :10

• Sequence 1: NP_005389.1
• Gene: PPP1R3C / 5507
• HGNCID: 9293
• Length: 317
• Species: Homo sapiens
• Sequence 2: NP_648708.2
• Gene: Gbs-70E / 39588
• FlyBaseID: FBgn0036428
• Length: 384
• Species: Drosophila melanogaster
• Alignment Length: 241
• Identity: 92/241 - (38%)
• Similarity: 126/241 - (52%)
• Gaps: 54/241 - (22%)

Human    59 KSCLNIK---HKAKSQNDWK---------------------CSHNQ---------AKKRVVFADS 90
            ||||:.|   |  ||||...                     ||.:.         .||.|:|||.
  Fly   103 KSCLSRKSCLH--KSQNTTASSADLSPTDTDVADSASHSCICSKDSDSNGEVSRGPKKHVIFADD 165

Human    91 KGLSLTAIHVFSDLPEE--PAWDLQFDLLDLNDISSAL-KHHEEKNLILDFPQPSTDYLSFRSHF 152
            :|||||.:.|.|: |..  |.|.::|    |..|:..| ..|......:||.||::||||||...
  Fly   166 EGLSLTEVRVMSE-PSNVPPYWSMKF----LEQITQGLVSPHPPDQWTVDFKQPASDYLSFRQKI 225

Human   153 QKNFVCLENCSL--QERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDS-- 213
            :::||.|||..:  :|..|.||:||||:.|:|::.:|:|:|.||:..|:.|.|.: .||....
  Fly   226 ERDFVSLENVIVKDEESIVVGTIKVKNIDFQKEIIVRVTWDDWKSQQDIFCTYAR-AYGPATCAH 289

Human   214 ---DTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRI 256
               |||||.|.||   |:.:::||||.|..|...:||||||:||.|
  Fly   290 VVFDTFSFKITLP---PSSKRLEFCICYRTNETEYWDNNDGKNYTI 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP1R3C	NP_005389.1	PBD_PPP1R3C	51..128	CDD:439280	32/104 (31%)
		PP1-binding motif	84..87		1/2 (50%)
		Interaction with EPM2A. /evidence=ECO:0000269|PubMed:14532330	141..263		56/123 (46%)
		CBM_21	151..256	CDD:427265	48/111 (43%)
Gbs-70E	NP_648708.2	PBD_PPP1R3	<136..198	CDD:455118	21/66 (32%)
		CBM_21	224..332	CDD:427265	48/111 (43%)