DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATG16L1 and CAF4

DIOPT Version :9

Sequence 1:	NP_001350671.1	Gene:	ATG16L1 / 55054	HGNCID:	21498	Length:	624	Species:	Homo sapiens
Sequence 2:	NP_012962.3	Gene:	CAF4 / 853908	SGDID:	S000001744	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	664	Identity:	139/664 - (20%)
Similarity:	243/664 - (36%)	Gaps:	203/664 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    34 EIILQYNKLLEKSDLHSVLAQKLQAEKHDV-------------------PNRHEISPGHDG--TW 77
            ||||  |||     .|::|||: |.:|:..                   .:..:...|..|  ::
Yeast    18 EIIL--NKL-----PHAILAQQ-QFQKYITSPIYRYLSKLLLFREVAWPESTKDTQKGQVGIFSF 74

Human    78 NDNQLQEMAQLRI-----------------KHQEELTELHKKRGELAQ--LVIDLNNQMQRKDRE 123
            .:|........||                 |:...|.|..|....:.|  |::|..:.....|:|
Yeast    75 QNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQRLLLDNVDGATNSDKE 139

Human   124 --MQMNEAKIAECLQTISDLETECL--DLRTKLCDLERANQTLK-DEYDALQITFTALEGKLRKT 183
              :|:.:.......:|.|.::...|  |:.|.:.:|. .|:||: ||...|......||.:..|.
Yeast   140 KYVQLPDINTGFVNKTYSRIDLTHLLEDVETNVENLS-INKTLEMDELTRLDSMINELESRKLKI 203

Human   184 TEENQELVTRWMAEKAQEANRLNAENE----KD----------SRRRQARLQKELAEAAKEPLPV 234
            .|..:.:          ::...|.||:    ||          ...|:..|:|::.|
Yeast   204 LERVKHI----------DSKSTNLENDVTLIKDRINFIEEYNLEADREQSLRKQMEE-------- 250

Human   235 EQDDDIEVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLDSITNIFGLSESPLLGHHSSSDA 299
                      :.:|:.:..|....|||            .|.|..:....|.:...:.|..|.|.
Yeast   251 ----------ERSSEASSFTQNEEAIS------------SLCDVESKDTRLKDFYKMPHEKSHDK 293

Human   300 ARR-------RSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQF-SPGSRLLAT 356
            .|:       |:.::|               .:.:|      ...|...:.|:.| :|...|.::
Yeast   294 NRQIISETYSRNTTAF---------------RMTIP------HGEHGNSITALDFDTPWGTLCSS 337

Human   357 GGMDRRVKLWEV-FGEKCEFKGSLSGSNAGITSIEFDSAG-SYLLAASNDFASRIWT-------- 411
            ...||.||:|:: .|.:.   |.|.|..|.:..::.|... :.|:..|.|...::|.
Yeast   338 SYQDRIVKVWDLNHGIQV---GELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSREIY 399

Human   412 VDDYRLR-----------HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-- 463
            :|...|:           |....|..::.:..|  |:..:||||.|:.:..|||.:..||:.:
Yeast   400 LDHSPLKEKTEEIVTPCIHNFELHKDEITALSF--DSEALVSGSRDKKIFHWDLTTGKCIQQLDL 462

Human   464 ----------FAGSSCNDIVC---TE-------QC----VMSGHFDKKIRFWDIRSESIVREMEL 504
                      ....|.|:..|   ||       ||    :.:|..|..:|.||:|....||.:|
Yeast   463 IFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDLRVGKPVRLLE- 526

Human   505 LGK---ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYV 566
             |.   ||:|..:.|:  |::.|.|:.:::.||||::|....:........|:       ||..:
Yeast   527 -GHTDGITSLKFDSEK--LVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDF-------DGKLI 581

Human   567 AAGSAEGSLYIWSV 580
            ..|:.||.:.::::
Yeast   582 TVGANEGGVNVFNM 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L1	NP_001350671.1	ATG16	31..206	CDD:312208	44/216 (20%)
		WD40	<272..390	CDD:225201	25/126 (20%)
		WD40	332..622	CDD:238121	71/300 (24%)
		WD40 repeat	344..381	CDD:293791	12/38 (32%)
		WD40 repeat	387..423	CDD:293791	8/55 (15%)
		WD40 repeat	428..465	CDD:293791	12/48 (25%)
		WD40 repeat	473..503	CDD:293791	13/43 (30%)
		WD40 repeat	508..544	CDD:293791	12/35 (34%)
		WD40 repeat	554..590	CDD:293791	5/27 (19%)
		WD40 repeat	597..621	CDD:293791
CAF4	NP_012962.3	Caf4	65..124	CDD:402971	10/58 (17%)
		WD40	318..641	CDD:238121	71/294 (24%)
		WD40 repeat	322..360	CDD:293791	12/40 (30%)
		WD40 repeat	366..422	CDD:293791	8/55 (15%)
		WD40 repeat	427..461	CDD:293791	12/35 (34%)
		WD40 repeat	472..526	CDD:293791	15/53 (28%)
		WD40 repeat	532..563	CDD:293791	12/32 (38%)
		WD40 repeat	571..611	CDD:293791	6/32 (19%)
		WD40 repeat	617..641	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000