DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATG16L1 and UTP15

DIOPT Version :9

Sequence 1:NP_001350671.1 Gene:ATG16L1 / 55054 HGNCID:21498 Length:624 Species:Homo sapiens
Sequence 2:NP_013811.1 Gene:UTP15 / 855118 SGDID:S000004699 Length:513 Species:Saccharomyces cerevisiae


Alignment Length:388 Identity:90/388 - (23%)
Similarity:158/388 - (40%) Gaps:79/388 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   286 SESPLLGHHSSSDAAR-RRSVSSFPVPQDNVDTH----PGSGKEVRV-PATALCVFDAHDGE--- 341
            |::|||...::.:... |:..|:..|.:.|..||    |....:..| .:|.:.:|.:...:   
Yeast    11 SKAPLLPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIK 75

Human   342 --------VNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYL 398
                    |.:..|....:||..|.....|.:::.:..:.... |::.|.......:|.:..:.:
Yeast    76 TFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILL-SINASTHPTHVTKFHTQDNKI 139

Human   399 LA-ASNDFASRIWTVDD-YRLRHTLTGHSGKVLSAKFLLDNARIV-SGSHDRTLKLWDLRSKVC- 459
            || ||:|..:|:|.:.: |..:..|||.:..|.:..|:.....:| :||:|..::|:|.||... 
Yeast   140 LATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGST 204

Human   460 ----------IKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGK-ITALDL 513
                      ::.|.|.|....:.|      .|:   ..:.||:.|...:.|.....| :|.||.
Yeast   205 PIYSLNHDQPVENVIAVSPTQIVSC------GGN---NFKVWDLTSNKKLYERGNFNKAVTCLDY 260

Human   514 -----NPERTELLSCSRDDLLKVIDLRTN-AIK--QTFSAPGFKCGSDWTRVVFSPD----GSYV 566
                 :|.::.|::.|.|..:||.|...| .:|  ..||.|...|       ..||.    ..::
Yeast   261 VENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSC-------AVSPSTAQGNRHL 318

Human   567 AAGSAEGSLYIWSVLTGKVEKVLSKQHS--SSINAVAWSPS------GS-------HVVSVDK 614
            .||.:.|.|   ::.|.|.||..|.:.:  :|.|..|.|.:      ||       |::..||
Yeast   319 VAGLSSGLL---AIRTKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEHIIHNDK 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATG16L1NP_001350671.1 ATG16 31..206 CDD:312208
WD40 <272..390 CDD:225201 22/120 (18%)
WD40 332..622 CDD:238121 77/336 (23%)
WD40 repeat 344..381 CDD:293791 6/36 (17%)
WD40 repeat 387..423 CDD:293791 10/37 (27%)
WD40 repeat 428..465 CDD:293791 11/48 (23%)
WD40 repeat 473..503 CDD:293791 6/29 (21%)
WD40 repeat 508..544 CDD:293791 12/43 (28%)
WD40 repeat 554..590 CDD:293791 10/39 (26%)
WD40 repeat 597..621 CDD:293791 8/31 (26%)
UTP15NP_013811.1 WD40 36..311 CDD:421866 66/291 (23%)
WD40 repeat 43..79 CDD:293791 6/35 (17%)
WD40 repeat 84..122 CDD:293791 7/38 (18%)
WD40 repeat 128..166 CDD:293791 10/37 (27%)
WD40 repeat 171..208 CDD:293791 10/36 (28%)
WD40 repeat 216..248 CDD:293791 8/40 (20%)
WD40 repeat 255..294 CDD:293791 11/38 (29%)
UTP15_C 365..511 CDD:401366 3/14 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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