DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATG16L1 and atg-16.1

DIOPT Version :9

Sequence 1:	NP_001350671.1	Gene:	ATG16L1 / 55054	HGNCID:	21498	Length:	624	Species:	Homo sapiens
Sequence 2:	NP_508768.2	Gene:	atg-16.1 / 180717	WormBaseID:	WBGene00017178	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	609	Identity:	178/609 - (29%)
Similarity:	292/609 - (47%)	Gaps:	105/609 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    25 DRLQ--RQAFEEIILQYNKLLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHDGTWNDNQLQ-EMA 86
            :||:  :|..::....||.       :|.||::|: :||..           ||.:.|..| |..
Worm    11 ERLEDVKQRNKQTATLYNN-------YSKLAEQLE-KKHKY-----------GTSSSNSSQLETG 56

Human    87 QL-RIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLETECLDLRT 150
            :| |:|  ||:.||::.:.:..|.:||.|:::...:::   :.|.|||.:...:..::.|.....
Worm    57 ELARVK--EEMAELYRSKCQNDQRLIDANHRIADFEKK---SSAIIAEKIALEATAKSICAKYAK 116

Human   151 KLCDLERA---NQTLKDEYDALQITFTALEGKLRKTTEENQELVTRWMAEKAQEANRLNAENEKD 212
            ...:|:|.   |..|.||..|...|.|.|..:::....:....:.:......|..:.||||...:
Worm   117 TEVELQRLKVDNDQLNDERIASNTTVTMLTKQIQDIENDRIHFLNKIRELNEQRVDFLNAEVALE 181

Human   213 SRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAISRAATKRLSQPAGGLLD 277
            .:||.:|:|                   ::|.....|.|::.:.:..:.||
Worm   182 EKRRNSRIQ-------------------DMITSAVQDITDKDTKLEEMLRA-------------- 213

Human   278 SITNIFGLSESPLLGHHSSSDAARRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEV 342
                                          .|....|.|...|..    ||:.|..|.:..:|||
Worm   214 ------------------------------MPDTNSNGDLLLGDS----VPSRAEFVLECEEGEV 244

Human   343 NAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFK-GSLSGSNAGITSIEFDSAGSYLLAASNDFA 406
            |.|.:..| ...||||.||.:|:|:|.|.....: |:|:||||..|.|:::....:.:|:|||..
Worm   245 NDVHWLDG-ETFATGGSDRNIKIWKVDGHGGYTRIGTLAGSNAAFTRIDYERDRKHFIASSNDKN 308

Human   407 SRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCND 471
            .|||.:|:.||..||:|||.:|...||...:: .||||.||.:|:||::::.|.:::|..|...|
Worm   309 VRIWNLDNSRLLSTLSGHSDQVTCVKFYQSHS-AVSGSADRVIKIWDIQNQRCSRSLFPASKVLD 372

Human   472 IV----CTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPERTELLSCSRDDLLKVI 532
            :.    .:.....|||||||:||:|.||...||.:::.|:||:||:.....|||..:|||.:.:|
Worm   373 VATNMGASPSLFASGHFDKKLRFYDGRSTDPVRTVDMGGRITSLDVTMSGCELLVSTRDDTISLI 437

Human   533 DLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSI 597
            ||||......:||..::..||.:|||.|....||||||:.||:::|:..:.|:||.|.....::|
Worm   438 DLRTFQTVHCYSAENYRTSSDLSRVVLSSGNEYVAAGSSNGSIFVWNRNSTKLEKQLCSNSENAI 502

Human   598 NAVAWSPSGSHVVSVDKGCKAVLW 621
            .:::|:|:|..::|..|.....||
Worm   503 FSLSWNPTGYGLLSSSKQKFVTLW 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATG16L1	NP_001350671.1	ATG16	31..206	CDD:312208	40/179 (22%)
		WD40	<272..390	CDD:225201	31/118 (26%)
		WD40	332..622	CDD:238121	115/295 (39%)
		WD40 repeat	344..381	CDD:293791	14/37 (38%)
		WD40 repeat	387..423	CDD:293791	14/35 (40%)
		WD40 repeat	428..465	CDD:293791	13/36 (36%)
		WD40 repeat	473..503	CDD:293791	14/33 (42%)
		WD40 repeat	508..544	CDD:293791	15/35 (43%)
		WD40 repeat	554..590	CDD:293791	16/35 (46%)
		WD40 repeat	597..621	CDD:293791	6/23 (26%)
atg-16.1	NP_508768.2	ATG16	26..155	CDD:400781	39/152 (26%)
		CwlO1	126..>220	CDD:226400	23/156 (15%)
		WD40	235..527	CDD:238121	115/294 (39%)
		WD40 repeat	246..283	CDD:293791	14/37 (38%)
		WD40 repeat	289..325	CDD:293791	14/35 (40%)
		WD40 repeat	330..365	CDD:293791	13/35 (37%)
		WD40 repeat	371..408	CDD:293791	15/36 (42%)
		WD40 repeat	413..449	CDD:293791	15/35 (43%)
		WD40 repeat	459..495	CDD:293791	16/35 (46%)
		WD40 repeat	502..526	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451902
Domainoid	1	1.000	76	1.000	Domainoid score	I6305
eggNOG	1	0.900	-	-		E1_KOG0288
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I2421
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53779
OrthoDB	1	1.010	-	-		D265783at33208
OrthoFinder	1	1.000	-	-		FOG0004186
OrthoInspector	1	1.000	-	-		mtm4996
orthoMCL	1	0.900	-	-		OOG6_103883
Panther	1	1.100	-	-	O	PTHR19878
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2377
SonicParanoid	1	1.000	-	-		X1444
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800