Protein Alignment ATG16L1 and Atg16

DIOPT Version :10

• Sequence 1: NP_001350671.1
• Gene: ATG16L1 / 55054
• HGNCID: 21498
• Length: 624
• Species: Homo sapiens
• Sequence 2: NP_001138124.2
• Gene: Atg16 / 326115
• FlyBaseID: FBgn0039705
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 240/636 - (37%)
• Similarity: 381/636 - (59%)
• Gaps: 57/636 - (8%)

Human    13 WKRHISEQLRRRDRLQRQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTW 77
            |:.|:..:||.|:|.:...|:|||.|.|:|::  .:..:.|..|:....:...|:.:|.|  ||.
  Fly     8 WRAHVVRRLRERNRKECDNFKEIIEQNNRLID--HVAQLKADNLKISVENEQLRNAVSTG--GTG 68

Human    78 NDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLE 142
            ::..:..:.:..:..|||||||||::||.:|:::|||.:::::...:...|..:.|.....:.|.
  Fly    69 SNVAIATLEKKLLSQQEELTELHKRKGENSQMIVDLNQKVEQQRIIISEKEHSLVEQQTNNNRLR 133

Human   143 TECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMAEKAQEANRLNA 207
            .|...|.:.|.:|::.|.|:.||:.|||:.|::||.|||...:||:.|:.|.|..|:::|::||.
  Fly   134 AEVQLLHSSLEELKKLNNTMLDEHTALQLAFSSLEEKLRGVQDENRRLLERLMQYKSKDADKLNE 198

Human   208 ENE--------KDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAISRAA 264
            |||        ...|:|.|:|:::|.:|.:||               :|.....:||    ..|:
  Fly   199 ENESIIRKRLPSIFRKRSAKLKRDLEDAVREP---------------SSSSNAASSP----GAAS 244

Human   265 TKRLSQPA---GGL----------LDSITNIFGLSESPLLGHHSSSDAARRRSVSSFPVPQDNVD 316
            .:|.|.||   |||          ::......||.::..:....::......|.:|       :|
  Fly   245 LQRNSSPAQFVGGLIGDEDFDEAAINGAMEAIGLDDNEYISARFTAGEIAENSRAS-------ID 302

Human   317 THPGSGKEVRV-PATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLS 380
            |...:|...:. |...|..|:||:.|.:||::||..|::||||.||:||||::.....|.:..||
  Fly   303 TLKATGYLGQANPTKILMKFEAHENESHAVRWSPVERMVATGGADRKVKLWDIGKNSTEPRAVLS 367

Human   381 GSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSH 445
            ||:|||.|::|||.|:|:|..|||:.:|:|||.|.|||||||||||||::||::.:..::|:|||
  Fly   368 GSSAGINSVDFDSTGAYILGTSNDYGARVWTVMDNRLRHTLTGHSGKVMAAKYVQEPIKVVTGSH 432

Human   446 DRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE---QCVMSGHFDKKIRFWDIRSESIVREMELLGK 507
            |||||:|||||..||:|.||||||||:|.|:   ..::|||:||||||||||:|....::.:..|
  Fly   433 DRTLKIWDLRSIACIETKFAGSSCNDLVTTDSLGSTIISGHYDKKIRFWDIRTEKQADDVLMPAK 497

Human   508 ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAE 572
            ||:|||:.:...|:...|||.:|::|||.|.:..||:...||...|:.|..|:..|..:|.|||:
  Fly   498 ITSLDLSKDCNYLICSVRDDTIKLLDLRKNQVISTFTNEHFKISCDFARASFNSSGLKIACGSAD 562

Human   573 GSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLWAQ 623
            |::|||:| .|.:|..| |.||:::|||:|||:.:.:.||.|..:..::::
  Fly   563 GAIYIWNV-NGFLEATL-KGHSTAVNAVSWSPNNNMLASVGKNKRCTIYSE 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L1	NP_001350671.1	ATG16	31..206	CDD:462536	56/174 (32%)
		WD40	217..621	CDD:441893	171/420 (41%)
		WD40 repeat	344..381	CDD:293791	17/36 (47%)
		WD40 repeat	387..423	CDD:293791	21/35 (60%)
		WD40 repeat	428..465	CDD:293791	20/36 (56%)
		WD40 repeat	473..503	CDD:293791	16/32 (50%)
		WD40 repeat	508..544	CDD:293791	15/35 (43%)
		WD40 repeat	554..590	CDD:293791	14/35 (40%)
		WD40 repeat	597..621	CDD:293791	9/23 (39%)
Atg16	NP_001138124.2	ATG16	27..197	CDD:462536	56/173 (32%)
		WD40	<310..605	CDD:441893	147/296 (50%)
		WD40 repeat	331..368	CDD:293791	17/36 (47%)
		WD40 repeat	374..410	CDD:293791	21/35 (60%)
		WD40 repeat	415..453	CDD:293791	21/37 (57%)
		WD40 repeat	461..491	CDD:293791	15/29 (52%)
		WD40 repeat	498..536	CDD:293791	16/37 (43%)
		WD40 repeat	544..579	CDD:293791	15/36 (42%)
		WD40 repeat	585..609	CDD:293791	9/23 (39%)